Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors‏ on PC12 cells

Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors‏ on PC12 cells

Abstract Background The loss of cholinergic neurotransmission in Alzheimer's disease (AD) patients' brain is accompanied by a reduced concentration of Acetylcholine (ACh) within synaptic clefts. Thus, the use of acetylcholinesterase inhibitors (AChEIs) to block the cholinergic degradation...

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Bibliographic Details
Main Authors: Maryam Taheri, Samira Aslani, Hossein Ghafouri, Asadollah Mohammadi, Vaha Akbary Moghaddam, Nastarn Moradi, Hananeh Naeimi
Format: Article
Language:English
Published: BMC 2022-02-01
Series:BMC Chemistry
Subjects:
Acetylcholinesterase inhibitors
Alzheimer's disease
2-Chloro-3-hydrazinopyrazine
PC12 cells
Online Access:https://doi.org/10.1186/s13065-022-00799-w

Internet

https://doi.org/10.1186/s13065-022-00799-w

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