Development and Evaluation of Sodium Alginate/Carbopol 934P-Co-Poly (Methacrylate) Hydrogels for Localized Drug Delivery
This research was carried out to create a pH-responsive polymeric system for the targeted drug delivery of Diloxanide furoate. It relied on sodium alginate (Na-Alg) and Carbopol 934P as building blocks. Using an aqueous free radical polymerization method, SCH1-SCH12 was created with varying polymer,...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/2/311 |
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| author | Ayesha Mahmood Asif Mahmood Mohamed A. Ibrahim Zahid Hussain Muhammad Umar Ashraf Mounir M. Salem-Bekhit Ibrahim Elbagory |
| author_facet | Ayesha Mahmood Asif Mahmood Mohamed A. Ibrahim Zahid Hussain Muhammad Umar Ashraf Mounir M. Salem-Bekhit Ibrahim Elbagory |
| author_sort | Ayesha Mahmood |
| collection | DOAJ |
| description | This research was carried out to create a pH-responsive polymeric system for the targeted drug delivery of Diloxanide furoate. It relied on sodium alginate (Na-Alg) and Carbopol 934P as building blocks. Using an aqueous free radical polymerization method, SCH1-SCH12 was created with varying polymer, MAA, and MBA input ratios. Positive outcomes were seen in the swelling and release profiles at higher pH levels. Hydrogel formation, as well as component compatibility, thermal stability, and Diloxanide furoate loading, were all validated by instrumental characterization. A drug loading percentage of 83.56% was determined, with the swelling reaching 743.19%. For the formulation with MBA, the gel fraction was 94.58%. The release of diloxanide furoate increased to 91.77% at neutral pH. The formulation containing Carbopol 934P provided the highest mucoadhesion force (3993.42 dynes/cm<sup>2</sup>). The created hydrogel has been shown to be biocompatible by toxicological testing of the network. Based on the findings, the created polymeric nexus proved promising for pH-dependent localized and regulated delivery of Diloxanide furoate. |
| first_indexed | 2024-03-09T11:24:11Z |
| format | Article |
| id | doaj.art-3656f893fb9e424fb736a1def74cce2c |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T11:24:11Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-3656f893fb9e424fb736a1def74cce2c2023-12-01T00:07:53ZengMDPI AGPolymers2073-43602023-01-0115231110.3390/polym15020311Development and Evaluation of Sodium Alginate/Carbopol 934P-Co-Poly (Methacrylate) Hydrogels for Localized Drug DeliveryAyesha Mahmood0Asif Mahmood1Mohamed A. Ibrahim2Zahid Hussain3Muhammad Umar Ashraf4Mounir M. Salem-Bekhit5Ibrahim Elbagory6Faculty of Pharmacy, University of Lahore, Lahore 5400, PakistanFaculty of Pharmacy, University of Lahore, Lahore 5400, PakistanDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaDepartment of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, University of Sharjah, Sharjah 27272, United Arab EmiratesFaculty of Pharmacy, University of Lahore, Lahore 5400, PakistanDepartment of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi ArabiaCollege of Pharmacy, Northern Border University, Arar 1321, Saudi ArabiaThis research was carried out to create a pH-responsive polymeric system for the targeted drug delivery of Diloxanide furoate. It relied on sodium alginate (Na-Alg) and Carbopol 934P as building blocks. Using an aqueous free radical polymerization method, SCH1-SCH12 was created with varying polymer, MAA, and MBA input ratios. Positive outcomes were seen in the swelling and release profiles at higher pH levels. Hydrogel formation, as well as component compatibility, thermal stability, and Diloxanide furoate loading, were all validated by instrumental characterization. A drug loading percentage of 83.56% was determined, with the swelling reaching 743.19%. For the formulation with MBA, the gel fraction was 94.58%. The release of diloxanide furoate increased to 91.77% at neutral pH. The formulation containing Carbopol 934P provided the highest mucoadhesion force (3993.42 dynes/cm<sup>2</sup>). The created hydrogel has been shown to be biocompatible by toxicological testing of the network. Based on the findings, the created polymeric nexus proved promising for pH-dependent localized and regulated delivery of Diloxanide furoate.https://www.mdpi.com/2073-4360/15/2/311diloxanide furoatesodium alginateCarbopol 934Plocalized deliveryfree radical polymerization |
| spellingShingle | Ayesha Mahmood Asif Mahmood Mohamed A. Ibrahim Zahid Hussain Muhammad Umar Ashraf Mounir M. Salem-Bekhit Ibrahim Elbagory Development and Evaluation of Sodium Alginate/Carbopol 934P-Co-Poly (Methacrylate) Hydrogels for Localized Drug Delivery Polymers diloxanide furoate sodium alginate Carbopol 934P localized delivery free radical polymerization |
| title | Development and Evaluation of Sodium Alginate/Carbopol 934P-Co-Poly (Methacrylate) Hydrogels for Localized Drug Delivery |
| title_full | Development and Evaluation of Sodium Alginate/Carbopol 934P-Co-Poly (Methacrylate) Hydrogels for Localized Drug Delivery |
| title_fullStr | Development and Evaluation of Sodium Alginate/Carbopol 934P-Co-Poly (Methacrylate) Hydrogels for Localized Drug Delivery |
| title_full_unstemmed | Development and Evaluation of Sodium Alginate/Carbopol 934P-Co-Poly (Methacrylate) Hydrogels for Localized Drug Delivery |
| title_short | Development and Evaluation of Sodium Alginate/Carbopol 934P-Co-Poly (Methacrylate) Hydrogels for Localized Drug Delivery |
| title_sort | development and evaluation of sodium alginate carbopol 934p co poly methacrylate hydrogels for localized drug delivery |
| topic | diloxanide furoate sodium alginate Carbopol 934P localized delivery free radical polymerization |
| url | https://www.mdpi.com/2073-4360/15/2/311 |
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