Changes in the Resting-State Cortical Oscillatory Activity 6 Months After Modified Tinnitus Retraining Therapy
Although tinnitus retraining therapy (TRT) based on Jastreboff’s classical neurophysiological model is efficacious in most patients, its effects on the cortical activity changes responsible for the improvement of tinnitus are still unclear. In this study, we compared pre- and post-TRT resting-state...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.01123/full |
| _version_ | 1811319998695604224 |
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| author | Sang-Yeon Lee Jihye Rhee Ye Ji Shim Yoonjoong Kim Ja-Won Koo Dirk De Ridder Sven Vanneste Jae-Jin Song |
| author_facet | Sang-Yeon Lee Jihye Rhee Ye Ji Shim Yoonjoong Kim Ja-Won Koo Dirk De Ridder Sven Vanneste Jae-Jin Song |
| author_sort | Sang-Yeon Lee |
| collection | DOAJ |
| description | Although tinnitus retraining therapy (TRT) based on Jastreboff’s classical neurophysiological model is efficacious in most patients, its effects on the cortical activity changes responsible for the improvement of tinnitus are still unclear. In this study, we compared pre- and post-TRT resting-state quantitative electroencephalography (rs-qEEG) findings to identify power changes that could explain TRT-induced improvements. Thirty-seven patients with severe tinnitus were enrolled in the study, and rs-qEEG data recorded before the initial TRT sessions and 6 months after TRT were compared. In addition, associations between the changes in qEEG and percentage improvements in Tinnitus Handicap Inventory (THI) scores and numeric rating scale (NRS) scores of tinnitus loudness and tinnitus perception were examined. The mean THI score decreased significantly 6 months after the initial TRT session. Also, significant improvements were observed 6 months after the initial TRT session compared with the pre-treatment scores in NRS loudness, distress, and perception. As compared with the pre-TRT status, post-TRT 6 months status showed significantly decreased powers in the left primary and secondary auditory cortices for the gamma frequency band. Changes in the alpha 1 frequency band power in the right insula and orbitofrontal cortex (OFC) appeared to be positively correlated with the percentage changes in NRS distress. These results suggested that TRT improved tinnitus-related distress by reducing the power of the top-down autonomic response modulator or peripheral physiological responses to emotional experiences. That is, TRT induced habituation via modulation of functional connections between the auditory system and the limbic and autonomic nervous systems. Our results confer additional basis for understanding the neurophysiological model and the newly suggested integrative model of tinnitus by De Ridder et al. (2014) in the context of the long-term efficacy of TRT. |
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| format | Article |
| id | doaj.art-366ee333419d4cd99dac03b7a25240a7 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T12:51:54Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-366ee333419d4cd99dac03b7a25240a72022-12-22T02:46:10ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-10-011310.3389/fnins.2019.01123470253Changes in the Resting-State Cortical Oscillatory Activity 6 Months After Modified Tinnitus Retraining TherapySang-Yeon Lee0Jihye Rhee1Ye Ji Shim2Yoonjoong Kim3Ja-Won Koo4Dirk De Ridder5Sven Vanneste6Jae-Jin Song7Department of Otolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Otolaryngology-Head and Neck Surgery, Seoul Veterans Hospital, Seoul, South KoreaDepartment of Otolaryngology-Head & Neck Surgery, Seoul National University Hospital, Healthcare System Gangnam Center, Seoul, South KoreaDepartment of Otolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Otolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, South KoreaUnit of Neurosurgery, Department of Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New ZealandLaboratory for Clinical and Integrative Neuroscience, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, TX, United StatesDepartment of Otolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seongnam, South KoreaAlthough tinnitus retraining therapy (TRT) based on Jastreboff’s classical neurophysiological model is efficacious in most patients, its effects on the cortical activity changes responsible for the improvement of tinnitus are still unclear. In this study, we compared pre- and post-TRT resting-state quantitative electroencephalography (rs-qEEG) findings to identify power changes that could explain TRT-induced improvements. Thirty-seven patients with severe tinnitus were enrolled in the study, and rs-qEEG data recorded before the initial TRT sessions and 6 months after TRT were compared. In addition, associations between the changes in qEEG and percentage improvements in Tinnitus Handicap Inventory (THI) scores and numeric rating scale (NRS) scores of tinnitus loudness and tinnitus perception were examined. The mean THI score decreased significantly 6 months after the initial TRT session. Also, significant improvements were observed 6 months after the initial TRT session compared with the pre-treatment scores in NRS loudness, distress, and perception. As compared with the pre-TRT status, post-TRT 6 months status showed significantly decreased powers in the left primary and secondary auditory cortices for the gamma frequency band. Changes in the alpha 1 frequency band power in the right insula and orbitofrontal cortex (OFC) appeared to be positively correlated with the percentage changes in NRS distress. These results suggested that TRT improved tinnitus-related distress by reducing the power of the top-down autonomic response modulator or peripheral physiological responses to emotional experiences. That is, TRT induced habituation via modulation of functional connections between the auditory system and the limbic and autonomic nervous systems. Our results confer additional basis for understanding the neurophysiological model and the newly suggested integrative model of tinnitus by De Ridder et al. (2014) in the context of the long-term efficacy of TRT.https://www.frontiersin.org/article/10.3389/fnins.2019.01123/fulltinnitus retraining therapyquantitative electroencephalographyneurophysiological modelcortical powerconnectivity |
| spellingShingle | Sang-Yeon Lee Jihye Rhee Ye Ji Shim Yoonjoong Kim Ja-Won Koo Dirk De Ridder Sven Vanneste Jae-Jin Song Changes in the Resting-State Cortical Oscillatory Activity 6 Months After Modified Tinnitus Retraining Therapy Frontiers in Neuroscience tinnitus retraining therapy quantitative electroencephalography neurophysiological model cortical power connectivity |
| title | Changes in the Resting-State Cortical Oscillatory Activity 6 Months After Modified Tinnitus Retraining Therapy |
| title_full | Changes in the Resting-State Cortical Oscillatory Activity 6 Months After Modified Tinnitus Retraining Therapy |
| title_fullStr | Changes in the Resting-State Cortical Oscillatory Activity 6 Months After Modified Tinnitus Retraining Therapy |
| title_full_unstemmed | Changes in the Resting-State Cortical Oscillatory Activity 6 Months After Modified Tinnitus Retraining Therapy |
| title_short | Changes in the Resting-State Cortical Oscillatory Activity 6 Months After Modified Tinnitus Retraining Therapy |
| title_sort | changes in the resting state cortical oscillatory activity 6 months after modified tinnitus retraining therapy |
| topic | tinnitus retraining therapy quantitative electroencephalography neurophysiological model cortical power connectivity |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.01123/full |
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