Susceptibility to methamphetamine dependence associated with high transcriptional activity alleles of VNTR polymorphism in the promoter region of monoamine oxidase A (MAOA)

Susceptibility to methamphetamine dependence associated with high transcriptional activity alleles of VNTR polymorphism in the promoter region of monoamine oxidase A (MAOA)

Background and purpose: Monoamine oxidase A (MAOA, Xp11.3; OMIM: 309850) can modulate the level of neurotransmitters in the central nervous system. A 30 bp variable number of tandem repeat (VNTR) genetic polymorphism on the promoter region of the MAOA can modulate the transcriptional activity of the...

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Bibliographic Details
Main Authors: Khyber Saify, Mostafa Saadat
Format: Article
Language:English
Published: SpringerOpen 2016-01-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Methamphetamine dependence
Monoamine oxidase A
MAOA
Polymorphism
VNTR
Online Access:http://www.sciencedirect.com/science/article/pii/S1110863015000890

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