Advances of NLRP3 Inflammasome in Post-stroke Cognitive Impairment
A common complication of stroke patients is post-stroke cognitive impairment (PSCI) , which significantly reduces their quality of life. There are no effective targeted treatment measures currently available for PSCI in clinical practice. A large number of studies have already indicated that the act...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2023-06-01
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| Series: | Zhongguo quanke yixue |
| Subjects: | |
| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220609.pdf |
| _version_ | 1827289459530399744 |
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| author | LI Xiaoxiao, BAI Yanjie, WANG Yan, ZHANG Yongchuang, CHEN Shuying, CHEN Limin |
| author_facet | LI Xiaoxiao, BAI Yanjie, WANG Yan, ZHANG Yongchuang, CHEN Shuying, CHEN Limin |
| author_sort | LI Xiaoxiao, BAI Yanjie, WANG Yan, ZHANG Yongchuang, CHEN Shuying, CHEN Limin |
| collection | DOAJ |
| description | A common complication of stroke patients is post-stroke cognitive impairment (PSCI) , which significantly reduces their quality of life. There are no effective targeted treatment measures currently available for PSCI in clinical practice. A large number of studies have already indicated that the activation of NLRP3 inflammasome plays a crucial role in PSCI, and many inhibitory treatments have been shown to improve cognitive impairment. The purpose of this study was to summarized the activation and modulating factors of NLRP3 inflammatory bodies and the relationship with PSCI. Some studies have been demonstrated that inhibiting NLRP3 or its associated inflammatory body components reduces the inflammatory response, promoting cognitive function recovery in cell and animal models of PSCI. Consequently, targeting NLRP3 inflammatory bodies may be a new trends of dealing with PSCI treatment. Despite the fact that numerous drugs and therapeutic measures have been proved to suppress the activation of NLRP3 inflammatory bodies, their clinical efficacy and safety have not yet been confirmed. |
| first_indexed | 2024-04-24T11:49:55Z |
| format | Article |
| id | doaj.art-3661944ca9494adfb9b866999661a117 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:49:55Z |
| publishDate | 2023-06-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-3661944ca9494adfb9b866999661a1172024-04-09T08:03:56ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722023-06-0126172176218210.12114/j.issn.1007-9572.2022.0609Advances of NLRP3 Inflammasome in Post-stroke Cognitive ImpairmentLI Xiaoxiao, BAI Yanjie, WANG Yan, ZHANG Yongchuang, CHEN Shuying, CHEN Limin01. Henan University of Chinese Medicine, Zhengzhou 450046, China;2. The First Affiliated Hospital of Henan University of CM, Zhengzhou 450000, ChinaA common complication of stroke patients is post-stroke cognitive impairment (PSCI) , which significantly reduces their quality of life. There are no effective targeted treatment measures currently available for PSCI in clinical practice. A large number of studies have already indicated that the activation of NLRP3 inflammasome plays a crucial role in PSCI, and many inhibitory treatments have been shown to improve cognitive impairment. The purpose of this study was to summarized the activation and modulating factors of NLRP3 inflammatory bodies and the relationship with PSCI. Some studies have been demonstrated that inhibiting NLRP3 or its associated inflammatory body components reduces the inflammatory response, promoting cognitive function recovery in cell and animal models of PSCI. Consequently, targeting NLRP3 inflammatory bodies may be a new trends of dealing with PSCI treatment. Despite the fact that numerous drugs and therapeutic measures have been proved to suppress the activation of NLRP3 inflammatory bodies, their clinical efficacy and safety have not yet been confirmed.https://www.chinagp.net/fileup/1007-9572/PDF/zx20220609.pdfcognition disorders|stroke|post-stroke cognitive impairment|nlrp3 inflammasome|neuroinflammation|mitochondrial dysfunction|review |
| spellingShingle | LI Xiaoxiao, BAI Yanjie, WANG Yan, ZHANG Yongchuang, CHEN Shuying, CHEN Limin Advances of NLRP3 Inflammasome in Post-stroke Cognitive Impairment Zhongguo quanke yixue cognition disorders|stroke|post-stroke cognitive impairment|nlrp3 inflammasome|neuroinflammation|mitochondrial dysfunction|review |
| title | Advances of NLRP3 Inflammasome in Post-stroke Cognitive Impairment |
| title_full | Advances of NLRP3 Inflammasome in Post-stroke Cognitive Impairment |
| title_fullStr | Advances of NLRP3 Inflammasome in Post-stroke Cognitive Impairment |
| title_full_unstemmed | Advances of NLRP3 Inflammasome in Post-stroke Cognitive Impairment |
| title_short | Advances of NLRP3 Inflammasome in Post-stroke Cognitive Impairment |
| title_sort | advances of nlrp3 inflammasome in post stroke cognitive impairment |
| topic | cognition disorders|stroke|post-stroke cognitive impairment|nlrp3 inflammasome|neuroinflammation|mitochondrial dysfunction|review |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/zx20220609.pdf |
| work_keys_str_mv | AT lixiaoxiaobaiyanjiewangyanzhangyongchuangchenshuyingchenlimin advancesofnlrp3inflammasomeinpoststrokecognitiveimpairment |