Long-term immunity induced by SPBN GASGAS in orally vaccinated dogs is non-inferior to inactivated rabies vaccines
In a long-term immunogenicity study (1100 days post vaccination) in local Thai dogs the immune response of the oral rabies vaccine SPBN GASGAS was compared to those elicited by a commercial inactivated vaccine using immunobridging. Based on the detection of rabies virus binding (rVBA) and rabies vir...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
|
| Series: | Vaccine: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590136223001511 |
| _version_ | 1797388667183955968 |
|---|---|
| author | Ad Vos Suwicha Kasemsuwan Kansuda Leelahapongsathon Katharina Bobe David Perez-Bravo Jeannette Kliemt Parinya Phawaphutayanchi Nirut Aiyara Conrad M. Freuling Thomas Müller |
| author_facet | Ad Vos Suwicha Kasemsuwan Kansuda Leelahapongsathon Katharina Bobe David Perez-Bravo Jeannette Kliemt Parinya Phawaphutayanchi Nirut Aiyara Conrad M. Freuling Thomas Müller |
| author_sort | Ad Vos |
| collection | DOAJ |
| description | In a long-term immunogenicity study (1100 days post vaccination) in local Thai dogs the immune response of the oral rabies vaccine SPBN GASGAS was compared to those elicited by a commercial inactivated vaccine using immunobridging. Based on the detection of rabies virus binding (rVBA) and rabies virus neutralizing antibodies (rVNA) as measured by ELISA and Rapid Fluorescent Focus Inhibition Test (RFFIT) the long-term immune response in dogs vaccinated orally with the SPBNA GASGAS strain of rabies vaccine in a bait was non-inferior to a conventional inactivated rabies vaccine. The outcome of this study supports extending the originally claimed duration of immunity (DOI) of SPBN GASGAS after oral vaccination for dogs from 6 to 30 months. |
| first_indexed | 2024-03-08T22:44:08Z |
| format | Article |
| id | doaj.art-3675aa216a924a4db8227007ba17f097 |
| institution | Directory Open Access Journal |
| issn | 2590-1362 |
| language | English |
| last_indexed | 2024-03-08T22:44:08Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Vaccine: X |
| spelling | doaj.art-3675aa216a924a4db8227007ba17f0972023-12-17T06:41:38ZengElsevierVaccine: X2590-13622023-12-0115100410Long-term immunity induced by SPBN GASGAS in orally vaccinated dogs is non-inferior to inactivated rabies vaccinesAd Vos0Suwicha Kasemsuwan1Kansuda Leelahapongsathon2Katharina Bobe3David Perez-Bravo4Jeannette Kliemt5Parinya Phawaphutayanchi6Nirut Aiyara7Conrad M. Freuling8Thomas Müller9Ceva Innovation Center, 06861 Dessau–Rosslau, GermanyFaculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, ThailandFaculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, ThailandCeva Innovation Center, 06861 Dessau–Rosslau, GermanyCeva Innovation Center, 06861 Dessau–Rosslau, GermanyInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut (FLI), WHO Collaborating Centre for Rabies Surveillance and Research, 17493 Greifswald-Insel Riems, GermanyDepartment of Health, Bangkok Metropolitan, Thapthan 61120, ThailandDepartment of Health, Bangkok Metropolitan, Thapthan 61120, ThailandInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut (FLI), WHO Collaborating Centre for Rabies Surveillance and Research, 17493 Greifswald-Insel Riems, GermanyInstitute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut (FLI), WHO Collaborating Centre for Rabies Surveillance and Research, 17493 Greifswald-Insel Riems, Germany; Corresponding author.In a long-term immunogenicity study (1100 days post vaccination) in local Thai dogs the immune response of the oral rabies vaccine SPBN GASGAS was compared to those elicited by a commercial inactivated vaccine using immunobridging. Based on the detection of rabies virus binding (rVBA) and rabies virus neutralizing antibodies (rVNA) as measured by ELISA and Rapid Fluorescent Focus Inhibition Test (RFFIT) the long-term immune response in dogs vaccinated orally with the SPBNA GASGAS strain of rabies vaccine in a bait was non-inferior to a conventional inactivated rabies vaccine. The outcome of this study supports extending the originally claimed duration of immunity (DOI) of SPBN GASGAS after oral vaccination for dogs from 6 to 30 months.http://www.sciencedirect.com/science/article/pii/S2590136223001511Oral vaccinationDogSPBN GASGASDOIImmunobridgingEfficacy |
| spellingShingle | Ad Vos Suwicha Kasemsuwan Kansuda Leelahapongsathon Katharina Bobe David Perez-Bravo Jeannette Kliemt Parinya Phawaphutayanchi Nirut Aiyara Conrad M. Freuling Thomas Müller Long-term immunity induced by SPBN GASGAS in orally vaccinated dogs is non-inferior to inactivated rabies vaccines Vaccine: X Oral vaccination Dog SPBN GASGAS DOI Immunobridging Efficacy |
| title | Long-term immunity induced by SPBN GASGAS in orally vaccinated dogs is non-inferior to inactivated rabies vaccines |
| title_full | Long-term immunity induced by SPBN GASGAS in orally vaccinated dogs is non-inferior to inactivated rabies vaccines |
| title_fullStr | Long-term immunity induced by SPBN GASGAS in orally vaccinated dogs is non-inferior to inactivated rabies vaccines |
| title_full_unstemmed | Long-term immunity induced by SPBN GASGAS in orally vaccinated dogs is non-inferior to inactivated rabies vaccines |
| title_short | Long-term immunity induced by SPBN GASGAS in orally vaccinated dogs is non-inferior to inactivated rabies vaccines |
| title_sort | long term immunity induced by spbn gasgas in orally vaccinated dogs is non inferior to inactivated rabies vaccines |
| topic | Oral vaccination Dog SPBN GASGAS DOI Immunobridging Efficacy |
| url | http://www.sciencedirect.com/science/article/pii/S2590136223001511 |
| work_keys_str_mv | AT advos longtermimmunityinducedbyspbngasgasinorallyvaccinateddogsisnoninferiortoinactivatedrabiesvaccines AT suwichakasemsuwan longtermimmunityinducedbyspbngasgasinorallyvaccinateddogsisnoninferiortoinactivatedrabiesvaccines AT kansudaleelahapongsathon longtermimmunityinducedbyspbngasgasinorallyvaccinateddogsisnoninferiortoinactivatedrabiesvaccines AT katharinabobe longtermimmunityinducedbyspbngasgasinorallyvaccinateddogsisnoninferiortoinactivatedrabiesvaccines AT davidperezbravo longtermimmunityinducedbyspbngasgasinorallyvaccinateddogsisnoninferiortoinactivatedrabiesvaccines AT jeannettekliemt longtermimmunityinducedbyspbngasgasinorallyvaccinateddogsisnoninferiortoinactivatedrabiesvaccines AT parinyaphawaphutayanchi longtermimmunityinducedbyspbngasgasinorallyvaccinateddogsisnoninferiortoinactivatedrabiesvaccines AT nirutaiyara longtermimmunityinducedbyspbngasgasinorallyvaccinateddogsisnoninferiortoinactivatedrabiesvaccines AT conradmfreuling longtermimmunityinducedbyspbngasgasinorallyvaccinateddogsisnoninferiortoinactivatedrabiesvaccines AT thomasmuller longtermimmunityinducedbyspbngasgasinorallyvaccinateddogsisnoninferiortoinactivatedrabiesvaccines |