Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood
The aim was to determine which adult type 1 diabetic patient receiving multiple daily injection therapy is the most appropriate candidate for insulin pump therapy, while taking into consideration limited insulin pump affordability in Croatia. A total of 145 type 1 diabetic patients (52% diagnosed in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2016-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/237763 |
| _version_ | 1827283138891481088 |
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| author | Maja Baretić Ivana Kraljević Ivana Pavlić Renar |
| author_facet | Maja Baretić Ivana Kraljević Ivana Pavlić Renar |
| author_sort | Maja Baretić |
| collection | DOAJ |
| description | The aim was to determine which adult type 1 diabetic patient receiving multiple daily injection therapy is the most appropriate candidate for insulin pump therapy, while taking into consideration limited insulin pump affordability in Croatia. A total of 145 type 1 diabetic patients (52% diagnosed in adult age) were monitored at the Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center from 2009 to 2014. Twenty-one patients started insulin pump therapy in adulthood (seven men and 14 women, median age 27). Five patients had chronic complications (retinopathy in two, polyneuropathy in one, and both nephropathy and retinopathy in two patients). The median HbA1c at the initiation of pump therapy was 6.95% versus 6.5% after 1 year of pump therapy. Patients were stratified according to indications for
insulin pump therapy (frequent and/or severe hypoglycemia, specific lifestyle, having not reached glycemic goals despite adherence/labile diabetes, and preconception). Patients could meet more than one criterion. Initially, the occurrence of hypoglycemia was analyzed by 6-day continuous glucose monitoring, while re-evaluation was done after collecting history data at 1 year ± 3 months. Initially, all patients had a median of 5 hypoglycemias/6 days (30% nocturnal) versus 1 hypoglycemia/6 days (without nocturnal) after 1 year. The Wilcoxon signed-rank test yielded a statistically significant difference in hypoglycemic events, nocturnal hypoglycemia and HbA1c. Patients commencing insulin pump therapy due to hypoglycemia initially had median HbA1c of 6.7% with 7 hypoglycemia/6 days (50% nocturnal). After one year, median HbA1c was 6% with 1 hypoglycemia/6 days (without nocturnal). In conclusion, the main indication for insulin pump therapy in adults is the frequency of hypoglycemia, especially nocturnal ones. |
| first_indexed | 2024-04-24T09:30:45Z |
| format | Article |
| id | doaj.art-3657e5ca2a994117b06113019911b5e1 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:30:45Z |
| publishDate | 2016-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-3657e5ca2a994117b06113019911b5e12024-04-15T13:54:00ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512016-01-0155.1.939810.20471/acc.2016.55.01.14Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in AdulthoodMaja Baretić0Ivana Kraljević1Ivana Pavlić Renar2Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, CroatiaDepartment of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, CroatiaDepartment of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center, Zagreb, CroatiaThe aim was to determine which adult type 1 diabetic patient receiving multiple daily injection therapy is the most appropriate candidate for insulin pump therapy, while taking into consideration limited insulin pump affordability in Croatia. A total of 145 type 1 diabetic patients (52% diagnosed in adult age) were monitored at the Department of Endocrinology, Clinical Department of Internal Medicine, Zagreb University Hospital Center from 2009 to 2014. Twenty-one patients started insulin pump therapy in adulthood (seven men and 14 women, median age 27). Five patients had chronic complications (retinopathy in two, polyneuropathy in one, and both nephropathy and retinopathy in two patients). The median HbA1c at the initiation of pump therapy was 6.95% versus 6.5% after 1 year of pump therapy. Patients were stratified according to indications for insulin pump therapy (frequent and/or severe hypoglycemia, specific lifestyle, having not reached glycemic goals despite adherence/labile diabetes, and preconception). Patients could meet more than one criterion. Initially, the occurrence of hypoglycemia was analyzed by 6-day continuous glucose monitoring, while re-evaluation was done after collecting history data at 1 year ± 3 months. Initially, all patients had a median of 5 hypoglycemias/6 days (30% nocturnal) versus 1 hypoglycemia/6 days (without nocturnal) after 1 year. The Wilcoxon signed-rank test yielded a statistically significant difference in hypoglycemic events, nocturnal hypoglycemia and HbA1c. Patients commencing insulin pump therapy due to hypoglycemia initially had median HbA1c of 6.7% with 7 hypoglycemia/6 days (50% nocturnal). After one year, median HbA1c was 6% with 1 hypoglycemia/6 days (without nocturnal). In conclusion, the main indication for insulin pump therapy in adults is the frequency of hypoglycemia, especially nocturnal ones.https://hrcak.srce.hr/file/237763Diabetes mellitus, type 1 – complicationsHypoglycemia prevention and controlInsulin – pump administration and dosageInsulin infusion systemsInsulin pumpAdult |
| spellingShingle | Maja Baretić Ivana Kraljević Ivana Pavlić Renar Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood Acta Clinica Croatica Diabetes mellitus, type 1 – complications Hypoglycemia prevention and control Insulin – pump administration and dosage Insulin infusion systems Insulin pump Adult |
| title | Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood |
| title_full | Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood |
| title_fullStr | Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood |
| title_full_unstemmed | Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood |
| title_short | Nocturnal Hypoglycemia – The Main Indication for Insulin Pump Therapy in Adulthood |
| title_sort | nocturnal hypoglycemia the main indication for insulin pump therapy in adulthood |
| topic | Diabetes mellitus, type 1 – complications Hypoglycemia prevention and control Insulin – pump administration and dosage Insulin infusion systems Insulin pump Adult |
| url | https://hrcak.srce.hr/file/237763 |
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