<i>Staphylococcus aureus</i> Toxins: An Update on Their Pathogenic Properties and Potential Treatments
<i>Staphylococcus aureus</i> is a clinically important pathogen that causes a wide range of human infections, from minor skin infections to severe tissue infection and sepsis. <i>S. aureus</i> has a high level of antibiotic resistance and is a common cause of infections in ho...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/13/10/677 |
| _version_ | 1797513050204405760 |
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| author | Nour Ahmad-Mansour Paul Loubet Cassandra Pouget Catherine Dunyach-Remy Albert Sotto Jean-Philippe Lavigne Virginie Molle |
| author_facet | Nour Ahmad-Mansour Paul Loubet Cassandra Pouget Catherine Dunyach-Remy Albert Sotto Jean-Philippe Lavigne Virginie Molle |
| author_sort | Nour Ahmad-Mansour |
| collection | DOAJ |
| description | <i>Staphylococcus aureus</i> is a clinically important pathogen that causes a wide range of human infections, from minor skin infections to severe tissue infection and sepsis. <i>S. aureus</i> has a high level of antibiotic resistance and is a common cause of infections in hospitals and the community. The rising prevalence of community-acquired methicillin-resistant <i>S. aureus</i> (CA-MRSA), combined with the important severity of <i>S. aureus</i> infections in general, has resulted in the frequent use of anti-staphylococcal antibiotics, leading to increasing resistance rates. Antibiotic-resistant <i>S. aureus</i> continues to be a major health concern, necessitating the development of novel therapeutic strategies. <i>S. aureus</i> uses a wide range of virulence factors, such as toxins, to develop an infection in the host. Recently, anti-virulence treatments that directly or indirectly neutralize <i>S. aureus</i> toxins have showed promise. In this review, we provide an update on toxin pathogenic characteristics, as well as anti-toxin therapeutical strategies. |
| first_indexed | 2024-03-10T06:10:15Z |
| format | Article |
| id | doaj.art-364f3fde1efd427e9de98b4f30caecce |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T06:10:15Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-364f3fde1efd427e9de98b4f30caecce2023-11-22T20:12:46ZengMDPI AGToxins2072-66512021-09-01131067710.3390/toxins13100677<i>Staphylococcus aureus</i> Toxins: An Update on Their Pathogenic Properties and Potential TreatmentsNour Ahmad-Mansour0Paul Loubet1Cassandra Pouget2Catherine Dunyach-Remy3Albert Sotto4Jean-Philippe Lavigne5Virginie Molle6Laboratory of Pathogen Host Interactions, CNRS UMR5235, Université de Montpellier, 34000 Montpellier, FranceVirulence Bactérienne et Infections Chroniques, INSERM U1047, Department of Infectious and Tropical Diseases, Université de Montpellier, 30908 Nîmes, FranceVirulence Bactérienne et Infections Chroniques, INSERM U1047, Université de Montpellier, 30908 Nîmes, FranceVirulence Bactérienne et Infections Chroniques, INSERM U1047, Department of Microbiology and Hospital Hygiene, Université de Montpellier, 30908 Nîmes, FranceVirulence Bactérienne et Infections Chroniques, INSERM U1047, Department of Infectious and Tropical Diseases, Université de Montpellier, 30908 Nîmes, FranceVirulence Bactérienne et Infections Chroniques, INSERM U1047, Department of Microbiology and Hospital Hygiene, Université de Montpellier, 30908 Nîmes, FranceLaboratory of Pathogen Host Interactions, CNRS UMR5235, Université de Montpellier, 34000 Montpellier, France<i>Staphylococcus aureus</i> is a clinically important pathogen that causes a wide range of human infections, from minor skin infections to severe tissue infection and sepsis. <i>S. aureus</i> has a high level of antibiotic resistance and is a common cause of infections in hospitals and the community. The rising prevalence of community-acquired methicillin-resistant <i>S. aureus</i> (CA-MRSA), combined with the important severity of <i>S. aureus</i> infections in general, has resulted in the frequent use of anti-staphylococcal antibiotics, leading to increasing resistance rates. Antibiotic-resistant <i>S. aureus</i> continues to be a major health concern, necessitating the development of novel therapeutic strategies. <i>S. aureus</i> uses a wide range of virulence factors, such as toxins, to develop an infection in the host. Recently, anti-virulence treatments that directly or indirectly neutralize <i>S. aureus</i> toxins have showed promise. In this review, we provide an update on toxin pathogenic characteristics, as well as anti-toxin therapeutical strategies.https://www.mdpi.com/2072-6651/13/10/677<i>Staphylococcus aureus</i>pathogenicitytoxinsanti-toxin strategiesvirulence |
| spellingShingle | Nour Ahmad-Mansour Paul Loubet Cassandra Pouget Catherine Dunyach-Remy Albert Sotto Jean-Philippe Lavigne Virginie Molle <i>Staphylococcus aureus</i> Toxins: An Update on Their Pathogenic Properties and Potential Treatments Toxins <i>Staphylococcus aureus</i> pathogenicity toxins anti-toxin strategies virulence |
| title | <i>Staphylococcus aureus</i> Toxins: An Update on Their Pathogenic Properties and Potential Treatments |
| title_full | <i>Staphylococcus aureus</i> Toxins: An Update on Their Pathogenic Properties and Potential Treatments |
| title_fullStr | <i>Staphylococcus aureus</i> Toxins: An Update on Their Pathogenic Properties and Potential Treatments |
| title_full_unstemmed | <i>Staphylococcus aureus</i> Toxins: An Update on Their Pathogenic Properties and Potential Treatments |
| title_short | <i>Staphylococcus aureus</i> Toxins: An Update on Their Pathogenic Properties and Potential Treatments |
| title_sort | i staphylococcus aureus i toxins an update on their pathogenic properties and potential treatments |
| topic | <i>Staphylococcus aureus</i> pathogenicity toxins anti-toxin strategies virulence |
| url | https://www.mdpi.com/2072-6651/13/10/677 |
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