Antioxidant and Anti-Atherogenic Activities of Essential Oils from <i>Myrtus communis</i> L. and <i>Laurus nobilis</i> L. in Rat
Essential oils (EOs) from aromatic and medicinal plants, such as myrtle (<i>Myrtus communis</i> L.) and Laurel (<i>Laurus nobilis</i> L.), are gaining popularity as a potential ingredient in functional foods and nutraceuticals. This study aims to investigate whether the essen...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/7/1465 |
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| author | Dyana Odeh Nada Oršolić Marija Berendika Domagoj Đikić Sandra Domjanić Drozdek Sandra Balbino Maja Repajić Verica Dragović-Uzelac Irena Landeka Jurčević |
| author_facet | Dyana Odeh Nada Oršolić Marija Berendika Domagoj Đikić Sandra Domjanić Drozdek Sandra Balbino Maja Repajić Verica Dragović-Uzelac Irena Landeka Jurčević |
| author_sort | Dyana Odeh |
| collection | DOAJ |
| description | Essential oils (EOs) from aromatic and medicinal plants, such as myrtle (<i>Myrtus communis</i> L.) and Laurel (<i>Laurus nobilis</i> L.), are gaining popularity as a potential ingredient in functional foods and nutraceuticals. This study aims to investigate whether the essential oils (EOs) could be effective in weight control, antioxidative and antilipidemic status of rats by affecting microbiota and its enzymes activity and whether changes in intestinal enzyme activity affect the health of rats. The intragastric application of laurel and myrtle EOs to rats for two weeks affects weight loss, reduces glycolytic activity, lipid parameters (cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C)) and atherogenic indicators, leading to cardiovascular protection. Laurel EO can be an excellent candidate for the treatment of drug-induced obesity and related diseases, since it affects lipid metabolism in the liver and inhibits the enzymes responsible for the metabolism of carbohydrates into glucose in the digestive tract, leading to weight loss. In contrast, myrtle EO shows a better antioxidant capacity in most tissues, except kidneys, where it causes a pro-oxidative effect, compared to laurel EO. Myrtle EO increases the permeability and instability of the erythrocyte membrane, resulting in a loss of selectivity for the entry of toxic substances into the cell. On the other hand, myrtle EO leads to intestinal inflammation by reducing the number of probiotic bacteria and increasing <i>Enterobacter</i>. |
| first_indexed | 2024-03-09T11:32:24Z |
| format | Article |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T11:32:24Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-36585bc012d242a0ac298e55f6ca55402023-11-30T23:48:38ZengMDPI AGNutrients2072-66432022-03-01147146510.3390/nu14071465Antioxidant and Anti-Atherogenic Activities of Essential Oils from <i>Myrtus communis</i> L. and <i>Laurus nobilis</i> L. in RatDyana Odeh0Nada Oršolić1Marija Berendika2Domagoj Đikić3Sandra Domjanić Drozdek4Sandra Balbino5Maja Repajić6Verica Dragović-Uzelac7Irena Landeka Jurčević8Department of Animal Physiology, Faculty of Science, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Animal Physiology, Faculty of Science, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Food Quality Control, Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Animal Physiology, Faculty of Science, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Food Quality Control, Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Food Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Food Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, CroatiaDepartment of Food Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, CroatiaLaboratory of Chemistry and Food Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, CroatiaEssential oils (EOs) from aromatic and medicinal plants, such as myrtle (<i>Myrtus communis</i> L.) and Laurel (<i>Laurus nobilis</i> L.), are gaining popularity as a potential ingredient in functional foods and nutraceuticals. This study aims to investigate whether the essential oils (EOs) could be effective in weight control, antioxidative and antilipidemic status of rats by affecting microbiota and its enzymes activity and whether changes in intestinal enzyme activity affect the health of rats. The intragastric application of laurel and myrtle EOs to rats for two weeks affects weight loss, reduces glycolytic activity, lipid parameters (cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C)) and atherogenic indicators, leading to cardiovascular protection. Laurel EO can be an excellent candidate for the treatment of drug-induced obesity and related diseases, since it affects lipid metabolism in the liver and inhibits the enzymes responsible for the metabolism of carbohydrates into glucose in the digestive tract, leading to weight loss. In contrast, myrtle EO shows a better antioxidant capacity in most tissues, except kidneys, where it causes a pro-oxidative effect, compared to laurel EO. Myrtle EO increases the permeability and instability of the erythrocyte membrane, resulting in a loss of selectivity for the entry of toxic substances into the cell. On the other hand, myrtle EO leads to intestinal inflammation by reducing the number of probiotic bacteria and increasing <i>Enterobacter</i>.https://www.mdpi.com/2072-6643/14/7/1465myrtle and laurel essential oilslipid parametersatherogenic indicatorsantioxidative activity in tissueantiatherogenic activity |
| spellingShingle | Dyana Odeh Nada Oršolić Marija Berendika Domagoj Đikić Sandra Domjanić Drozdek Sandra Balbino Maja Repajić Verica Dragović-Uzelac Irena Landeka Jurčević Antioxidant and Anti-Atherogenic Activities of Essential Oils from <i>Myrtus communis</i> L. and <i>Laurus nobilis</i> L. in Rat Nutrients myrtle and laurel essential oils lipid parameters atherogenic indicators antioxidative activity in tissue antiatherogenic activity |
| title | Antioxidant and Anti-Atherogenic Activities of Essential Oils from <i>Myrtus communis</i> L. and <i>Laurus nobilis</i> L. in Rat |
| title_full | Antioxidant and Anti-Atherogenic Activities of Essential Oils from <i>Myrtus communis</i> L. and <i>Laurus nobilis</i> L. in Rat |
| title_fullStr | Antioxidant and Anti-Atherogenic Activities of Essential Oils from <i>Myrtus communis</i> L. and <i>Laurus nobilis</i> L. in Rat |
| title_full_unstemmed | Antioxidant and Anti-Atherogenic Activities of Essential Oils from <i>Myrtus communis</i> L. and <i>Laurus nobilis</i> L. in Rat |
| title_short | Antioxidant and Anti-Atherogenic Activities of Essential Oils from <i>Myrtus communis</i> L. and <i>Laurus nobilis</i> L. in Rat |
| title_sort | antioxidant and anti atherogenic activities of essential oils from i myrtus communis i l and i laurus nobilis i l in rat |
| topic | myrtle and laurel essential oils lipid parameters atherogenic indicators antioxidative activity in tissue antiatherogenic activity |
| url | https://www.mdpi.com/2072-6643/14/7/1465 |
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