Metabolomic Profiling and Mechanotransduction of Single Chondrocytes Encapsulated in Alginate Microgels

Metabolomic Profiling and Mechanotransduction of Single Chondrocytes Encapsulated in Alginate Microgels

Articular cartilage is comprised of two main components, the extracellular matrix (ECM) and the pericellular matrix (PCM). The PCM helps to protect chondrocytes in the cartilage from mechanical loads, but in patients with osteoarthritis, the PCM is weakened, resulting in increased chondrocyte stress...

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Bibliographic Details
Main Authors: Jacob P. Fredrikson, Priyanka P. Brahmachary, Ayten E. Erdoğan, Zachary K. Archambault, James N. Wilking, Ronald K. June, Connie B. Chang
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
chondrocytes
microgels
microfluidics
mechanotransduction
osteoarthritis
pericellular matrix
Online Access:https://www.mdpi.com/2073-4409/11/5/900

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