Endoscopic Complications Are More Frequent in Levodopa–Carbidopa Intestinal Gel Treatment via JET-PEG in Parkinson’s Disease Patients Compared to Nutritional PEG in Non-Parkinson’s Disease Patients
<b>Background</b>: To date, no studies comparing complication rates between patients with nutritional percutaneous endoscopic gastrostomy (N-PEG) and Parkinson’s disease (PD) patients with percutaneous endoscopic gastro-jejunostomy (JET-PEG) for treatment administration have been publish...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/3/703 |
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| author | Laura Gombošová Jana Deptová Ivana Jochmanová Tatiana Svoreňová Eduard Veseliny Mária Zakuciová Vladimír Haň Alexandra Lacková Kristína Kulcsárová Miriama Ostrožovičová Joaquim Ribeiro Ventosa Lenka Trcková Ivica Lazúrová Matej Škorvánek |
| author_facet | Laura Gombošová Jana Deptová Ivana Jochmanová Tatiana Svoreňová Eduard Veseliny Mária Zakuciová Vladimír Haň Alexandra Lacková Kristína Kulcsárová Miriama Ostrožovičová Joaquim Ribeiro Ventosa Lenka Trcková Ivica Lazúrová Matej Škorvánek |
| author_sort | Laura Gombošová |
| collection | DOAJ |
| description | <b>Background</b>: To date, no studies comparing complication rates between patients with nutritional percutaneous endoscopic gastrostomy (N-PEG) and Parkinson’s disease (PD) patients with percutaneous endoscopic gastro-jejunostomy (JET-PEG) for treatment administration have been published. Our study aimed to compare complication rates and the number of re-endoscopies between N-PEG and JET-PEG patients. <b>Methods</b>: Individuals requiring N-PEG or JET-PEG insertion between 2014 and 2021 were included in this single-center retrospective observational study. Complications were divided into time-related medical and technical complications. Reasons for post-insertion re-endoscopies and their number were also analyzed. <b>Results</b>: Eighty-seven subjects, 47 (54.02%) in JET-PEG group and 40 (45.98%) in the N-PEG group, were included. Early and technical complications were more frequent in JET-PEG vs. N-PEG subjects (70% vs. 10% [<i>p</i> < 0.001], and 54.5% vs. 5.1% [<i>p</i> < 0.001], respectively). The presence of psychiatric disease was associated with a higher number of early complications (<i>p</i> < 0.002). All three types of complications were significantly more frequent in subjects where a healthcare professional did not handle PEG (<i>p</i> < 0.001). Subjects with JET-PEG required a higher number of re-endoscopies compared to the N-PEG group (57.1% vs. 35%, <i>p</i> = 0.05). <b>Conclusions</b>: Complications are significantly more common in individuals with JET-PEG than those with N-PEG, which can be attributed to higher mobility in PD patients. |
| first_indexed | 2024-03-08T03:54:26Z |
| format | Article |
| id | doaj.art-36609f8e36864b03af18e82feeb100f5 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T03:54:26Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-36609f8e36864b03af18e82feeb100f52024-02-09T15:15:38ZengMDPI AGJournal of Clinical Medicine2077-03832024-01-0113370310.3390/jcm13030703Endoscopic Complications Are More Frequent in Levodopa–Carbidopa Intestinal Gel Treatment via JET-PEG in Parkinson’s Disease Patients Compared to Nutritional PEG in Non-Parkinson’s Disease PatientsLaura Gombošová0Jana Deptová1Ivana Jochmanová2Tatiana Svoreňová3Eduard Veseliny4Mária Zakuciová5Vladimír Haň6Alexandra Lacková7Kristína Kulcsárová8Miriama Ostrožovičová9Joaquim Ribeiro Ventosa10Lenka Trcková11Ivica Lazúrová12Matej Škorvánek132nd Department of Internal Medicine, Faculty of Medicine, University Hospital of Louis Pasteur, Pavol Jozef Šafárik University, 04001 Košice, Slovakia1st Department of Internal Medicine, Faculty of Medicine, University Hospital of Louis Pasteur, Pavol Jozef Šafárik University, 04001 Košice, Slovakia1st Department of Internal Medicine, Faculty of Medicine, University Hospital of Louis Pasteur, Pavol Jozef Šafárik University, 04001 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 04001 Košice, Slovakia2nd Department of Internal Medicine, Faculty of Medicine, University Hospital of Louis Pasteur, Pavol Jozef Šafárik University, 04001 Košice, Slovakia2nd Department of Internal Medicine, Faculty of Medicine, University Hospital of Louis Pasteur, Pavol Jozef Šafárik University, 04001 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 04001 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 04001 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 04001 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 04001 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 04001 Košice, SlovakiaDepartment of Neurology, University Hospital of Louis Pasteur, 04001 Košice, Slovakia1st Department of Internal Medicine, Faculty of Medicine, University Hospital of Louis Pasteur, Pavol Jozef Šafárik University, 04001 Košice, SlovakiaDepartment of Neurology, Faculty of Medicine, Pavol Jozef Šafárik University, 04001 Košice, Slovakia<b>Background</b>: To date, no studies comparing complication rates between patients with nutritional percutaneous endoscopic gastrostomy (N-PEG) and Parkinson’s disease (PD) patients with percutaneous endoscopic gastro-jejunostomy (JET-PEG) for treatment administration have been published. Our study aimed to compare complication rates and the number of re-endoscopies between N-PEG and JET-PEG patients. <b>Methods</b>: Individuals requiring N-PEG or JET-PEG insertion between 2014 and 2021 were included in this single-center retrospective observational study. Complications were divided into time-related medical and technical complications. Reasons for post-insertion re-endoscopies and their number were also analyzed. <b>Results</b>: Eighty-seven subjects, 47 (54.02%) in JET-PEG group and 40 (45.98%) in the N-PEG group, were included. Early and technical complications were more frequent in JET-PEG vs. N-PEG subjects (70% vs. 10% [<i>p</i> < 0.001], and 54.5% vs. 5.1% [<i>p</i> < 0.001], respectively). The presence of psychiatric disease was associated with a higher number of early complications (<i>p</i> < 0.002). All three types of complications were significantly more frequent in subjects where a healthcare professional did not handle PEG (<i>p</i> < 0.001). Subjects with JET-PEG required a higher number of re-endoscopies compared to the N-PEG group (57.1% vs. 35%, <i>p</i> = 0.05). <b>Conclusions</b>: Complications are significantly more common in individuals with JET-PEG than those with N-PEG, which can be attributed to higher mobility in PD patients.https://www.mdpi.com/2077-0383/13/3/703percutaneous endoscopic gastrostomy (PEG)levodopa–carbidopa intestinal gel therapyadvanced Parkinson’s diseasecomplications |
| spellingShingle | Laura Gombošová Jana Deptová Ivana Jochmanová Tatiana Svoreňová Eduard Veseliny Mária Zakuciová Vladimír Haň Alexandra Lacková Kristína Kulcsárová Miriama Ostrožovičová Joaquim Ribeiro Ventosa Lenka Trcková Ivica Lazúrová Matej Škorvánek Endoscopic Complications Are More Frequent in Levodopa–Carbidopa Intestinal Gel Treatment via JET-PEG in Parkinson’s Disease Patients Compared to Nutritional PEG in Non-Parkinson’s Disease Patients Journal of Clinical Medicine percutaneous endoscopic gastrostomy (PEG) levodopa–carbidopa intestinal gel therapy advanced Parkinson’s disease complications |
| title | Endoscopic Complications Are More Frequent in Levodopa–Carbidopa Intestinal Gel Treatment via JET-PEG in Parkinson’s Disease Patients Compared to Nutritional PEG in Non-Parkinson’s Disease Patients |
| title_full | Endoscopic Complications Are More Frequent in Levodopa–Carbidopa Intestinal Gel Treatment via JET-PEG in Parkinson’s Disease Patients Compared to Nutritional PEG in Non-Parkinson’s Disease Patients |
| title_fullStr | Endoscopic Complications Are More Frequent in Levodopa–Carbidopa Intestinal Gel Treatment via JET-PEG in Parkinson’s Disease Patients Compared to Nutritional PEG in Non-Parkinson’s Disease Patients |
| title_full_unstemmed | Endoscopic Complications Are More Frequent in Levodopa–Carbidopa Intestinal Gel Treatment via JET-PEG in Parkinson’s Disease Patients Compared to Nutritional PEG in Non-Parkinson’s Disease Patients |
| title_short | Endoscopic Complications Are More Frequent in Levodopa–Carbidopa Intestinal Gel Treatment via JET-PEG in Parkinson’s Disease Patients Compared to Nutritional PEG in Non-Parkinson’s Disease Patients |
| title_sort | endoscopic complications are more frequent in levodopa carbidopa intestinal gel treatment via jet peg in parkinson s disease patients compared to nutritional peg in non parkinson s disease patients |
| topic | percutaneous endoscopic gastrostomy (PEG) levodopa–carbidopa intestinal gel therapy advanced Parkinson’s disease complications |
| url | https://www.mdpi.com/2077-0383/13/3/703 |
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