Maintaining Digestive Health in Diabetes: The Role of the Gut Microbiome and the Challenge of Functional Foods
Over the last decades, the incidence of diabetes has increased in developed countries and beyond the genetic impact, environmental factors, which can trigger the activation of the gut immune system, seem to affect the induction of the disease process. Since the composition of the gut microbiome migh...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/3/516 |
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| author | Eugenia Bezirtzoglou Elisavet Stavropoulou Konstantina Kantartzi Christina Tsigalou Chrysa Voidarou Gregoria Mitropoulou Ioanna Prapa Valentini Santarmaki Vasiliki Kompoura Amalia E. Yanni Maria Antoniadou Theodoros Varzakas Yiannis Kourkoutas |
| author_facet | Eugenia Bezirtzoglou Elisavet Stavropoulou Konstantina Kantartzi Christina Tsigalou Chrysa Voidarou Gregoria Mitropoulou Ioanna Prapa Valentini Santarmaki Vasiliki Kompoura Amalia E. Yanni Maria Antoniadou Theodoros Varzakas Yiannis Kourkoutas |
| author_sort | Eugenia Bezirtzoglou |
| collection | DOAJ |
| description | Over the last decades, the incidence of diabetes has increased in developed countries and beyond the genetic impact, environmental factors, which can trigger the activation of the gut immune system, seem to affect the induction of the disease process. Since the composition of the gut microbiome might disturb the normal interaction with the immune system and contribute to altered immune responses, the restoration of normal microbiota composition constitutes a new target for the prevention and treatment of diabetes. Thus, the interaction of gut microbiome and diabetes, focusing on mechanisms connecting gut microbiota with the occurrence of the disorder, is discussed in the present review. Finally, the challenge of functional food diet on maintaining intestinal health and microbial flora diversity and functionality, as a potential tool for the onset inhibition and management of the disease, is highlighted by reporting key animal studies and clinical trials. Early onset of the disease in the oral cavity is an important factor for the incorporation of a functional food diet in daily routine. |
| first_indexed | 2024-03-09T05:47:57Z |
| format | Article |
| id | doaj.art-367ffc471cce4710909f183b83454444 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T05:47:57Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-367ffc471cce4710909f183b834544442023-12-03T12:19:15ZengMDPI AGMicroorganisms2076-26072021-03-019351610.3390/microorganisms9030516Maintaining Digestive Health in Diabetes: The Role of the Gut Microbiome and the Challenge of Functional FoodsEugenia Bezirtzoglou0Elisavet Stavropoulou1Konstantina Kantartzi2Christina Tsigalou3Chrysa Voidarou4Gregoria Mitropoulou5Ioanna Prapa6Valentini Santarmaki7Vasiliki Kompoura8Amalia E. Yanni9Maria Antoniadou10Theodoros Varzakas11Yiannis Kourkoutas12Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, GreeceCentre Hospitalier Universitaire Vaudois (CHUV), rue du Bugnon, 1011 Lausanne, SwitzerlandDepartment of Medicine, Nephrology Clinic, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, GreeceLaboratory of Microbiology, Department of Medicine, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, GreeceDepartment of Public Health P.U., Prefecture of Epirus, 47132 Arta, GreeceLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, GreeceLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, GreeceLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, GreeceLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, GreeceLaboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Nutrition and Dietetics, Harokopion University, 17671 Athens, GreeceDental School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Food Science and Technology, University of the Peloponnese, 24100 Kalamata, GreeceLaboratory of Applied Microbiology and Biotechnology, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Dragana, Alexandroupolis, GreeceOver the last decades, the incidence of diabetes has increased in developed countries and beyond the genetic impact, environmental factors, which can trigger the activation of the gut immune system, seem to affect the induction of the disease process. Since the composition of the gut microbiome might disturb the normal interaction with the immune system and contribute to altered immune responses, the restoration of normal microbiota composition constitutes a new target for the prevention and treatment of diabetes. Thus, the interaction of gut microbiome and diabetes, focusing on mechanisms connecting gut microbiota with the occurrence of the disorder, is discussed in the present review. Finally, the challenge of functional food diet on maintaining intestinal health and microbial flora diversity and functionality, as a potential tool for the onset inhibition and management of the disease, is highlighted by reporting key animal studies and clinical trials. Early onset of the disease in the oral cavity is an important factor for the incorporation of a functional food diet in daily routine.https://www.mdpi.com/2076-2607/9/3/516diabetesfermented foodsfunctional foodsgut microbiomedigestive healthnutrition |
| spellingShingle | Eugenia Bezirtzoglou Elisavet Stavropoulou Konstantina Kantartzi Christina Tsigalou Chrysa Voidarou Gregoria Mitropoulou Ioanna Prapa Valentini Santarmaki Vasiliki Kompoura Amalia E. Yanni Maria Antoniadou Theodoros Varzakas Yiannis Kourkoutas Maintaining Digestive Health in Diabetes: The Role of the Gut Microbiome and the Challenge of Functional Foods Microorganisms diabetes fermented foods functional foods gut microbiome digestive health nutrition |
| title | Maintaining Digestive Health in Diabetes: The Role of the Gut Microbiome and the Challenge of Functional Foods |
| title_full | Maintaining Digestive Health in Diabetes: The Role of the Gut Microbiome and the Challenge of Functional Foods |
| title_fullStr | Maintaining Digestive Health in Diabetes: The Role of the Gut Microbiome and the Challenge of Functional Foods |
| title_full_unstemmed | Maintaining Digestive Health in Diabetes: The Role of the Gut Microbiome and the Challenge of Functional Foods |
| title_short | Maintaining Digestive Health in Diabetes: The Role of the Gut Microbiome and the Challenge of Functional Foods |
| title_sort | maintaining digestive health in diabetes the role of the gut microbiome and the challenge of functional foods |
| topic | diabetes fermented foods functional foods gut microbiome digestive health nutrition |
| url | https://www.mdpi.com/2076-2607/9/3/516 |
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