Immuno-antioxidative reno-modulatory effectiveness of Echinacea purpurea extract against bifenthrin-induced renal poisoning
Abstract This study was conducted to evaluate the ameliorative, anti-inflammatory, antioxidant, and chemical detoxifying activities of Echinacea purpurea ethanolic extract (EEE) against bifenthrin-induced renal injury. Adult male albino rats (160–200 g) were divided into four groups (10 rats each) a...
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| Format: | Article |
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-56494-4 |
| _version_ | 1797259340076285952 |
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| author | Khaled G. Abdel-Wahhab Ghada M. Elqattan Doaa G. EL-Sahra Laila K. Hassan Rehab S. Sayed Fathia A. Mannaa |
| author_facet | Khaled G. Abdel-Wahhab Ghada M. Elqattan Doaa G. EL-Sahra Laila K. Hassan Rehab S. Sayed Fathia A. Mannaa |
| author_sort | Khaled G. Abdel-Wahhab |
| collection | DOAJ |
| description | Abstract This study was conducted to evaluate the ameliorative, anti-inflammatory, antioxidant, and chemical detoxifying activities of Echinacea purpurea ethanolic extract (EEE) against bifenthrin-induced renal injury. Adult male albino rats (160–200 g) were divided into four groups (10 rats each) and orally treated for 30 days as follows: (1) normal control; (2) healthy animals were treated with EEE (465 mg/kg/day) dissolved in water; (3) healthy animals were given bifenthrin (7 mg/kg/day) dissolved in olive oil; (4) animals were orally administered with EEE 1-h prior bifenthrin intoxication. The obtained results revealed that administration of the animals with bifenthrin caused significant elevations of serum values of urea, creatinine, ALAT and ASAT, as well as renal inflammatory (IL-1β, TNF-α & IFN-γ), apoptotic (Caspase-3) and oxidative stress (MDA and NO) markers coupled with a marked drop in the values of renal antioxidant markers (GSH, GPx, and SOD) in compare to those of normal control. Administration of EEE prior to bifenthrin resulted in a considerable amelioration of the mentioned deteriorated parameters near to that of control; moreover, the extract markedly improved the histological architecture of the kidney. In conclusion, Echinacea purpurea ethanolic extract has promising ameliorative, antioxidant, anti-inflammatory, renoprotective, and detoxifying efficiencies against bifenthrin-induced renal injury. |
| first_indexed | 2024-04-24T23:07:52Z |
| format | Article |
| id | doaj.art-366393df61df43958a0194cec409684e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-24T23:07:52Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-366393df61df43958a0194cec409684e2024-03-17T12:23:51ZengNature PortfolioScientific Reports2045-23222024-03-0114111210.1038/s41598-024-56494-4Immuno-antioxidative reno-modulatory effectiveness of Echinacea purpurea extract against bifenthrin-induced renal poisoningKhaled G. Abdel-Wahhab0Ghada M. Elqattan1Doaa G. EL-Sahra2Laila K. Hassan3Rehab S. Sayed4Fathia A. Mannaa5Medical Physiology Department, National Research CentreMedical Physiology Department, National Research CentreModern University for Technology and InformationDairy Department, National Research CentreRegional Center for Food and Feed, Agriculture Research CentreMedical Physiology Department, National Research CentreAbstract This study was conducted to evaluate the ameliorative, anti-inflammatory, antioxidant, and chemical detoxifying activities of Echinacea purpurea ethanolic extract (EEE) against bifenthrin-induced renal injury. Adult male albino rats (160–200 g) were divided into four groups (10 rats each) and orally treated for 30 days as follows: (1) normal control; (2) healthy animals were treated with EEE (465 mg/kg/day) dissolved in water; (3) healthy animals were given bifenthrin (7 mg/kg/day) dissolved in olive oil; (4) animals were orally administered with EEE 1-h prior bifenthrin intoxication. The obtained results revealed that administration of the animals with bifenthrin caused significant elevations of serum values of urea, creatinine, ALAT and ASAT, as well as renal inflammatory (IL-1β, TNF-α & IFN-γ), apoptotic (Caspase-3) and oxidative stress (MDA and NO) markers coupled with a marked drop in the values of renal antioxidant markers (GSH, GPx, and SOD) in compare to those of normal control. Administration of EEE prior to bifenthrin resulted in a considerable amelioration of the mentioned deteriorated parameters near to that of control; moreover, the extract markedly improved the histological architecture of the kidney. In conclusion, Echinacea purpurea ethanolic extract has promising ameliorative, antioxidant, anti-inflammatory, renoprotective, and detoxifying efficiencies against bifenthrin-induced renal injury.https://doi.org/10.1038/s41598-024-56494-4 |
| spellingShingle | Khaled G. Abdel-Wahhab Ghada M. Elqattan Doaa G. EL-Sahra Laila K. Hassan Rehab S. Sayed Fathia A. Mannaa Immuno-antioxidative reno-modulatory effectiveness of Echinacea purpurea extract against bifenthrin-induced renal poisoning Scientific Reports |
| title | Immuno-antioxidative reno-modulatory effectiveness of Echinacea purpurea extract against bifenthrin-induced renal poisoning |
| title_full | Immuno-antioxidative reno-modulatory effectiveness of Echinacea purpurea extract against bifenthrin-induced renal poisoning |
| title_fullStr | Immuno-antioxidative reno-modulatory effectiveness of Echinacea purpurea extract against bifenthrin-induced renal poisoning |
| title_full_unstemmed | Immuno-antioxidative reno-modulatory effectiveness of Echinacea purpurea extract against bifenthrin-induced renal poisoning |
| title_short | Immuno-antioxidative reno-modulatory effectiveness of Echinacea purpurea extract against bifenthrin-induced renal poisoning |
| title_sort | immuno antioxidative reno modulatory effectiveness of echinacea purpurea extract against bifenthrin induced renal poisoning |
| url | https://doi.org/10.1038/s41598-024-56494-4 |
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