Daptomycin as supportive treatment option in patients developing mediastinitis after open cardiac surgery
<p>Abstract</p> <p>Background</p> <p>Mediastinitis is a severe complication after cardiac surgery. While improvement of prophylaxis and of medical and surgical therapy has reduced its incidence, the treatment of mediastinitis continues to be a challenging problem. Withi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-09-01
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| Series: | Journal of Cardiothoracic Surgery |
| Subjects: | |
| Online Access: | http://www.cardiothoracicsurgery.org/content/7/1/81 |
| _version_ | 1819030284419465216 |
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| author | Weis Florian Heyn Jens Hinske Christian L Vogt Ferdinand Weis Marion Kur Felix Hagl Christian Beiras-Fernandez Andres |
| author_facet | Weis Florian Heyn Jens Hinske Christian L Vogt Ferdinand Weis Marion Kur Felix Hagl Christian Beiras-Fernandez Andres |
| author_sort | Weis Florian |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Mediastinitis is a severe complication after cardiac surgery. While improvement of prophylaxis and of medical and surgical therapy has reduced its incidence, the treatment of mediastinitis continues to be a challenging problem. Within this study, we report the successful use of daptomycin as supportive therapy in patients developing mediastinitis after open cardiac surgery.</p> <p>Methods</p> <p>The records of 21 consecutive patients who developed mediastinitis after cardiac surgery were retrospectively reviewed. After diagnosis, all patients received surgical debridement and antibiotic therapy with daptomycin. All patients were followed up to death or discharge.</p> <p>Results</p> <p>Clinical improvement after combined surgical and antibiotic therapy with daptomycin was found in 90.5% of the patients. The median time until clinical improvement occurred was 5 [4/6] days. Daptomycin was well-tolerated and no major adverse events during therapy were observed observed.</p> <p>Conclusions</p> <p>This study provides new and helpful information regarding the beneficial use of daptomycin as supportive treatment option in patients developing mediastinitis after cardiac surgery.</p> |
| first_indexed | 2024-12-21T06:27:42Z |
| format | Article |
| id | doaj.art-365ae76f903847a781edaabdab0c4317 |
| institution | Directory Open Access Journal |
| issn | 1749-8090 |
| language | English |
| last_indexed | 2024-12-21T06:27:42Z |
| publishDate | 2012-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj.art-365ae76f903847a781edaabdab0c43172022-12-21T19:13:04ZengBMCJournal of Cardiothoracic Surgery1749-80902012-09-01718110.1186/1749-8090-7-81Daptomycin as supportive treatment option in patients developing mediastinitis after open cardiac surgeryWeis FlorianHeyn JensHinske Christian LVogt FerdinandWeis MarionKur FelixHagl ChristianBeiras-Fernandez Andres<p>Abstract</p> <p>Background</p> <p>Mediastinitis is a severe complication after cardiac surgery. While improvement of prophylaxis and of medical and surgical therapy has reduced its incidence, the treatment of mediastinitis continues to be a challenging problem. Within this study, we report the successful use of daptomycin as supportive therapy in patients developing mediastinitis after open cardiac surgery.</p> <p>Methods</p> <p>The records of 21 consecutive patients who developed mediastinitis after cardiac surgery were retrospectively reviewed. After diagnosis, all patients received surgical debridement and antibiotic therapy with daptomycin. All patients were followed up to death or discharge.</p> <p>Results</p> <p>Clinical improvement after combined surgical and antibiotic therapy with daptomycin was found in 90.5% of the patients. The median time until clinical improvement occurred was 5 [4/6] days. Daptomycin was well-tolerated and no major adverse events during therapy were observed observed.</p> <p>Conclusions</p> <p>This study provides new and helpful information regarding the beneficial use of daptomycin as supportive treatment option in patients developing mediastinitis after cardiac surgery.</p>http://www.cardiothoracicsurgery.org/content/7/1/81MediastinitisCardiac surgeryDaptomycin |
| spellingShingle | Weis Florian Heyn Jens Hinske Christian L Vogt Ferdinand Weis Marion Kur Felix Hagl Christian Beiras-Fernandez Andres Daptomycin as supportive treatment option in patients developing mediastinitis after open cardiac surgery Journal of Cardiothoracic Surgery Mediastinitis Cardiac surgery Daptomycin |
| title | Daptomycin as supportive treatment option in patients developing mediastinitis after open cardiac surgery |
| title_full | Daptomycin as supportive treatment option in patients developing mediastinitis after open cardiac surgery |
| title_fullStr | Daptomycin as supportive treatment option in patients developing mediastinitis after open cardiac surgery |
| title_full_unstemmed | Daptomycin as supportive treatment option in patients developing mediastinitis after open cardiac surgery |
| title_short | Daptomycin as supportive treatment option in patients developing mediastinitis after open cardiac surgery |
| title_sort | daptomycin as supportive treatment option in patients developing mediastinitis after open cardiac surgery |
| topic | Mediastinitis Cardiac surgery Daptomycin |
| url | http://www.cardiothoracicsurgery.org/content/7/1/81 |
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