Post-Mortem diagnosis of dementia by informant interview
Abstract The diagnosis of normal cognition or dementia in the Brazilian Brain Bank of the Aging Brain Study Group (BBBABSG) has relied on postmortem interview with an informant. Objectives: To ascertain the sensitivity and specificity of postmortem diagnosis based on informant interview compared ag...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
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| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000200138&lng=en&tlng=en |
| _version_ | 1818508083498844160 |
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| author | Renata Eloah de Lucena Ferretti Antonio Eduardo Damin Sonia Maria Dozzi Brucki Lilian Schafirovits Morillo Tibor Rilho Perroco Flávia Campora Eliza Guccione Moreira Érika Silvério Balbino Maria do Carmo de Ascenção Lima Camila Battela Lumena Ruiz Lea Tenenholz Grinberg José Marcelo Farfel Renata Elaine Paraiso Leite Claudia Kimie Suemoto Carlos Augusto Pasqualucci Sérgio Rosemberg Paulo Hilário Nascimento Saldiva Wilson Jacob-Filho Ricardo Nitrini |
| author_facet | Renata Eloah de Lucena Ferretti Antonio Eduardo Damin Sonia Maria Dozzi Brucki Lilian Schafirovits Morillo Tibor Rilho Perroco Flávia Campora Eliza Guccione Moreira Érika Silvério Balbino Maria do Carmo de Ascenção Lima Camila Battela Lumena Ruiz Lea Tenenholz Grinberg José Marcelo Farfel Renata Elaine Paraiso Leite Claudia Kimie Suemoto Carlos Augusto Pasqualucci Sérgio Rosemberg Paulo Hilário Nascimento Saldiva Wilson Jacob-Filho Ricardo Nitrini |
| author_sort | Renata Eloah de Lucena Ferretti |
| collection | DOAJ |
| description | Abstract The diagnosis of normal cognition or dementia in the Brazilian Brain Bank of the Aging Brain Study Group (BBBABSG) has relied on postmortem interview with an informant. Objectives: To ascertain the sensitivity and specificity of postmortem diagnosis based on informant interview compared against the diagnosis established at a memory clinic. Methods: A prospective study was conducted at the BBBABSG and at the Reference Center for Cognitive Disorders (RCCD), a specialized memory clinic of the Hospital das Clínicas, University of São Paulo Medical School. Control subjects and cognitively impaired subjects were referred from the Hospital das Clínicas to the RCCD where subjects and their informants were assessed. The same informant was then interviewed at the BBBABSG. Specialists' panel consensus, in each group, determined the final diagnosis of the case, blind to other center's diagnosis. Data was compared for frequency of diagnostic equivalence. For this study, the diagnosis established at the RCCD was accepted as the gold standard. Sensitivity and specificity were computed. Results: Ninety individuals were included, 45 with dementia and 45 without dementia (26 cognitively normal and 19 cognitively impaired but non-demented). The informant interview at the BBBABSG had a sensitivity of 86.6% and specificity of 84.4% for the diagnosis of dementia, and a sensitivity of 65.3% and specificity of 93.7% for the diagnosis of normal cognition. Conclusions: The informant interview used at the BBBABSG has a high specificity and sensitivity for the diagnosis of dementia as well as a high specificity for the diagnosis of normal cognition. |
| first_indexed | 2024-12-10T22:26:55Z |
| format | Article |
| id | doaj.art-36544ffb2c3d4c09b7591228fd37ba95 |
| institution | Directory Open Access Journal |
| issn | 1980-5764 |
| language | English |
| last_indexed | 2024-12-10T22:26:55Z |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj.art-36544ffb2c3d4c09b7591228fd37ba952022-12-22T01:31:08ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57644213814410.1590/S1980-57642010DN40200011S1980-57642010000200138Post-Mortem diagnosis of dementia by informant interviewRenata Eloah de Lucena FerrettiAntonio Eduardo DaminSonia Maria Dozzi BruckiLilian Schafirovits MorilloTibor Rilho PerrocoFlávia CamporaEliza Guccione MoreiraÉrika Silvério BalbinoMaria do Carmo de Ascenção LimaCamila BattelaLumena RuizLea Tenenholz GrinbergJosé Marcelo FarfelRenata Elaine Paraiso LeiteClaudia Kimie SuemotoCarlos Augusto PasqualucciSérgio RosembergPaulo Hilário Nascimento SaldivaWilson Jacob-FilhoRicardo NitriniAbstract The diagnosis of normal cognition or dementia in the Brazilian Brain Bank of the Aging Brain Study Group (BBBABSG) has relied on postmortem interview with an informant. Objectives: To ascertain the sensitivity and specificity of postmortem diagnosis based on informant interview compared against the diagnosis established at a memory clinic. Methods: A prospective study was conducted at the BBBABSG and at the Reference Center for Cognitive Disorders (RCCD), a specialized memory clinic of the Hospital das Clínicas, University of São Paulo Medical School. Control subjects and cognitively impaired subjects were referred from the Hospital das Clínicas to the RCCD where subjects and their informants were assessed. The same informant was then interviewed at the BBBABSG. Specialists' panel consensus, in each group, determined the final diagnosis of the case, blind to other center's diagnosis. Data was compared for frequency of diagnostic equivalence. For this study, the diagnosis established at the RCCD was accepted as the gold standard. Sensitivity and specificity were computed. Results: Ninety individuals were included, 45 with dementia and 45 without dementia (26 cognitively normal and 19 cognitively impaired but non-demented). The informant interview at the BBBABSG had a sensitivity of 86.6% and specificity of 84.4% for the diagnosis of dementia, and a sensitivity of 65.3% and specificity of 93.7% for the diagnosis of normal cognition. Conclusions: The informant interview used at the BBBABSG has a high specificity and sensitivity for the diagnosis of dementia as well as a high specificity for the diagnosis of normal cognition.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000200138&lng=en&tlng=enbrain bankpostmortem diagnosisdementiaaginginformant-interview. |
| spellingShingle | Renata Eloah de Lucena Ferretti Antonio Eduardo Damin Sonia Maria Dozzi Brucki Lilian Schafirovits Morillo Tibor Rilho Perroco Flávia Campora Eliza Guccione Moreira Érika Silvério Balbino Maria do Carmo de Ascenção Lima Camila Battela Lumena Ruiz Lea Tenenholz Grinberg José Marcelo Farfel Renata Elaine Paraiso Leite Claudia Kimie Suemoto Carlos Augusto Pasqualucci Sérgio Rosemberg Paulo Hilário Nascimento Saldiva Wilson Jacob-Filho Ricardo Nitrini Post-Mortem diagnosis of dementia by informant interview Dementia & Neuropsychologia brain bank postmortem diagnosis dementia aging informant-interview. |
| title | Post-Mortem diagnosis of dementia by informant interview |
| title_full | Post-Mortem diagnosis of dementia by informant interview |
| title_fullStr | Post-Mortem diagnosis of dementia by informant interview |
| title_full_unstemmed | Post-Mortem diagnosis of dementia by informant interview |
| title_short | Post-Mortem diagnosis of dementia by informant interview |
| title_sort | post mortem diagnosis of dementia by informant interview |
| topic | brain bank postmortem diagnosis dementia aging informant-interview. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642010000200138&lng=en&tlng=en |
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