Cerebral trypanosomiasis and AIDS
A 36 year-old black female, complaining of headache of one month's duration presented with nausea, vomiting, somnolence, short memory problems, loss of weight, and no fever history. Smoker, intravenous drugs abuser, promiscuous lifestyle. Physical examination: left homonimous hemianopsia, left...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academia Brasileira de Neurologia (ABNEURO)
2002-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000500009 |
| _version_ | 1819156438779428864 |
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| author | Antunes Apio Claudio Martins Cecchini Felipe Martins de Lima Bolli Fernando von Bock Oliveira Patricia Polanczyk de Rebouças Ricardo Gurgel Monte Thais Lampert Fricke Daniele |
| author_facet | Antunes Apio Claudio Martins Cecchini Felipe Martins de Lima Bolli Fernando von Bock Oliveira Patricia Polanczyk de Rebouças Ricardo Gurgel Monte Thais Lampert Fricke Daniele |
| author_sort | Antunes Apio Claudio Martins |
| collection | DOAJ |
| description | A 36 year-old black female, complaining of headache of one month's duration presented with nausea, vomiting, somnolence, short memory problems, loss of weight, and no fever history. Smoker, intravenous drugs abuser, promiscuous lifestyle. Physical examination: left homonimous hemianopsia, left hemiparesis, no papilledema, diffuse hyperreflexia, slowness of movements. Brain CT scan: tumor-like lesion in the splenium of the corpus calosum, measuring 3.5 x 1.4 cm, with heterogeneous enhancing pattern, sugesting a primary CNS tumor. Due to the possibility of CNS infection, a lumbar puncture disclosed an opening pressure of 380 mmH(2)0; 11 white cells (lymphocytes); glucose 18 mg/dl (serum glucose 73 mg/dl); proteins 139 mg/dl; presence of Trypanosoma parasites. Serum Elisa-HIV tests turned out to be positive. Treatment with benznidazole dramatically improved clinical and radiographic picture, but the patient died 6 weeks later because of respiratory failure. T. cruzi infection of the CNS is a rare disease, but we have an increasing number of cases in HIV immunecompromised patients. Diagnosis by direct observation of CSF is uncommon, and most of the cases are diagnosed by pathological examination. It is a highly lethal disease, even when properly diagnosed and treated. This article intends to include cerebral trypanosomiasis in the differential diagnosis of intracranial space-occupying lesions, especially in immunecompromised patients from endemic regions. |
| first_indexed | 2024-12-22T15:52:53Z |
| format | Article |
| id | doaj.art-3647566362aa4740b6a60cf75bba62bb |
| institution | Directory Open Access Journal |
| issn | 0004-282X 1678-4227 |
| language | English |
| last_indexed | 2024-12-22T15:52:53Z |
| publishDate | 2002-01-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-3647566362aa4740b6a60cf75bba62bb2022-12-21T18:20:51ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria0004-282X1678-42272002-01-01603B730733Cerebral trypanosomiasis and AIDSAntunes Apio Claudio MartinsCecchini Felipe Martins de LimaBolli Fernando von BockOliveira Patricia Polanczyk deRebouças Ricardo GurgelMonte Thais LampertFricke DanieleA 36 year-old black female, complaining of headache of one month's duration presented with nausea, vomiting, somnolence, short memory problems, loss of weight, and no fever history. Smoker, intravenous drugs abuser, promiscuous lifestyle. Physical examination: left homonimous hemianopsia, left hemiparesis, no papilledema, diffuse hyperreflexia, slowness of movements. Brain CT scan: tumor-like lesion in the splenium of the corpus calosum, measuring 3.5 x 1.4 cm, with heterogeneous enhancing pattern, sugesting a primary CNS tumor. Due to the possibility of CNS infection, a lumbar puncture disclosed an opening pressure of 380 mmH(2)0; 11 white cells (lymphocytes); glucose 18 mg/dl (serum glucose 73 mg/dl); proteins 139 mg/dl; presence of Trypanosoma parasites. Serum Elisa-HIV tests turned out to be positive. Treatment with benznidazole dramatically improved clinical and radiographic picture, but the patient died 6 weeks later because of respiratory failure. T. cruzi infection of the CNS is a rare disease, but we have an increasing number of cases in HIV immunecompromised patients. Diagnosis by direct observation of CSF is uncommon, and most of the cases are diagnosed by pathological examination. It is a highly lethal disease, even when properly diagnosed and treated. This article intends to include cerebral trypanosomiasis in the differential diagnosis of intracranial space-occupying lesions, especially in immunecompromised patients from endemic regions.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000500009trypanosomiasistrypanosoma cruziAIDSbenznidazolenifurtimox |
| spellingShingle | Antunes Apio Claudio Martins Cecchini Felipe Martins de Lima Bolli Fernando von Bock Oliveira Patricia Polanczyk de Rebouças Ricardo Gurgel Monte Thais Lampert Fricke Daniele Cerebral trypanosomiasis and AIDS Arquivos de Neuro-Psiquiatria trypanosomiasis trypanosoma cruzi AIDS benznidazole nifurtimox |
| title | Cerebral trypanosomiasis and AIDS |
| title_full | Cerebral trypanosomiasis and AIDS |
| title_fullStr | Cerebral trypanosomiasis and AIDS |
| title_full_unstemmed | Cerebral trypanosomiasis and AIDS |
| title_short | Cerebral trypanosomiasis and AIDS |
| title_sort | cerebral trypanosomiasis and aids |
| topic | trypanosomiasis trypanosoma cruzi AIDS benznidazole nifurtimox |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2002000500009 |
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