P450 Pharmacogenetics in Indigenous North American Populations
Indigenous North American populations, including American Indian and Alaska Native peoples in the United States, the First Nations, Métis and Inuit peoples in Canada and Amerindians in Mexico, are historically under-represented in biomedical research, including genomic research on drug disposition a...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-02-01
|
| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-4426/8/1/9 |
| _version_ | 1797757881735446528 |
|---|---|
| author | Lindsay M. Henderson Katrina G. Claw Erica L. Woodahl Renee F. Robinson Bert B. Boyer Wylie Burke Kenneth E. Thummel |
| author_facet | Lindsay M. Henderson Katrina G. Claw Erica L. Woodahl Renee F. Robinson Bert B. Boyer Wylie Burke Kenneth E. Thummel |
| author_sort | Lindsay M. Henderson |
| collection | DOAJ |
| description | Indigenous North American populations, including American Indian and Alaska Native peoples in the United States, the First Nations, Métis and Inuit peoples in Canada and Amerindians in Mexico, are historically under-represented in biomedical research, including genomic research on drug disposition and response. Without adequate representation in pharmacogenetic studies establishing genotype-phenotype relationships, Indigenous populations may not benefit fully from new innovations in precision medicine testing to tailor and improve the safety and efficacy of drug treatment, resulting in health care disparities. The purpose of this review is to summarize and evaluate what is currently known about cytochrome P450 genetic variation in Indigenous populations in North America and to highlight the importance of including these groups in future pharmacogenetic studies for implementation of personalized drug therapy. |
| first_indexed | 2024-03-12T18:21:56Z |
| format | Article |
| id | doaj.art-3654b0c93e0d429bb4334d0ff6ad69b3 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-12T18:21:56Z |
| publishDate | 2018-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-3654b0c93e0d429bb4334d0ff6ad69b32023-08-02T08:48:54ZengMDPI AGJournal of Personalized Medicine2075-44262018-02-0181910.3390/jpm8010009jpm8010009P450 Pharmacogenetics in Indigenous North American PopulationsLindsay M. Henderson0Katrina G. Claw1Erica L. Woodahl2Renee F. Robinson3Bert B. Boyer4Wylie Burke5Kenneth E. Thummel6Departments of Pharmaceutics, University of Washington, Seattle, WA 98195, USADepartments of Pharmaceutics, University of Washington, Seattle, WA 98195, USADepartment of Biomedical and Pharmaceutical Sciences, University of Montana, Missoula, MT 59812, USASouthcentral Foundation, Anchorage, AK 99508, USACenter for Alaska Native Health Research, University of Alaska Fairbanks, Fairbanks, AK 99775, USABioethics & Humanities, University of Washington, Seattle, WA 98195, USADepartments of Pharmaceutics, University of Washington, Seattle, WA 98195, USAIndigenous North American populations, including American Indian and Alaska Native peoples in the United States, the First Nations, Métis and Inuit peoples in Canada and Amerindians in Mexico, are historically under-represented in biomedical research, including genomic research on drug disposition and response. Without adequate representation in pharmacogenetic studies establishing genotype-phenotype relationships, Indigenous populations may not benefit fully from new innovations in precision medicine testing to tailor and improve the safety and efficacy of drug treatment, resulting in health care disparities. The purpose of this review is to summarize and evaluate what is currently known about cytochrome P450 genetic variation in Indigenous populations in North America and to highlight the importance of including these groups in future pharmacogenetic studies for implementation of personalized drug therapy.http://www.mdpi.com/2075-4426/8/1/9American IndianAlaska NativeFirst NationsInuitMexican Amerindianscytochrome P450pharmacogeneticsallele frequencydrug metabolism |
| spellingShingle | Lindsay M. Henderson Katrina G. Claw Erica L. Woodahl Renee F. Robinson Bert B. Boyer Wylie Burke Kenneth E. Thummel P450 Pharmacogenetics in Indigenous North American Populations Journal of Personalized Medicine American Indian Alaska Native First Nations Inuit Mexican Amerindians cytochrome P450 pharmacogenetics allele frequency drug metabolism |
| title | P450 Pharmacogenetics in Indigenous North American Populations |
| title_full | P450 Pharmacogenetics in Indigenous North American Populations |
| title_fullStr | P450 Pharmacogenetics in Indigenous North American Populations |
| title_full_unstemmed | P450 Pharmacogenetics in Indigenous North American Populations |
| title_short | P450 Pharmacogenetics in Indigenous North American Populations |
| title_sort | p450 pharmacogenetics in indigenous north american populations |
| topic | American Indian Alaska Native First Nations Inuit Mexican Amerindians cytochrome P450 pharmacogenetics allele frequency drug metabolism |
| url | http://www.mdpi.com/2075-4426/8/1/9 |
| work_keys_str_mv | AT lindsaymhenderson p450pharmacogeneticsinindigenousnorthamericanpopulations AT katrinagclaw p450pharmacogeneticsinindigenousnorthamericanpopulations AT ericalwoodahl p450pharmacogeneticsinindigenousnorthamericanpopulations AT reneefrobinson p450pharmacogeneticsinindigenousnorthamericanpopulations AT bertbboyer p450pharmacogeneticsinindigenousnorthamericanpopulations AT wylieburke p450pharmacogeneticsinindigenousnorthamericanpopulations AT kennethethummel p450pharmacogeneticsinindigenousnorthamericanpopulations |