Lifestyle and subsequent meningioma in childhood cancer survivors: A report from the St. Jude Lifetime Cohort study
Abstract Background Lifestyle is associated with meningioma risk in the general population. Aims We assessed longitudinal associations between lifestyle‐associated factors and subsequent meningiomas in childhood cancer survivors. Methods and results Childhood cancer survivors age ≥18 years in the St...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Cancer Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cnr2.1944 |
| _version_ | 1797344804567252992 |
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| author | Aron Onerup Sedigheh Mirzaei S. Shalini Bhatia Megan E. Ware Lenat Joffe Lucie M. Turcotte Chelsea G. Goodenough Yadav Sapkota Stephanie B. Dixon Matthew D. Wogksch Matthew J. Ehrhardt Gregory T. Armstrong Melissa M. Hudson Kirsten K. Ness |
| author_facet | Aron Onerup Sedigheh Mirzaei S. Shalini Bhatia Megan E. Ware Lenat Joffe Lucie M. Turcotte Chelsea G. Goodenough Yadav Sapkota Stephanie B. Dixon Matthew D. Wogksch Matthew J. Ehrhardt Gregory T. Armstrong Melissa M. Hudson Kirsten K. Ness |
| author_sort | Aron Onerup |
| collection | DOAJ |
| description | Abstract Background Lifestyle is associated with meningioma risk in the general population. Aims We assessed longitudinal associations between lifestyle‐associated factors and subsequent meningiomas in childhood cancer survivors. Methods and results Childhood cancer survivors age ≥18 years in the St. Jude Lifetime Cohort Study were evaluated for body composition, self‐reported physical activity, cardiopulmonary fitness, muscle strength, smoking, and alcohol consumption at baseline. Time to first meningioma analyses were performed, adjusted for sex, age at diagnosis and baseline assessment, treatment decade, and childhood cancer treatment exposures. The study included 4,072 survivors (47% female; [mean (SD)] 9 (6) years at diagnosis; 30 (8.5) years at the start of follow‐up, with 7.0 (3.3) years of follow‐up). 30% of the participants were survivors of acute lymphoblastic leukemia and 29% of the participants had received cranial radiation. During follow‐up, 90 participants developed ≥1 meningioma, of whom 73% were survivors of acute lymphoblastic leukemia, with cranial radiation being the strongest risk factor (relative risk [RR] 29.7, 95% confidence interval [CI] 10.6‐83.2). Muscle strength assessed by knee extension was associated with a lower risk of developing a meningioma in the adjusted analyses (RR 0.5, 95% CI 0.2‐1.0, p = 0.04 for quartiles 3‐4 vs. 1). No other lifestyle‐associated variable was associated with subsequent meningioma. Conclusion Independent of cranial radiation, muscle strength was associated with a lower risk of developing a subsequent meningioma in childhood cancer survivors. |
| first_indexed | 2024-03-08T11:08:14Z |
| format | Article |
| id | doaj.art-3648d9a6d71b4fafa382a1c7dad37e95 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-03-08T11:08:14Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-3648d9a6d71b4fafa382a1c7dad37e952024-01-26T14:25:02ZengWileyCancer Reports2573-83482024-01-0171n/an/a10.1002/cnr2.1944Lifestyle and subsequent meningioma in childhood cancer survivors: A report from the St. Jude Lifetime Cohort studyAron Onerup0Sedigheh Mirzaei S.1Shalini Bhatia2Megan E. Ware3Lenat Joffe4Lucie M. Turcotte5Chelsea G. Goodenough6Yadav Sapkota7Stephanie B. Dixon8Matthew D. Wogksch9Matthew J. Ehrhardt10Gregory T. Armstrong11Melissa M. Hudson12Kirsten K. Ness13Department of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USADepartment of Biostatistics St Jude Children's Research Hospital Memphis Tennessee USADepartment of Biostatistics St Jude Children's Research Hospital Memphis Tennessee USADepartment of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USADepartment of Pediatrics Zucker School of Medicine at Hofstra/Northwell New Hyde Park New York USADepartment of Pediatrics University of Minnesota Minneapolis Minnesota USADepartment of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USADepartment of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USADepartment of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USADepartment of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USADepartment of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USADepartment of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USADepartment of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USADepartment of Epidemiology and Cancer Control St Jude Children's Research Hospital Memphis Tennessee USAAbstract Background Lifestyle is associated with meningioma risk in the general population. Aims We assessed longitudinal associations between lifestyle‐associated factors and subsequent meningiomas in childhood cancer survivors. Methods and results Childhood cancer survivors age ≥18 years in the St. Jude Lifetime Cohort Study were evaluated for body composition, self‐reported physical activity, cardiopulmonary fitness, muscle strength, smoking, and alcohol consumption at baseline. Time to first meningioma analyses were performed, adjusted for sex, age at diagnosis and baseline assessment, treatment decade, and childhood cancer treatment exposures. The study included 4,072 survivors (47% female; [mean (SD)] 9 (6) years at diagnosis; 30 (8.5) years at the start of follow‐up, with 7.0 (3.3) years of follow‐up). 30% of the participants were survivors of acute lymphoblastic leukemia and 29% of the participants had received cranial radiation. During follow‐up, 90 participants developed ≥1 meningioma, of whom 73% were survivors of acute lymphoblastic leukemia, with cranial radiation being the strongest risk factor (relative risk [RR] 29.7, 95% confidence interval [CI] 10.6‐83.2). Muscle strength assessed by knee extension was associated with a lower risk of developing a meningioma in the adjusted analyses (RR 0.5, 95% CI 0.2‐1.0, p = 0.04 for quartiles 3‐4 vs. 1). No other lifestyle‐associated variable was associated with subsequent meningioma. Conclusion Independent of cranial radiation, muscle strength was associated with a lower risk of developing a subsequent meningioma in childhood cancer survivors.https://doi.org/10.1002/cnr2.1944body compositionchildhood cancerepidemiologyfitnessmeningiomasurvivorship |
| spellingShingle | Aron Onerup Sedigheh Mirzaei S. Shalini Bhatia Megan E. Ware Lenat Joffe Lucie M. Turcotte Chelsea G. Goodenough Yadav Sapkota Stephanie B. Dixon Matthew D. Wogksch Matthew J. Ehrhardt Gregory T. Armstrong Melissa M. Hudson Kirsten K. Ness Lifestyle and subsequent meningioma in childhood cancer survivors: A report from the St. Jude Lifetime Cohort study Cancer Reports body composition childhood cancer epidemiology fitness meningioma survivorship |
| title | Lifestyle and subsequent meningioma in childhood cancer survivors: A report from the St. Jude Lifetime Cohort study |
| title_full | Lifestyle and subsequent meningioma in childhood cancer survivors: A report from the St. Jude Lifetime Cohort study |
| title_fullStr | Lifestyle and subsequent meningioma in childhood cancer survivors: A report from the St. Jude Lifetime Cohort study |
| title_full_unstemmed | Lifestyle and subsequent meningioma in childhood cancer survivors: A report from the St. Jude Lifetime Cohort study |
| title_short | Lifestyle and subsequent meningioma in childhood cancer survivors: A report from the St. Jude Lifetime Cohort study |
| title_sort | lifestyle and subsequent meningioma in childhood cancer survivors a report from the st jude lifetime cohort study |
| topic | body composition childhood cancer epidemiology fitness meningioma survivorship |
| url | https://doi.org/10.1002/cnr2.1944 |
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