Clinical Outcomes of Adult Patients Hospitalized with COVID-19 after Vaccination
Vaccination remains the most effective way to prevent COVID-19. The aim of the present study was to assess the incidence of COVID-19 hospitalizations after vaccination, as well as the effect of prior vaccination on hospitalization outcomes among patients with COVID-19. We analyzed and compared all c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Tropical Medicine and Infectious Disease |
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| Online Access: | https://www.mdpi.com/2414-6366/6/4/175 |
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| author | Markos Kalligeros Fadi Shehadeh Evangelia K. Mylona Matthew Kaczynski Saisanjana Kalagara Eleftheria Atalla Maria Tsikala Vafea Eleftherios Mylonakis |
| author_facet | Markos Kalligeros Fadi Shehadeh Evangelia K. Mylona Matthew Kaczynski Saisanjana Kalagara Eleftheria Atalla Maria Tsikala Vafea Eleftherios Mylonakis |
| author_sort | Markos Kalligeros |
| collection | DOAJ |
| description | Vaccination remains the most effective way to prevent COVID-19. The aim of the present study was to assess the incidence of COVID-19 hospitalizations after vaccination, as well as the effect of prior vaccination on hospitalization outcomes among patients with COVID-19. We analyzed and compared all consecutive patients, with or without prior vaccination, who were admitted to our hospital network due to COVID-19 from January to April 2021. Our primary outcome was to identify and describe cases of COVID-19 hospitalized after vaccination. We also utilized a multivariate logistic regression model to investigate the association of previous vaccination with hospitalization outcomes. We identified 915 consecutive patients hospitalized due to COVID-19 with 91/915 (10%) previously vaccinated with at least one dose of a COVID-19 vaccine. Utilizing our multivariate logistic regression model, we found that prior vaccination, regardless of the number of doses or days since vaccination, was associated with decreased mortality (aOR 0.44, 95% CI: 0.20–0.98) when compared to unvaccinated individuals. Our study showed that COVID-19 related hospitalization after vaccination may occur to a small percentage of patients, mainly those who are partially vaccinated. However, our findings underline that prior vaccination, even when partial, is associated with a decreased risk of death. Ongoing vaccination efforts should remain an absolute priority. |
| first_indexed | 2024-03-10T03:57:49Z |
| format | Article |
| id | doaj.art-365468c7f7b4469ca8fa1969afc91c73 |
| institution | Directory Open Access Journal |
| issn | 2414-6366 |
| language | English |
| last_indexed | 2024-03-10T03:57:49Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Tropical Medicine and Infectious Disease |
| spelling | doaj.art-365468c7f7b4469ca8fa1969afc91c732023-11-23T10:51:40ZengMDPI AGTropical Medicine and Infectious Disease2414-63662021-09-016417510.3390/tropicalmed6040175Clinical Outcomes of Adult Patients Hospitalized with COVID-19 after VaccinationMarkos Kalligeros0Fadi Shehadeh1Evangelia K. Mylona2Matthew Kaczynski3Saisanjana Kalagara4Eleftheria Atalla5Maria Tsikala Vafea6Eleftherios Mylonakis7Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USAInfectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USAInfectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USAInfectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USAInfectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USAInfectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USAInfectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USAInfectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USAVaccination remains the most effective way to prevent COVID-19. The aim of the present study was to assess the incidence of COVID-19 hospitalizations after vaccination, as well as the effect of prior vaccination on hospitalization outcomes among patients with COVID-19. We analyzed and compared all consecutive patients, with or without prior vaccination, who were admitted to our hospital network due to COVID-19 from January to April 2021. Our primary outcome was to identify and describe cases of COVID-19 hospitalized after vaccination. We also utilized a multivariate logistic regression model to investigate the association of previous vaccination with hospitalization outcomes. We identified 915 consecutive patients hospitalized due to COVID-19 with 91/915 (10%) previously vaccinated with at least one dose of a COVID-19 vaccine. Utilizing our multivariate logistic regression model, we found that prior vaccination, regardless of the number of doses or days since vaccination, was associated with decreased mortality (aOR 0.44, 95% CI: 0.20–0.98) when compared to unvaccinated individuals. Our study showed that COVID-19 related hospitalization after vaccination may occur to a small percentage of patients, mainly those who are partially vaccinated. However, our findings underline that prior vaccination, even when partial, is associated with a decreased risk of death. Ongoing vaccination efforts should remain an absolute priority.https://www.mdpi.com/2414-6366/6/4/175COVID-19SARS-COV-2vaccinationbreakthrough infections |
| spellingShingle | Markos Kalligeros Fadi Shehadeh Evangelia K. Mylona Matthew Kaczynski Saisanjana Kalagara Eleftheria Atalla Maria Tsikala Vafea Eleftherios Mylonakis Clinical Outcomes of Adult Patients Hospitalized with COVID-19 after Vaccination Tropical Medicine and Infectious Disease COVID-19 SARS-COV-2 vaccination breakthrough infections |
| title | Clinical Outcomes of Adult Patients Hospitalized with COVID-19 after Vaccination |
| title_full | Clinical Outcomes of Adult Patients Hospitalized with COVID-19 after Vaccination |
| title_fullStr | Clinical Outcomes of Adult Patients Hospitalized with COVID-19 after Vaccination |
| title_full_unstemmed | Clinical Outcomes of Adult Patients Hospitalized with COVID-19 after Vaccination |
| title_short | Clinical Outcomes of Adult Patients Hospitalized with COVID-19 after Vaccination |
| title_sort | clinical outcomes of adult patients hospitalized with covid 19 after vaccination |
| topic | COVID-19 SARS-COV-2 vaccination breakthrough infections |
| url | https://www.mdpi.com/2414-6366/6/4/175 |
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