Diagnostic performance of serum steatosis biomarkers in Prediction of Non Alcoholic Fatty Liver Disease in Adult Asymptomatic Egyptians
Background: Non alcoholic fatty liver disease (NAFLD) is the most common liver disease involving about 25% of the world’s population. Liver biopsy is the current gold standard for the diagnosis and assessment of the severity of hepatic steatosis. However, because of its invasive nature and the risk...
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| Format: | Article |
| Language: | English |
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South Valley University, Faculty of Medicine
2022-07-01
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| Series: | SVU - International Journal of Medical Sciences |
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| Online Access: | https://svuijm.journals.ekb.eg/article_222747.html |
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| author | Mostafa Abd El Hamid Ali* Ghada Moustafa Kamal Moustafa Adel Ahmed Younis Amr Mohammed Zaghloul |
| author_facet | Mostafa Abd El Hamid Ali* Ghada Moustafa Kamal Moustafa Adel Ahmed Younis Amr Mohammed Zaghloul |
| author_sort | Mostafa Abd El Hamid Ali* |
| collection | DOAJ |
| description | Background: Non alcoholic fatty liver disease (NAFLD) is the most common liver disease involving about 25% of the world’s population. Liver biopsy is the current gold standard for the diagnosis and assessment of the severity of hepatic steatosis. However, because of its invasive nature and the risk of complications, many non invasive imaging modalities and laboratory markers were evaluated for the assessment of the hepatic steatosis.
Objectives: To evaluate the diagnostic performance of noninvasive indices to predict NAFLD in Egyptian patients.
Patients and methods: A cross-sectional study was conducted in a series of adult asymptomatic subjects. NAFLD was diagnosed in 100 cases by ultrasonography for whom controlled attenuation parameters (CAP) examination was done. General, anthropometric and biochemical data were collected. Fatty liver indexes (FLI), Zhejiang University index (ZJU) and hepatic steatosis index (HSI) were calculated. Roc curve analysis was used to detect the optimal cutoff of different models that predict steatosis.
Results: The area under the receiver operating characteristic (AUROC) curve of the FLI, ZJU index, and HSI was 0.999, 0.929, and 0.898, respectively. The (AUROC) curve of the FLI and ZJU index were significantly higher than that of HSI (P=0.0001 and P=0.001, respectively). The optimal cut off values for the FLI, ZJU index, and HSIwere 30, 40.3, and 39.6, respectively.
Conclusion: FLI, ZJU and HSI could be accurate and applicable tools for the noninvasive diagnosis of NAFLD in Egyptian patients. |
| first_indexed | 2024-04-13T21:03:27Z |
| format | Article |
| id | doaj.art-364659e996f74c17a79922dd3ae7fb42 |
| institution | Directory Open Access Journal |
| issn | 2735-427X 2636-3402 |
| language | English |
| last_indexed | 2024-04-13T21:03:27Z |
| publishDate | 2022-07-01 |
| publisher | South Valley University, Faculty of Medicine |
| record_format | Article |
| series | SVU - International Journal of Medical Sciences |
| spelling | doaj.art-364659e996f74c17a79922dd3ae7fb422022-12-22T02:30:03ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2735-427X2636-34022022-07-01525163https://dx.doi.org/10.21608/svuijm.2022.122580.1281 Diagnostic performance of serum steatosis biomarkers in Prediction of Non Alcoholic Fatty Liver Disease in Adult Asymptomatic EgyptiansMostafa Abd El Hamid Ali*0Ghada Moustafa Kamal1 Moustafa Adel Ahmed Younis2Amr Mohammed Zaghloul3Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.Department of Clinical Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt.Tropical Medicine and Gastroenterology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.Background: Non alcoholic fatty liver disease (NAFLD) is the most common liver disease involving about 25% of the world’s population. Liver biopsy is the current gold standard for the diagnosis and assessment of the severity of hepatic steatosis. However, because of its invasive nature and the risk of complications, many non invasive imaging modalities and laboratory markers were evaluated for the assessment of the hepatic steatosis. Objectives: To evaluate the diagnostic performance of noninvasive indices to predict NAFLD in Egyptian patients. Patients and methods: A cross-sectional study was conducted in a series of adult asymptomatic subjects. NAFLD was diagnosed in 100 cases by ultrasonography for whom controlled attenuation parameters (CAP) examination was done. General, anthropometric and biochemical data were collected. Fatty liver indexes (FLI), Zhejiang University index (ZJU) and hepatic steatosis index (HSI) were calculated. Roc curve analysis was used to detect the optimal cutoff of different models that predict steatosis. Results: The area under the receiver operating characteristic (AUROC) curve of the FLI, ZJU index, and HSI was 0.999, 0.929, and 0.898, respectively. The (AUROC) curve of the FLI and ZJU index were significantly higher than that of HSI (P=0.0001 and P=0.001, respectively). The optimal cut off values for the FLI, ZJU index, and HSIwere 30, 40.3, and 39.6, respectively. Conclusion: FLI, ZJU and HSI could be accurate and applicable tools for the noninvasive diagnosis of NAFLD in Egyptian patients.https://svuijm.journals.ekb.eg/article_222747.htmlnafld; steatosis indices; non invasive; cap |
| spellingShingle | Mostafa Abd El Hamid Ali* Ghada Moustafa Kamal Moustafa Adel Ahmed Younis Amr Mohammed Zaghloul Diagnostic performance of serum steatosis biomarkers in Prediction of Non Alcoholic Fatty Liver Disease in Adult Asymptomatic Egyptians SVU - International Journal of Medical Sciences nafld; steatosis indices; non invasive; cap |
| title | Diagnostic performance of serum steatosis biomarkers in Prediction of Non Alcoholic Fatty Liver Disease in Adult Asymptomatic Egyptians |
| title_full | Diagnostic performance of serum steatosis biomarkers in Prediction of Non Alcoholic Fatty Liver Disease in Adult Asymptomatic Egyptians |
| title_fullStr | Diagnostic performance of serum steatosis biomarkers in Prediction of Non Alcoholic Fatty Liver Disease in Adult Asymptomatic Egyptians |
| title_full_unstemmed | Diagnostic performance of serum steatosis biomarkers in Prediction of Non Alcoholic Fatty Liver Disease in Adult Asymptomatic Egyptians |
| title_short | Diagnostic performance of serum steatosis biomarkers in Prediction of Non Alcoholic Fatty Liver Disease in Adult Asymptomatic Egyptians |
| title_sort | diagnostic performance of serum steatosis biomarkers in prediction of non alcoholic fatty liver disease in adult asymptomatic egyptians |
| topic | nafld; steatosis indices; non invasive; cap |
| url | https://svuijm.journals.ekb.eg/article_222747.html |
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