The Association of MiR-146a and MiR-27a Gene Variants with Type 2 Diabetes: A Meta-Analysis
Background & aim: Several studies have examined the link between existing polymorphisms in the coding miR-146a and miR-27a genes with type 2 diabetes, although the results presented were inconsistent. Accordingly, in the present meta-analysis study, in order to obtain a more accurate estimate, t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | fas |
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Yasuj University Of Medical Sciences
2020-04-01
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| Series: | Armaghane Danesh Bimonthly Journal |
| Subjects: | |
| Online Access: | http://armaghanj.yums.ac.ir/article-1-2557-en.html |
| _version_ | 1818024214180921344 |
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| author | A Karimpour AM Mazare SH Hadianpour M Molla Agha Zarandi M Hosseini B Alipoor |
| author_facet | A Karimpour AM Mazare SH Hadianpour M Molla Agha Zarandi M Hosseini B Alipoor |
| author_sort | A Karimpour |
| collection | DOAJ |
| description | Background & aim: Several studies have examined the link between existing polymorphisms in the coding miR-146a and miR-27a genes with type 2 diabetes, although the results presented were inconsistent. Accordingly, in the present meta-analysis study, in order to obtain a more accurate estimate, the relationship between MiR146a-rs290164 G> C and miR-27a rs8955819 T> C with T2D was investigated.
Methods: To conduct this review study, studies were selected by searching the electronic databases of PubMed, Google Scholar, Scopus, and Science direct until June 6, 2017. A total of 2,069 diabetics and 1,907 healthy subjects entered the meta-analysis to assess the association of rs2910164 and 1090 diabetics and 966 controls to assess the association of rs895819 with type 2 diabetes with an OR chance ratio of 95% confidence interval.
Results: In the present study, the relationship between polymorphism miR-146a rs2910164 and T2D in five different genetic models including allelic, defeated, dominant, over-dominant and co-dominant models was investigated. No significant relationship was observed between miR-146a rs2910164 and miR-27a rs895819 variants with T2D (P> 0.05). There was also no evidence of diffusion bias in the various genetic models studied was observed (P Egger, s test> 0.05).
Conclusion: The present meta-analysis indicated that there was no significant relationship between the variants studied with T2D. To confirm these results, more research is needed in populations with higher sample size and greater geographical diversity. |
| first_indexed | 2024-12-10T03:56:39Z |
| format | Article |
| id | doaj.art-36460fda296c4de5bb0b630c8a6cd06b |
| institution | Directory Open Access Journal |
| issn | 1728-6514 1728-6514 |
| language | fas |
| last_indexed | 2024-12-10T03:56:39Z |
| publishDate | 2020-04-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-36460fda296c4de5bb0b630c8a6cd06b2022-12-22T02:03:06ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65141728-65142020-04-01252225239The Association of MiR-146a and MiR-27a Gene Variants with Type 2 Diabetes: A Meta-AnalysisA Karimpour0AM Mazare1SH Hadianpour2M Molla Agha Zarandi3M Hosseini4B Alipoor5 Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran Ministry of Health and Medical, Tehran, Iran Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran Department of Laboratory Sciences, Yasuj University of Medical Sciences, Yasuj, Iran. Background & aim: Several studies have examined the link between existing polymorphisms in the coding miR-146a and miR-27a genes with type 2 diabetes, although the results presented were inconsistent. Accordingly, in the present meta-analysis study, in order to obtain a more accurate estimate, the relationship between MiR146a-rs290164 G> C and miR-27a rs8955819 T> C with T2D was investigated. Methods: To conduct this review study, studies were selected by searching the electronic databases of PubMed, Google Scholar, Scopus, and Science direct until June 6, 2017. A total of 2,069 diabetics and 1,907 healthy subjects entered the meta-analysis to assess the association of rs2910164 and 1090 diabetics and 966 controls to assess the association of rs895819 with type 2 diabetes with an OR chance ratio of 95% confidence interval. Results: In the present study, the relationship between polymorphism miR-146a rs2910164 and T2D in five different genetic models including allelic, defeated, dominant, over-dominant and co-dominant models was investigated. No significant relationship was observed between miR-146a rs2910164 and miR-27a rs895819 variants with T2D (P> 0.05). There was also no evidence of diffusion bias in the various genetic models studied was observed (P Egger, s test> 0.05). Conclusion: The present meta-analysis indicated that there was no significant relationship between the variants studied with T2D. To confirm these results, more research is needed in populations with higher sample size and greater geographical diversity.http://armaghanj.yums.ac.ir/article-1-2557-en.htmlrs2910164rs895819type 2 diabetesmeta-analysis |
| spellingShingle | A Karimpour AM Mazare SH Hadianpour M Molla Agha Zarandi M Hosseini B Alipoor The Association of MiR-146a and MiR-27a Gene Variants with Type 2 Diabetes: A Meta-Analysis Armaghane Danesh Bimonthly Journal rs2910164 rs895819 type 2 diabetes meta-analysis |
| title | The Association of MiR-146a and MiR-27a Gene Variants with Type 2 Diabetes: A Meta-Analysis |
| title_full | The Association of MiR-146a and MiR-27a Gene Variants with Type 2 Diabetes: A Meta-Analysis |
| title_fullStr | The Association of MiR-146a and MiR-27a Gene Variants with Type 2 Diabetes: A Meta-Analysis |
| title_full_unstemmed | The Association of MiR-146a and MiR-27a Gene Variants with Type 2 Diabetes: A Meta-Analysis |
| title_short | The Association of MiR-146a and MiR-27a Gene Variants with Type 2 Diabetes: A Meta-Analysis |
| title_sort | association of mir 146a and mir 27a gene variants with type 2 diabetes a meta analysis |
| topic | rs2910164 rs895819 type 2 diabetes meta-analysis |
| url | http://armaghanj.yums.ac.ir/article-1-2557-en.html |
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