Quantified pathway mutations associate epithelial-mesenchymal transition and immune escape with poor prognosis and immunotherapy resistance of head and neck squamous cell carcinoma

Quantified pathway mutations associate epithelial-mesenchymal transition and immune escape with poor prognosis and immunotherapy resistance of head and neck squamous cell carcinoma

Abstract Background Pathway mutations have been calculated to predict the poor prognosis and immunotherapy resistance in head and neck squamous cell carcinoma (HNSCC). To uncover the unique markers predicting prognosis and immune therapy response, the accurate quantification of pathway mutations are...

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Bibliographic Details
Main Authors: Yuhong Huang, Han Liu, Bo Liu, Xiaoyan Chen, Danya Li, Junyuan Xue, Nan Li, Lei Zhu, Liu Yang, Jing Xiao, Chao Liu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Medical Genomics
Subjects:
Pathway Mutation Burden (PMB)
Tumor Mutation Burden (TMB)
Functional genomics
Polyomics
Transcriptome
Online Access:https://doi.org/10.1186/s12920-024-01818-6

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