PTX3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese Japanese men
Background: Obesity, an independent cardiovascular disease risk factor, is the leading cause of death in the world. It has been previously shown that arterial stiffness,which is an index of cardiovascular disease, is significantly higher in Japanese overweight and obese men. Increased levels of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MRE Press
2022-02-01
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| Series: | Journal of Men's Health |
| Subjects: | |
| Online Access: | https://imrpress.com/journal/JOMH/18/2/10.31083/jomh.2021.139 |
| _version_ | 1797326569132261376 |
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| author | Asako Zempo-Miyaki Hiroshi Kumagai Toru Yoshikawa Kiyoji Tanaka Seiji Maeda |
| author_facet | Asako Zempo-Miyaki Hiroshi Kumagai Toru Yoshikawa Kiyoji Tanaka Seiji Maeda |
| author_sort | Asako Zempo-Miyaki |
| collection | DOAJ |
| description | Background: Obesity, an independent cardiovascular disease
risk factor, is the leading cause of death in the world. It has been previously
shown that arterial stiffness,which is an index of cardiovascular disease, is
significantly higher in Japanese overweight and obese men. Increased levels
of pentraxin3 (PTX3), a novel anti-inflammatory substance mainly produced in
the atherosclerotic region, due to weight reduction has been proposed to reflect
an improvement in arterial stiffness. However, this has not been investigated.
Methods: Here, we elucidate whether an individual who has significantly
increased plasma PTX3 concentration result in a significantly decreased arterial
stiffness compared to a smaller change in PTX3 level after a 12-week dietary
modified weight reduction program in twenty overweight or obese Japanese men.
A well-balanced dietary modification weight-loss program was implemented for
overweight and obese men over a course of 12-week.
Results: Prior to and after the program, we measured anthropometric variables,
blood pressure, arterial stiffness, and circulating biochemistry, including
plasma PTX3 concentrations. We then compared the differences in arterial
stiffness between two groups, low or high ΔPTX3 groups, based on the
median of delta of plasma PTX3 levels before and after weight reduction via
modified diet habit in men with overweight and obesity. Carotid-femoral pulse
wave velocity (PWV) as index of central arterial stiifness and brachial-ankle PWV
as index of whole body arterial stiffness were significantly decreased in the
high ΔPTX3 group after dietary modification.
Conclusions: Our present results suggest that PTX3 could be a clinically
useful biochemical index for monitoring appropriate arterial function maintenance
in obese weight control. |
| first_indexed | 2024-03-08T06:26:06Z |
| format | Article |
| id | doaj.art-364dd64dd59c4a38a5709c6cfed38a2b |
| institution | Directory Open Access Journal |
| issn | 1875-6859 |
| language | English |
| last_indexed | 2024-03-08T06:26:06Z |
| publishDate | 2022-02-01 |
| publisher | MRE Press |
| record_format | Article |
| series | Journal of Men's Health |
| spelling | doaj.art-364dd64dd59c4a38a5709c6cfed38a2b2024-02-03T14:44:29ZengMRE PressJournal of Men's Health1875-68592022-02-0118204810.31083/jomh.2021.139S1875-6867(21)00279-7PTX3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese Japanese menAsako Zempo-Miyaki0Hiroshi Kumagai1Toru Yoshikawa2Kiyoji Tanaka3Seiji Maeda4Faculty of Sports & Health Science, Ryutsu Keizai University, 301-8555 Ibaraki, JapanThe Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USAFaculty of Sports & Health Science, Ryutsu Keizai University, 301-8555 Ibaraki, JapanFaculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, 305-8574 Ibaraki, JapanFaculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, 305-8574 Ibaraki, JapanBackground: Obesity, an independent cardiovascular disease risk factor, is the leading cause of death in the world. It has been previously shown that arterial stiffness,which is an index of cardiovascular disease, is significantly higher in Japanese overweight and obese men. Increased levels of pentraxin3 (PTX3), a novel anti-inflammatory substance mainly produced in the atherosclerotic region, due to weight reduction has been proposed to reflect an improvement in arterial stiffness. However, this has not been investigated. Methods: Here, we elucidate whether an individual who has significantly increased plasma PTX3 concentration result in a significantly decreased arterial stiffness compared to a smaller change in PTX3 level after a 12-week dietary modified weight reduction program in twenty overweight or obese Japanese men. A well-balanced dietary modification weight-loss program was implemented for overweight and obese men over a course of 12-week. Results: Prior to and after the program, we measured anthropometric variables, blood pressure, arterial stiffness, and circulating biochemistry, including plasma PTX3 concentrations. We then compared the differences in arterial stiffness between two groups, low or high ΔPTX3 groups, based on the median of delta of plasma PTX3 levels before and after weight reduction via modified diet habit in men with overweight and obesity. Carotid-femoral pulse wave velocity (PWV) as index of central arterial stiifness and brachial-ankle PWV as index of whole body arterial stiffness were significantly decreased in the high ΔPTX3 group after dietary modification. Conclusions: Our present results suggest that PTX3 could be a clinically useful biochemical index for monitoring appropriate arterial function maintenance in obese weight control.https://imrpress.com/journal/JOMH/18/2/10.31083/jomh.2021.139inflammationobesityptx3weight lossmen |
| spellingShingle | Asako Zempo-Miyaki Hiroshi Kumagai Toru Yoshikawa Kiyoji Tanaka Seiji Maeda PTX3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese Japanese men Journal of Men's Health inflammation obesity ptx3 weight loss men |
| title | PTX3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese Japanese men |
| title_full | PTX3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese Japanese men |
| title_fullStr | PTX3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese Japanese men |
| title_full_unstemmed | PTX3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese Japanese men |
| title_short | PTX3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese Japanese men |
| title_sort | ptx3 as a biomarker of lowered arterial stiffness due to weight loss in overweight and obese japanese men |
| topic | inflammation obesity ptx3 weight loss men |
| url | https://imrpress.com/journal/JOMH/18/2/10.31083/jomh.2021.139 |
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