Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form.

Context: The modification of starch from the grains of NSICRc222 rice variety may provide a new material with enhanced disintegrating functionality in compressed solid dosage forms. Aims: To synthesize hydroxypropylated crosslinked rice starch that may possess characteristics of a good disintegra...

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Main Authors: Elizabeth A. Pagtalunan, Judson Lowie T. Ramos, Gerard Q. De Guzman
Format: Article
Language:English
Published: GarVal Editorial Ltda. 2022-07-01
Series:Journal of Pharmacy & Pharmacognosy Research
Subjects:
Online Access:https://jppres.com/jppres/pdf/vol10/jppres22.1377_10.4.701.pdf
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author Elizabeth A. Pagtalunan
Judson Lowie T. Ramos
Gerard Q. De Guzman
author_facet Elizabeth A. Pagtalunan
Judson Lowie T. Ramos
Gerard Q. De Guzman
author_sort Elizabeth A. Pagtalunan
collection DOAJ
description Context: The modification of starch from the grains of NSICRc222 rice variety may provide a new material with enhanced disintegrating functionality in compressed solid dosage forms. Aims: To synthesize hydroxypropylated crosslinked rice starch that may possess characteristics of a good disintegrant. Methods: Starch was isolated by the wet milling method. The crosslinking was performed using trisodium trimetaphosphate as crosslinking agent, and successively hydroxypropylated by using phosphorous oxychloride. The evidences of chemical modifications were determined by FTIR, TGA, and DSC. The application of modified rice starch as a disintegrant was evaluated by determining the dissolution profile, and was compared to the performance of commercially available disintegrants. The compatibility of modified rice starch was employed using FTIR, and the stability of the formulation was subjected to an accelerated stability study. Results: The changes in infrared spectra and thermogram confirmed successful chemical modification of rice starch. Allopurinol and modified starch mixture staged from 0 to 3 months showed no significant changes in the infrared spectra, which suggest compatibility of HCR with allopurinol. The dissolution rate of allopurinol tablets at pH 1.2, pH 4.5, and pH 6.8 with various superdisintegrants were comparable to the dissolution rate that utilized hydroxypropylated crosslinked rice starch as disintegrant. The accelerated stability study showed no significant changes from 0th to 3rd month, and no degradation products were detected in the HPLC analysis. Conclusions: The chemical modification of rice starch through crosslinking and hydroxypropylation yielded a novel material comparable to the commercially available superdisintegrants.
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spelling doaj.art-364fd991e95f40069df99ba0019ed00c2022-12-22T01:56:01ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502022-07-01104701716Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form.Elizabeth A. PagtalunanJudson Lowie T. RamosGerard Q. De GuzmanContext: The modification of starch from the grains of NSICRc222 rice variety may provide a new material with enhanced disintegrating functionality in compressed solid dosage forms. Aims: To synthesize hydroxypropylated crosslinked rice starch that may possess characteristics of a good disintegrant. Methods: Starch was isolated by the wet milling method. The crosslinking was performed using trisodium trimetaphosphate as crosslinking agent, and successively hydroxypropylated by using phosphorous oxychloride. The evidences of chemical modifications were determined by FTIR, TGA, and DSC. The application of modified rice starch as a disintegrant was evaluated by determining the dissolution profile, and was compared to the performance of commercially available disintegrants. The compatibility of modified rice starch was employed using FTIR, and the stability of the formulation was subjected to an accelerated stability study. Results: The changes in infrared spectra and thermogram confirmed successful chemical modification of rice starch. Allopurinol and modified starch mixture staged from 0 to 3 months showed no significant changes in the infrared spectra, which suggest compatibility of HCR with allopurinol. The dissolution rate of allopurinol tablets at pH 1.2, pH 4.5, and pH 6.8 with various superdisintegrants were comparable to the dissolution rate that utilized hydroxypropylated crosslinked rice starch as disintegrant. The accelerated stability study showed no significant changes from 0th to 3rd month, and no degradation products were detected in the HPLC analysis. Conclusions: The chemical modification of rice starch through crosslinking and hydroxypropylation yielded a novel material comparable to the commercially available superdisintegrants.https://jppres.com/jppres/pdf/vol10/jppres22.1377_10.4.701.pdfcrosslinkingdisintegranthydroxypropylationimmediate releasensic rc222-tubigan 18rice starch
spellingShingle Elizabeth A. Pagtalunan
Judson Lowie T. Ramos
Gerard Q. De Guzman
Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form.
Journal of Pharmacy & Pharmacognosy Research
crosslinking
disintegrant
hydroxypropylation
immediate release
nsic rc222-tubigan 18
rice starch
title Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form.
title_full Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form.
title_fullStr Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form.
title_full_unstemmed Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form.
title_short Application of hydroxypropylated crosslinked starch from the grains of Oryza sativa L. as potential disintegrant in compressed solid dosage form.
title_sort application of hydroxypropylated crosslinked starch from the grains of oryza sativa l as potential disintegrant in compressed solid dosage form
topic crosslinking
disintegrant
hydroxypropylation
immediate release
nsic rc222-tubigan 18
rice starch
url https://jppres.com/jppres/pdf/vol10/jppres22.1377_10.4.701.pdf
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