Predictors of Long-Term Survival of Thoracoscopic Lobectomy for Stage IA Non-Small Cell Lung Cancer: A Large Retrospective Cohort Study
The standard of care for patients with early-stage non-small cell lung cancer (NSCLC) is anatomical lung resection with lymphadenectomy. This multicenter, retrospective, cohort study aimed to identify predictors of 5-year survival in patients after thoracoscopic lobectomy for stage IA NSCLC. The stu...
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MDPI AG
2023-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/15/3877 |
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| author | Piotr Gabryel Piotr Skrzypczak Alessio Campisi Mariusz Kasprzyk Magdalena Roszak Cezary Piwkowski |
| author_facet | Piotr Gabryel Piotr Skrzypczak Alessio Campisi Mariusz Kasprzyk Magdalena Roszak Cezary Piwkowski |
| author_sort | Piotr Gabryel |
| collection | DOAJ |
| description | The standard of care for patients with early-stage non-small cell lung cancer (NSCLC) is anatomical lung resection with lymphadenectomy. This multicenter, retrospective, cohort study aimed to identify predictors of 5-year survival in patients after thoracoscopic lobectomy for stage IA NSCLC. The study included 1249 patients who underwent thoracoscopic lobectomy for stage IA NSCLC between 17 April 2007, and December 28, 2016. The 5-year survival rate equaled 77.7%. In the multivariate analysis, higher age (OR, 1.025, 95% CI: 1.002 to 1.048; <i>p</i> = 0.032), male sex (OR, 1.410, 95% CI: 1.109 to 1.793; <i>p</i> = 0.005), chronic obstructive pulmonary disease (OR, 1.346, 95% CI: 1.005 to 1.803; <i>p</i> = 0.046), prolonged postoperative air leak (OR, 2.060, 95% CI: 1.424 to 2.980; <i>p</i> < 0.001) and higher pathological stage (OR, 1.271, 95% CI: 1.048 to 1.541; <i>p</i> = 0.015) were related to the increased risk of death within 5 years after surgery. Lobe-specific mediastinal lymph node dissection (OR, 0.725, 95% CI: 0.548 to 0.959; <i>p</i> = 0.024) was related to the decreased risk of death within 5 years after surgery. These findings provide valuable insights for clinical practice and may contribute to improving the quality of treatment of early-stage NSCLC. |
| first_indexed | 2024-03-11T00:30:09Z |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T00:30:09Z |
| publishDate | 2023-07-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3662755e98ed4396a6baa67a79f533472023-11-18T22:42:37ZengMDPI AGCancers2072-66942023-07-011515387710.3390/cancers15153877Predictors of Long-Term Survival of Thoracoscopic Lobectomy for Stage IA Non-Small Cell Lung Cancer: A Large Retrospective Cohort StudyPiotr Gabryel0Piotr Skrzypczak1Alessio Campisi2Mariusz Kasprzyk3Magdalena Roszak4Cezary Piwkowski5Department of Thoracic Surgery, Poznan University of Medical Sciences, Szamarzewskiego 62 Street, 60-569 Poznan, PolandDepartment of Thoracic Surgery, Poznan University of Medical Sciences, Szamarzewskiego 62 Street, 60-569 Poznan, PolandDepartment of Thoracic Surgery, University and Hospital Trust—Ospedale Borgo Trento, Piazzale Aristide Stefani 1, 37126 Verona, ItalyDepartment of Thoracic Surgery, Poznan University of Medical Sciences, Szamarzewskiego 62 Street, 60-569 Poznan, PolandDepartment of Computer Science and Statistics, Poznan University of Medical Sciences, Rokietnicka 7 Street, 60-806 Poznan, PolandDepartment of Thoracic Surgery, Poznan University of Medical Sciences, Szamarzewskiego 62 Street, 60-569 Poznan, PolandThe standard of care for patients with early-stage non-small cell lung cancer (NSCLC) is anatomical lung resection with lymphadenectomy. This multicenter, retrospective, cohort study aimed to identify predictors of 5-year survival in patients after thoracoscopic lobectomy for stage IA NSCLC. The study included 1249 patients who underwent thoracoscopic lobectomy for stage IA NSCLC between 17 April 2007, and December 28, 2016. The 5-year survival rate equaled 77.7%. In the multivariate analysis, higher age (OR, 1.025, 95% CI: 1.002 to 1.048; <i>p</i> = 0.032), male sex (OR, 1.410, 95% CI: 1.109 to 1.793; <i>p</i> = 0.005), chronic obstructive pulmonary disease (OR, 1.346, 95% CI: 1.005 to 1.803; <i>p</i> = 0.046), prolonged postoperative air leak (OR, 2.060, 95% CI: 1.424 to 2.980; <i>p</i> < 0.001) and higher pathological stage (OR, 1.271, 95% CI: 1.048 to 1.541; <i>p</i> = 0.015) were related to the increased risk of death within 5 years after surgery. Lobe-specific mediastinal lymph node dissection (OR, 0.725, 95% CI: 0.548 to 0.959; <i>p</i> = 0.024) was related to the decreased risk of death within 5 years after surgery. These findings provide valuable insights for clinical practice and may contribute to improving the quality of treatment of early-stage NSCLC.https://www.mdpi.com/2072-6694/15/15/3877lung cancersurgerythoracoscopyVATSminimally invasive surgerylobectomy |
| spellingShingle | Piotr Gabryel Piotr Skrzypczak Alessio Campisi Mariusz Kasprzyk Magdalena Roszak Cezary Piwkowski Predictors of Long-Term Survival of Thoracoscopic Lobectomy for Stage IA Non-Small Cell Lung Cancer: A Large Retrospective Cohort Study Cancers lung cancer surgery thoracoscopy VATS minimally invasive surgery lobectomy |
| title | Predictors of Long-Term Survival of Thoracoscopic Lobectomy for Stage IA Non-Small Cell Lung Cancer: A Large Retrospective Cohort Study |
| title_full | Predictors of Long-Term Survival of Thoracoscopic Lobectomy for Stage IA Non-Small Cell Lung Cancer: A Large Retrospective Cohort Study |
| title_fullStr | Predictors of Long-Term Survival of Thoracoscopic Lobectomy for Stage IA Non-Small Cell Lung Cancer: A Large Retrospective Cohort Study |
| title_full_unstemmed | Predictors of Long-Term Survival of Thoracoscopic Lobectomy for Stage IA Non-Small Cell Lung Cancer: A Large Retrospective Cohort Study |
| title_short | Predictors of Long-Term Survival of Thoracoscopic Lobectomy for Stage IA Non-Small Cell Lung Cancer: A Large Retrospective Cohort Study |
| title_sort | predictors of long term survival of thoracoscopic lobectomy for stage ia non small cell lung cancer a large retrospective cohort study |
| topic | lung cancer surgery thoracoscopy VATS minimally invasive surgery lobectomy |
| url | https://www.mdpi.com/2072-6694/15/15/3877 |
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