Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform

Identification of Potential Serum Protein Biomarkers and Pathways for Pancreatic Cancer Cachexia Using an Aptamer-Based Discovery Platform

Patients with pancreatic ductal adenocarcinoma (PDAC) suffer debilitating and deadly weight loss, known as cachexia. Development of therapies requires biomarkers to diagnose, and monitor cachexia; however, no such markers are in use. Via Somascan, we measured ~1300 plasma proteins in 30 patients wit...

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Bibliographic Details
Main Authors: Ashok Narasimhan, Safi Shahda, Joshua K. Kays, Susan M. Perkins, Lijun Cheng, Katheryn N. H. Schloss, Daniel E. I. Schloss, Leonidas G. Koniaris, Teresa A. Zimmers
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
pancreatic adenocarcinoma
cachexia
biomarkers
humans
neoplasms
proteome
Online Access:https://www.mdpi.com/2072-6694/12/12/3787

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