VARIETY OF COMBINATIONS OF HASHIMOTO’S THYROIDITIS WITH OTHER BACKGROUND PATHOLOGY OF THYROID PARENCHEMA IN DIFFERENT FORMS OF THYROID CANCER
Aim. The aim of this study was to evaluate the frequency of combinations of Hashimoto’s thyroiditis (HT) with other underlying pathology of the thyroid parenchyma in various forms of thyroid cancer (TC). Patients and methods. This was a retrospective study of 424 histological preparations of patient...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ukrainian Medical Stomatological Academy
2020-09-01
|
| Series: | Вісник проблем біології і медицини |
| Subjects: | |
| Online Access: | https://vpbm.com.ua/upload/2020-3(157)/25-min.pdf |
| _version_ | 1819155713086193664 |
|---|---|
| author | Karachentsev Yu. I. Dubovik V. M. Gopkalova I. V. Khaziev V. V. Sokolova S. S. Korchagin Y. P. Filonenko N. G. Sazonov M. Y. Gerasimenko L. V. |
| author_facet | Karachentsev Yu. I. Dubovik V. M. Gopkalova I. V. Khaziev V. V. Sokolova S. S. Korchagin Y. P. Filonenko N. G. Sazonov M. Y. Gerasimenko L. V. |
| author_sort | Karachentsev Yu. I. |
| collection | DOAJ |
| description | Aim. The aim of this study was to evaluate the frequency of combinations of Hashimoto’s thyroiditis (HT) with other underlying pathology of the thyroid parenchyma in various forms of thyroid cancer (TC). Patients and methods. This was a retrospective study of 424 histological preparations of patients with TC who had undergone thyroidectomy over an 12-year period (between 2008 and 2019). Was determined of morphological variant of the TС, which appeared of combinations of HT with and without other pathology of the thyroid parenchyma. All statistical calculations are made using Statistics 6.0 Copyright © StatSoft, Inc. 1984-2001, Serial number 31415926535897. Statistical analysis was performed using chi-square test and Fisher’s exact criterion. Results. It was shown that thyroid cancer, as an independent disease, occurred in 35.8% of ТС (152 cases). However, it was found that Gyurtle- cellular ТС, as an independent disease, on the background of intact thyroid parenchyma was observed significantly less often (РF 2-4 = 0,04; РF 3-4 = 0,021), than follicular ТС and medullary ТС, and papillary ТС – much less common than follicular ТС (Рχ1-2 = 0,003). HT as a background pathology, in a separate form was detected in 58 cases (13.7%) of the ТС, and in combination with other pathology of the thyroid gland in 67 cases (15.8%). Thus, in general, HT is 29.5% (125 cases), the last 147 cases of the thyroid gland were combined with other background pathology of the thyroid gland. The most common background thyroid diseases at which ТС was detected in combination with НТ were colloid goiter and follicular adenoma, as well as their combinations. In total, НТ was found in papillary ТС in 47% of cases, in medullary ТС – in 30%, in Gyurtle- cellular – in 56% and in poorly differentiated ТС – in 40%. It was shown, that in combination with follicular carcinoma, НT is detected significantly less frequently than in all other studied forms of ТC (in pure form – 2.5%, all in all – 5.5%). Conclusions. Such a frequent combination of thyroid cancer with other thyroid diseases can significantly complicate preoperative diagnosis and requires special attention when choosing treatment tactics. |
| first_indexed | 2024-12-22T15:41:21Z |
| format | Article |
| id | doaj.art-365f386c99b649ebb719423cfab22aba |
| institution | Directory Open Access Journal |
| issn | 2077-4214 2523-4110 |
| language | English |
| last_indexed | 2024-12-22T15:41:21Z |
| publishDate | 2020-09-01 |
| publisher | Ukrainian Medical Stomatological Academy |
| record_format | Article |
| series | Вісник проблем біології і медицини |
| spelling | doaj.art-365f386c99b649ebb719423cfab22aba2022-12-21T18:21:07ZengUkrainian Medical Stomatological AcademyВісник проблем біології і медицини2077-42142523-41102020-09-01310510910.29254/2077-4214-2020-3-157-105-1092077-4214-2020-3-157-105-109VARIETY OF COMBINATIONS OF HASHIMOTO’S THYROIDITIS WITH OTHER BACKGROUND PATHOLOGY OF THYROID PARENCHEMA IN DIFFERENT FORMS OF THYROID CANCERKarachentsev Yu. I.0Dubovik V. M.1Gopkalova I. V.2Khaziev V. V.3Sokolova S. S.4Korchagin Y. P.5Filonenko N. G.6Sazonov M. Y.7Gerasimenko L. V.8 Institute problem endocrine pathology of V.Ya. Danilevskiy NAMS Ukraine Institute problem endocrine pathology of V.Ya. Danilevskiy NAMS Ukraine Institute problem endocrine pathology of V.Ya. Danilevskiy NAMS Ukraine Institute problem endocrine pathology of V.Ya. Danilevskiy NAMS Ukraine Institute problem endocrine pathology of V.Ya. Danilevskiy NAMS Ukraine Institute problem endocrine pathology of V.Ya. Danilevskiy NAMS Ukraine Institute problem endocrine pathology of V.Ya. Danilevskiy NAMS Ukraine Institute problem endocrine pathology of V.Ya. Danilevskiy NAMS Ukraine Institute problem endocrine pathology of V.Ya. Danilevskiy NAMS Ukraine Aim. The aim of this study was to evaluate the frequency of combinations of Hashimoto’s thyroiditis (HT) with other underlying pathology of the thyroid parenchyma in various forms of thyroid cancer (TC). Patients and methods. This was a retrospective study of 424 histological preparations of patients with TC who had undergone thyroidectomy over an 12-year period (between 2008 and 2019). Was determined of morphological variant of the TС, which appeared of combinations of HT with and without other pathology of the thyroid parenchyma. All statistical calculations are made using Statistics 6.0 Copyright © StatSoft, Inc. 1984-2001, Serial number 31415926535897. Statistical analysis was performed using chi-square test and Fisher’s exact criterion. Results. It was shown that thyroid cancer, as an independent disease, occurred in 35.8% of ТС (152 cases). However, it was found that Gyurtle- cellular ТС, as an independent disease, on the background of intact thyroid parenchyma was observed significantly less often (РF 2-4 = 0,04; РF 3-4 = 0,021), than follicular ТС and medullary ТС, and papillary ТС – much less common than follicular ТС (Рχ1-2 = 0,003). HT as a background pathology, in a separate form was detected in 58 cases (13.7%) of the ТС, and in combination with other pathology of the thyroid gland in 67 cases (15.8%). Thus, in general, HT is 29.5% (125 cases), the last 147 cases of the thyroid gland were combined with other background pathology of the thyroid gland. The most common background thyroid diseases at which ТС was detected in combination with НТ were colloid goiter and follicular adenoma, as well as their combinations. In total, НТ was found in papillary ТС in 47% of cases, in medullary ТС – in 30%, in Gyurtle- cellular – in 56% and in poorly differentiated ТС – in 40%. It was shown, that in combination with follicular carcinoma, НT is detected significantly less frequently than in all other studied forms of ТC (in pure form – 2.5%, all in all – 5.5%). Conclusions. Such a frequent combination of thyroid cancer with other thyroid diseases can significantly complicate preoperative diagnosis and requires special attention when choosing treatment tactics. https://vpbm.com.ua/upload/2020-3(157)/25-min.pdf thyroid glandthyroid cancerautoimmune thyroiditiscolloid goiterfollicular adenoma. |
| spellingShingle | Karachentsev Yu. I. Dubovik V. M. Gopkalova I. V. Khaziev V. V. Sokolova S. S. Korchagin Y. P. Filonenko N. G. Sazonov M. Y. Gerasimenko L. V. VARIETY OF COMBINATIONS OF HASHIMOTO’S THYROIDITIS WITH OTHER BACKGROUND PATHOLOGY OF THYROID PARENCHEMA IN DIFFERENT FORMS OF THYROID CANCER Вісник проблем біології і медицини thyroid gland thyroid cancer autoimmune thyroiditis colloid goiter follicular adenoma. |
| title | VARIETY OF COMBINATIONS OF HASHIMOTO’S THYROIDITIS WITH OTHER BACKGROUND PATHOLOGY OF THYROID PARENCHEMA IN DIFFERENT FORMS OF THYROID CANCER |
| title_full | VARIETY OF COMBINATIONS OF HASHIMOTO’S THYROIDITIS WITH OTHER BACKGROUND PATHOLOGY OF THYROID PARENCHEMA IN DIFFERENT FORMS OF THYROID CANCER |
| title_fullStr | VARIETY OF COMBINATIONS OF HASHIMOTO’S THYROIDITIS WITH OTHER BACKGROUND PATHOLOGY OF THYROID PARENCHEMA IN DIFFERENT FORMS OF THYROID CANCER |
| title_full_unstemmed | VARIETY OF COMBINATIONS OF HASHIMOTO’S THYROIDITIS WITH OTHER BACKGROUND PATHOLOGY OF THYROID PARENCHEMA IN DIFFERENT FORMS OF THYROID CANCER |
| title_short | VARIETY OF COMBINATIONS OF HASHIMOTO’S THYROIDITIS WITH OTHER BACKGROUND PATHOLOGY OF THYROID PARENCHEMA IN DIFFERENT FORMS OF THYROID CANCER |
| title_sort | variety of combinations of hashimoto s thyroiditis with other background pathology of thyroid parenchema in different forms of thyroid cancer |
| topic | thyroid gland thyroid cancer autoimmune thyroiditis colloid goiter follicular adenoma. |
| url | https://vpbm.com.ua/upload/2020-3(157)/25-min.pdf |
| work_keys_str_mv | AT karachentsevyui varietyofcombinationsofhashimotosthyroiditiswithotherbackgroundpathologyofthyroidparenchemaindifferentformsofthyroidcancer AT dubovikvm varietyofcombinationsofhashimotosthyroiditiswithotherbackgroundpathologyofthyroidparenchemaindifferentformsofthyroidcancer AT gopkalovaiv varietyofcombinationsofhashimotosthyroiditiswithotherbackgroundpathologyofthyroidparenchemaindifferentformsofthyroidcancer AT khazievvv varietyofcombinationsofhashimotosthyroiditiswithotherbackgroundpathologyofthyroidparenchemaindifferentformsofthyroidcancer AT sokolovass varietyofcombinationsofhashimotosthyroiditiswithotherbackgroundpathologyofthyroidparenchemaindifferentformsofthyroidcancer AT korchaginyp varietyofcombinationsofhashimotosthyroiditiswithotherbackgroundpathologyofthyroidparenchemaindifferentformsofthyroidcancer AT filonenkong varietyofcombinationsofhashimotosthyroiditiswithotherbackgroundpathologyofthyroidparenchemaindifferentformsofthyroidcancer AT sazonovmy varietyofcombinationsofhashimotosthyroiditiswithotherbackgroundpathologyofthyroidparenchemaindifferentformsofthyroidcancer AT gerasimenkolv varietyofcombinationsofhashimotosthyroiditiswithotherbackgroundpathologyofthyroidparenchemaindifferentformsofthyroidcancer |