Targeting HDAC Complexes in Asthma and COPD

Targeting HDAC Complexes in Asthma and COPD

Around three million patients die due to airway inflammatory diseases each year. The most notable of these diseases are asthma and chronic obstructive pulmonary disease (COPD). Therefore, new therapies are urgently needed. Promising targets are histone deacetylases (HDACs), since they regulate postt...

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Bibliographic Details
Main Authors: Martijn R. H. Zwinderman, Sander de Weerd, Frank J. Dekker
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Epigenomes
Subjects:
asthma
COPD
inflammation
NF-κB
HDAC
acetylation
post translational modification (PTM)
inhibitor
drug design
co-repressor complex
review
Online Access:https://www.mdpi.com/2075-4655/3/3/19

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