Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment
Plasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound healing and cancer treatment—two applications with e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/19/6898 |
| _version_ | 1827705035881971712 |
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| author | Lars Boeckmann Mirijam Schäfer Thoralf Bernhardt Marie Luise Semmler Ole Jung Gregor Ojak Tobias Fischer Kirsten Peters Barbara Nebe Brigitte Müller-Hilke Christian Seebauer Sander Bekeschus Steffen Emmert |
| author_facet | Lars Boeckmann Mirijam Schäfer Thoralf Bernhardt Marie Luise Semmler Ole Jung Gregor Ojak Tobias Fischer Kirsten Peters Barbara Nebe Brigitte Müller-Hilke Christian Seebauer Sander Bekeschus Steffen Emmert |
| author_sort | Lars Boeckmann |
| collection | DOAJ |
| description | Plasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound healing and cancer treatment—two applications with entirely different goals. In wound healing, a tissue-stimulating effect is intended, whereas cancer therapy aims at killing malignant cells. In this review, we provide an overview of the latest clinical and some preclinical research on the efficacy of CAP in wound healing and cancer therapy. Furthermore, we discuss the current understanding of molecular signaling mechanisms triggered by CAP that grant CAP its antiseptic and tissue regenerating or anti-proliferative and cell death-inducing properties. For the efficacy of CAP in wound healing, already substantial evidence from clinical studies is available, while evidence for therapeutic effects of CAP in oncology is mainly from in vitro and in vivo animal studies. Efforts to elucidate the mode of action of CAP suggest that different components, such as ultraviolet (UV) radiation, electromagnetic fields, and reactive species, may act synergistically, with reactive species being regarded as the major effector by modulating complex and concentration-dependent redox signaling pathways. |
| first_indexed | 2024-03-10T15:53:42Z |
| format | Article |
| id | doaj.art-367706cf6fb740dc91adeeecb3f8f6ad |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T15:53:42Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-367706cf6fb740dc91adeeecb3f8f6ad2023-11-20T15:48:08ZengMDPI AGApplied Sciences2076-34172020-10-011019689810.3390/app10196898Cold Atmospheric Pressure Plasma in Wound Healing and Cancer TreatmentLars Boeckmann0Mirijam Schäfer1Thoralf Bernhardt2Marie Luise Semmler3Ole Jung4Gregor Ojak5Tobias Fischer6Kirsten Peters7Barbara Nebe8Brigitte Müller-Hilke9Christian Seebauer10Sander Bekeschus11Steffen Emmert12Clinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyDepartment of Cell Biology, University Medical Center Rostock, 18057 Rostock, GermanyDepartment of Cell Biology, University Medical Center Rostock, 18057 Rostock, GermanyInstitute for Immunology, University Medical Center Rostock, 18057 Rostock, GermanyOral & Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, 17489 Greifswald, GermanyZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), 17489 Greifswald, GermanyClinic and Polyclinic for Dermatology and Venereology, University Medical Center Rostock, 18057 Rostock, GermanyPlasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound healing and cancer treatment—two applications with entirely different goals. In wound healing, a tissue-stimulating effect is intended, whereas cancer therapy aims at killing malignant cells. In this review, we provide an overview of the latest clinical and some preclinical research on the efficacy of CAP in wound healing and cancer therapy. Furthermore, we discuss the current understanding of molecular signaling mechanisms triggered by CAP that grant CAP its antiseptic and tissue regenerating or anti-proliferative and cell death-inducing properties. For the efficacy of CAP in wound healing, already substantial evidence from clinical studies is available, while evidence for therapeutic effects of CAP in oncology is mainly from in vitro and in vivo animal studies. Efforts to elucidate the mode of action of CAP suggest that different components, such as ultraviolet (UV) radiation, electromagnetic fields, and reactive species, may act synergistically, with reactive species being regarded as the major effector by modulating complex and concentration-dependent redox signaling pathways.https://www.mdpi.com/2076-3417/10/19/6898cancer therapycold physical plasmadermatologyplasma medicinereactive oxygen and nitrogen species |
| spellingShingle | Lars Boeckmann Mirijam Schäfer Thoralf Bernhardt Marie Luise Semmler Ole Jung Gregor Ojak Tobias Fischer Kirsten Peters Barbara Nebe Brigitte Müller-Hilke Christian Seebauer Sander Bekeschus Steffen Emmert Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment Applied Sciences cancer therapy cold physical plasma dermatology plasma medicine reactive oxygen and nitrogen species |
| title | Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment |
| title_full | Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment |
| title_fullStr | Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment |
| title_full_unstemmed | Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment |
| title_short | Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment |
| title_sort | cold atmospheric pressure plasma in wound healing and cancer treatment |
| topic | cancer therapy cold physical plasma dermatology plasma medicine reactive oxygen and nitrogen species |
| url | https://www.mdpi.com/2076-3417/10/19/6898 |
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