| Summary: | The synthesis of three alkoxy alcohols with different chains was carried out from eugenol oxirane. These derivatives were evaluated against their effect on the viability of the insect cell line <i>Sf9</i> (<i>Spodoptera frugiperda</i>). The molecules under study displayed mild-cytotoxic activity towards insect cells, equivalent to the commercial insecticide chlorpyrifos. Nanoencapsulation studies of the most active compound against <i>Sf9</i> were performed using liposomes of egg-phosphatidylcholine containing 30% cholesterol. The encapsulation efficiency is around 93%, and the release profile for 24 h follows a Korsmeyer–Peppas model.
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