Is a High HDL-Cholesterol Level Always Beneficial?
The specific interest concerning HDL cholesterol (HDL-C) is related to its ability to uptake and return surplus cholesterol from peripheral tissues back to the liver and, therefore, to its role in the prevention of cardiovascular diseases, such as atherosclerosis and myocardial infarction, but also...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/9/1083 |
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| author | Beata Franczyk Jacek Rysz Janusz Ławiński Magdalena Rysz-Górzyńska Anna Gluba-Brzózka |
| author_facet | Beata Franczyk Jacek Rysz Janusz Ławiński Magdalena Rysz-Górzyńska Anna Gluba-Brzózka |
| author_sort | Beata Franczyk |
| collection | DOAJ |
| description | The specific interest concerning HDL cholesterol (HDL-C) is related to its ability to uptake and return surplus cholesterol from peripheral tissues back to the liver and, therefore, to its role in the prevention of cardiovascular diseases, such as atherosclerosis and myocardial infarction, but also transient ischemic attack and stroke. Previous epidemiological studies have indicated that HDL-C concentration is inversely associated with the risk of cardiovascular disease and that it can be used for risk prediction. Some genetic disorders are characterized by markedly elevated levels of HDL-C; however, they do not translate into diminished cardiovascular risk. The search of the potential causative relationship between HDL-C and adverse events has shifted the attention of researchers towards the composition and function of the HDL molecule/subfractions. HDL possesses various cardioprotective properties. However, currently, it appears that higher HDL-C is not necessarily protective against cardiovascular disease, but it can even be harmful in extremely high quantities. |
| first_indexed | 2024-03-10T07:53:02Z |
| format | Article |
| id | doaj.art-367aed79821d4543b48cfda101c7eef3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T07:53:02Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-367aed79821d4543b48cfda101c7eef32023-11-22T12:06:45ZengMDPI AGBiomedicines2227-90592021-08-0199108310.3390/biomedicines9091083Is a High HDL-Cholesterol Level Always Beneficial?Beata Franczyk0Jacek Rysz1Janusz Ławiński2Magdalena Rysz-Górzyńska3Anna Gluba-Brzózka4Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 90-549 Lodz, PolandDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 90-549 Lodz, PolandDepartment of Urology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-549 Rzeszow, PolandDepartment of Ophthalmology and Visual Rehabilitation, Medical University of Lodz, 90-549 Lodz, PolandDepartment of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, 90-549 Lodz, PolandThe specific interest concerning HDL cholesterol (HDL-C) is related to its ability to uptake and return surplus cholesterol from peripheral tissues back to the liver and, therefore, to its role in the prevention of cardiovascular diseases, such as atherosclerosis and myocardial infarction, but also transient ischemic attack and stroke. Previous epidemiological studies have indicated that HDL-C concentration is inversely associated with the risk of cardiovascular disease and that it can be used for risk prediction. Some genetic disorders are characterized by markedly elevated levels of HDL-C; however, they do not translate into diminished cardiovascular risk. The search of the potential causative relationship between HDL-C and adverse events has shifted the attention of researchers towards the composition and function of the HDL molecule/subfractions. HDL possesses various cardioprotective properties. However, currently, it appears that higher HDL-C is not necessarily protective against cardiovascular disease, but it can even be harmful in extremely high quantities.https://www.mdpi.com/2227-9059/9/9/1083high-density lipoproteinhigh levelsdysfunctional HDLcardiovascular risk |
| spellingShingle | Beata Franczyk Jacek Rysz Janusz Ławiński Magdalena Rysz-Górzyńska Anna Gluba-Brzózka Is a High HDL-Cholesterol Level Always Beneficial? Biomedicines high-density lipoprotein high levels dysfunctional HDL cardiovascular risk |
| title | Is a High HDL-Cholesterol Level Always Beneficial? |
| title_full | Is a High HDL-Cholesterol Level Always Beneficial? |
| title_fullStr | Is a High HDL-Cholesterol Level Always Beneficial? |
| title_full_unstemmed | Is a High HDL-Cholesterol Level Always Beneficial? |
| title_short | Is a High HDL-Cholesterol Level Always Beneficial? |
| title_sort | is a high hdl cholesterol level always beneficial |
| topic | high-density lipoprotein high levels dysfunctional HDL cardiovascular risk |
| url | https://www.mdpi.com/2227-9059/9/9/1083 |
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