Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals
Neurochemicals, crucial for nervous system function, influence vital bodily processes and their fluctuations are linked to neurodegenerative diseases and mental health conditions. Monitoring these compounds is pivotal, yet the intricate nature of the central nervous system poses challenges. Research...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/14/3/125 |
| _version_ | 1797241852077801472 |
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| author | Xiaoxuan Xu Yimei Zuo Shu Chen Amir Hatami Hui Gu |
| author_facet | Xiaoxuan Xu Yimei Zuo Shu Chen Amir Hatami Hui Gu |
| author_sort | Xiaoxuan Xu |
| collection | DOAJ |
| description | Neurochemicals, crucial for nervous system function, influence vital bodily processes and their fluctuations are linked to neurodegenerative diseases and mental health conditions. Monitoring these compounds is pivotal, yet the intricate nature of the central nervous system poses challenges. Researchers have devised methods, notably electrochemical sensing with micro-nanoscale electrodes, offering high-resolution monitoring despite low concentrations and rapid changes. Implantable sensors enable precise detection in brain tissues with minimal damage, while microdialysis-coupled platforms allow in vivo sampling and subsequent in vitro analysis, addressing the selectivity issues seen in other methods. While lacking temporal resolution, techniques like HPLC and CE complement electrochemical sensing’s selectivity, particularly for structurally similar neurochemicals. This review covers essential neurochemicals and explores miniaturized electrochemical sensors for brain analysis, emphasizing microdialysis integration. It discusses the pros and cons of these techniques, forecasting electrochemical sensing’s future in neuroscience research. Overall, this comprehensive review outlines the evolution, strengths, and potential applications of electrochemical sensing in the study of neurochemicals, offering insights into future advancements in the field. |
| first_indexed | 2024-04-24T18:29:54Z |
| format | Article |
| id | doaj.art-3682f22367f84bec85795cc411177449 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-04-24T18:29:54Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-3682f22367f84bec85795cc4111774492024-03-27T13:28:11ZengMDPI AGBiosensors2079-63742024-02-0114312510.3390/bios14030125Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of NeurochemicalsXiaoxuan Xu0Yimei Zuo1Shu Chen2Amir Hatami3Hui Gu4Key Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, ChinaKey Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, ChinaKey Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, ChinaDepartment of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Prof. Sobouti Boulevard, P.O. Box 45195-1159, Zanjan 45137-66731, IranKey Laboratory of Theoretical Organic Chemistry and Functional Molecule of Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, ChinaNeurochemicals, crucial for nervous system function, influence vital bodily processes and their fluctuations are linked to neurodegenerative diseases and mental health conditions. Monitoring these compounds is pivotal, yet the intricate nature of the central nervous system poses challenges. Researchers have devised methods, notably electrochemical sensing with micro-nanoscale electrodes, offering high-resolution monitoring despite low concentrations and rapid changes. Implantable sensors enable precise detection in brain tissues with minimal damage, while microdialysis-coupled platforms allow in vivo sampling and subsequent in vitro analysis, addressing the selectivity issues seen in other methods. While lacking temporal resolution, techniques like HPLC and CE complement electrochemical sensing’s selectivity, particularly for structurally similar neurochemicals. This review covers essential neurochemicals and explores miniaturized electrochemical sensors for brain analysis, emphasizing microdialysis integration. It discusses the pros and cons of these techniques, forecasting electrochemical sensing’s future in neuroscience research. Overall, this comprehensive review outlines the evolution, strengths, and potential applications of electrochemical sensing in the study of neurochemicals, offering insights into future advancements in the field.https://www.mdpi.com/2079-6374/14/3/125neurochemicalsbioanalysismicroelectrode |
| spellingShingle | Xiaoxuan Xu Yimei Zuo Shu Chen Amir Hatami Hui Gu Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals Biosensors neurochemicals bioanalysis microelectrode |
| title | Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals |
| title_full | Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals |
| title_fullStr | Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals |
| title_full_unstemmed | Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals |
| title_short | Advancements in Brain Research: The In Vivo/In Vitro Electrochemical Detection of Neurochemicals |
| title_sort | advancements in brain research the in vivo in vitro electrochemical detection of neurochemicals |
| topic | neurochemicals bioanalysis microelectrode |
| url | https://www.mdpi.com/2079-6374/14/3/125 |
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