Gradient Magnetic Field Accelerates Division of <i>E. coli</i> Nissle 1917
Cell-cycle progression is regulated by numerous intricate endogenous mechanisms, among which intracellular forces and protein motors are central players. Although it seems unlikely that it is possible to speed up this molecular machinery by applying tiny external forces to the cell, we show that mag...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/2/315 |
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| author | Svitlana Gorobets Oksana Gorobets Iryna Sharai Tatyana Polyakova Vitalii Zablotskii |
| author_facet | Svitlana Gorobets Oksana Gorobets Iryna Sharai Tatyana Polyakova Vitalii Zablotskii |
| author_sort | Svitlana Gorobets |
| collection | DOAJ |
| description | Cell-cycle progression is regulated by numerous intricate endogenous mechanisms, among which intracellular forces and protein motors are central players. Although it seems unlikely that it is possible to speed up this molecular machinery by applying tiny external forces to the cell, we show that magnetic forcing of magnetosensitive bacteria reduces the duration of the mitotic phase. In such bacteria, the coupling of the cell cycle to the splitting of chains of biogenic magnetic nanoparticles (BMNs) provides a biological realization of such forcing. Using a static gradient magnetic field of a special spatial configuration, in probiotic bacteria <i>E. coli</i> Nissle 1917, we shortened the duration of the mitotic phase and thereby accelerated cell division. Thus, focused magnetic gradient forces exerted on the BMN chains allowed us to intervene in the processes of division and growth of bacteria. The proposed magnetic-based cell division regulation strategy can improve the efficiency of microbial cell factories and medical applications of magnetosensitive bacteria. |
| first_indexed | 2024-03-09T13:11:23Z |
| format | Article |
| id | doaj.art-36538ed46739488a95aa138195b3da63 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T13:11:23Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-36538ed46739488a95aa138195b3da632023-11-30T21:40:45ZengMDPI AGCells2073-44092023-01-0112231510.3390/cells12020315Gradient Magnetic Field Accelerates Division of <i>E. coli</i> Nissle 1917Svitlana Gorobets0Oksana Gorobets1Iryna Sharai2Tatyana Polyakova3Vitalii Zablotskii4Faculty of Biotechnology and Biotechnics, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, 03056 Kyiv, UkraineFaculty of Physics and Mathematics, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, 03056 Kyiv, UkraineFaculty of Physics and Mathematics, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, 03056 Kyiv, UkraineInstitute of Physics of the Czech Academy of Sciences, Na Slovance 1999/2, 182 00 Prague, Czech RepublicInstitute of Physics of the Czech Academy of Sciences, Na Slovance 1999/2, 182 00 Prague, Czech RepublicCell-cycle progression is regulated by numerous intricate endogenous mechanisms, among which intracellular forces and protein motors are central players. Although it seems unlikely that it is possible to speed up this molecular machinery by applying tiny external forces to the cell, we show that magnetic forcing of magnetosensitive bacteria reduces the duration of the mitotic phase. In such bacteria, the coupling of the cell cycle to the splitting of chains of biogenic magnetic nanoparticles (BMNs) provides a biological realization of such forcing. Using a static gradient magnetic field of a special spatial configuration, in probiotic bacteria <i>E. coli</i> Nissle 1917, we shortened the duration of the mitotic phase and thereby accelerated cell division. Thus, focused magnetic gradient forces exerted on the BMN chains allowed us to intervene in the processes of division and growth of bacteria. The proposed magnetic-based cell division regulation strategy can improve the efficiency of microbial cell factories and medical applications of magnetosensitive bacteria.https://www.mdpi.com/2073-4409/12/2/315bacterial divisionmagnetic fieldbiomagnetic effectsmitosisintracellular forces |
| spellingShingle | Svitlana Gorobets Oksana Gorobets Iryna Sharai Tatyana Polyakova Vitalii Zablotskii Gradient Magnetic Field Accelerates Division of <i>E. coli</i> Nissle 1917 Cells bacterial division magnetic field biomagnetic effects mitosis intracellular forces |
| title | Gradient Magnetic Field Accelerates Division of <i>E. coli</i> Nissle 1917 |
| title_full | Gradient Magnetic Field Accelerates Division of <i>E. coli</i> Nissle 1917 |
| title_fullStr | Gradient Magnetic Field Accelerates Division of <i>E. coli</i> Nissle 1917 |
| title_full_unstemmed | Gradient Magnetic Field Accelerates Division of <i>E. coli</i> Nissle 1917 |
| title_short | Gradient Magnetic Field Accelerates Division of <i>E. coli</i> Nissle 1917 |
| title_sort | gradient magnetic field accelerates division of i e coli i nissle 1917 |
| topic | bacterial division magnetic field biomagnetic effects mitosis intracellular forces |
| url | https://www.mdpi.com/2073-4409/12/2/315 |
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