Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells

Interleukin-8 Secreted by Glioblastoma Cells Induces Microvascular Hyperpermeability Through NO Signaling Involving S-Nitrosylation of VE-Cadherin and p120 in Endothelial Cells

Glioblastoma is a highly aggressive brain tumor, characterized by the formation of dysfunctional blood vessels and a permeable endothelial barrier. S-nitrosylation, a post-translational modification, has been identified as a regulator of endothelial function. In this work we explored whether S-nitro...

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Bibliographic Details
Main Authors: Anita Guequén, Patricia Zamorano, Francisco Córdova, Tania Koning, Angelo Torres, Pamela Ehrenfeld, Mauricio P. Boric, Flavio Salazar-Onfray, Julie Gavard, Walter N. Durán, Claudia Quezada, José Sarmiento, Fabiola A. Sánchez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Physiology
Subjects:
adherens junction
glioblastoma
endothelial permeability
S-nitrosylation
VE-cadherin
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00988/full

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