Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric Cancer
<b>Objective: </b>The prognostic value of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index has been studied in many cancer types. Our aim is to show the prognostic value of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and sy...
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| Format: | Article |
| Language: | English |
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National Scientific Medical Center
2019-12-01
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| Series: | Ķazaķstannyṇ Klinikalyķ Medicinasy |
| Subjects: | |
| Online Access: | https://www.clinmedkaz.org/download/prognostic-value-of-neutrophil-lymphocyte-ratio-platelet-lymphocyte-ratio-and-systemic-9076.pdf |
| _version_ | 1818501604269096960 |
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| author | Hayriye Şahinli Sema Türker |
| author_facet | Hayriye Şahinli Sema Türker |
| author_sort | Hayriye Şahinli |
| collection | DOAJ |
| description | <b>Objective: </b>The prognostic value of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index has been studied in many cancer types. Our aim is to show the prognostic value of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index in resected gastric cancer patients. In addition, to determine which parameter is a better predictor of survival.<br>
<b>Material and methods:</b> The study included 95 patients resected gastric cancer between 2014-2018. Receiver operating curve analysis was used to determine neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index cut-off values. Systemic immune-inflammatory index was evaluated as neutrophil × platelet/lymphocyte. Long rank and cox regression analysis were used.<br>
<b>Results: </b>The median age was 62 (22-84) years. The median overall survival was 33 months. 49 (51.6%) patients were in stage 3 and 46 (48.4 %) patients were in stage 1-2. High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index values, tumor depth, stage of metastatic lymph node and tumor-node-metastasis stage were poor prognostic factors for overall survival and disease-free survival. When multivariant cox regression analysis was performed, only platelet-lymphocyte ratio was found to be independent prognostic factor (p = 0.037 for overall survival, p = 0.024 for overall survival).<br>
<b>Conclusion</b>: High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index were found to be poor prognostic factors in predicting both overall survival and disease-free survival before treatment in patients who undergo curative resection for gastric cancer. As a result of multivariant analysis, only high platelet-lymphocyte ratio was determined as an independent poor prognostic factor for both overall survival and disease-free survival. |
| first_indexed | 2024-12-10T20:58:34Z |
| format | Article |
| id | doaj.art-3677bfa19c794fa48bdc72f17374fec3 |
| institution | Directory Open Access Journal |
| issn | 1812-2892 2313-1519 |
| language | English |
| last_indexed | 2024-12-10T20:58:34Z |
| publishDate | 2019-12-01 |
| publisher | National Scientific Medical Center |
| record_format | Article |
| series | Ķazaķstannyṇ Klinikalyķ Medicinasy |
| spelling | doaj.art-3677bfa19c794fa48bdc72f17374fec32022-12-22T01:33:52ZengNational Scientific Medical CenterĶazaķstannyṇ Klinikalyķ Medicinasy1812-28922313-15192019-12-01454343910.23950/1812-2892-JCMK-00724Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric CancerHayriye Şahinli0Sema Türker1Department of Medical Oncology, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, TurkeyDepartment of Medical Oncology, Ankara Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey<b>Objective: </b>The prognostic value of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index has been studied in many cancer types. Our aim is to show the prognostic value of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index in resected gastric cancer patients. In addition, to determine which parameter is a better predictor of survival.<br> <b>Material and methods:</b> The study included 95 patients resected gastric cancer between 2014-2018. Receiver operating curve analysis was used to determine neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index cut-off values. Systemic immune-inflammatory index was evaluated as neutrophil × platelet/lymphocyte. Long rank and cox regression analysis were used.<br> <b>Results: </b>The median age was 62 (22-84) years. The median overall survival was 33 months. 49 (51.6%) patients were in stage 3 and 46 (48.4 %) patients were in stage 1-2. High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index values, tumor depth, stage of metastatic lymph node and tumor-node-metastasis stage were poor prognostic factors for overall survival and disease-free survival. When multivariant cox regression analysis was performed, only platelet-lymphocyte ratio was found to be independent prognostic factor (p = 0.037 for overall survival, p = 0.024 for overall survival).<br> <b>Conclusion</b>: High neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic immune-inflammatory index were found to be poor prognostic factors in predicting both overall survival and disease-free survival before treatment in patients who undergo curative resection for gastric cancer. As a result of multivariant analysis, only high platelet-lymphocyte ratio was determined as an independent poor prognostic factor for both overall survival and disease-free survival.https://www.clinmedkaz.org/download/prognostic-value-of-neutrophil-lymphocyte-ratio-platelet-lymphocyte-ratio-and-systemic-9076.pdfgastric cancerneutrophil-lymphocyte ratioplatelet-lymphocyte ratioprognosis |
| spellingShingle | Hayriye Şahinli Sema Türker Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric Cancer Ķazaķstannyṇ Klinikalyķ Medicinasy gastric cancer neutrophil-lymphocyte ratio platelet-lymphocyte ratio prognosis |
| title | Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric Cancer |
| title_full | Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric Cancer |
| title_fullStr | Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric Cancer |
| title_full_unstemmed | Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric Cancer |
| title_short | Prognostic Value of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Systemic Immune-Inflammatory Index in Resected Gastric Cancer |
| title_sort | prognostic value of neutrophil lymphocyte ratio platelet lymphocyte ratio and systemic immune inflammatory index in resected gastric cancer |
| topic | gastric cancer neutrophil-lymphocyte ratio platelet-lymphocyte ratio prognosis |
| url | https://www.clinmedkaz.org/download/prognostic-value-of-neutrophil-lymphocyte-ratio-platelet-lymphocyte-ratio-and-systemic-9076.pdf |
| work_keys_str_mv | AT hayriyesahinli prognosticvalueofneutrophillymphocyteratioplateletlymphocyteratioandsystemicimmuneinflammatoryindexinresectedgastriccancer AT sematurker prognosticvalueofneutrophillymphocyteratioplateletlymphocyteratioandsystemicimmuneinflammatoryindexinresectedgastriccancer |