Durable Remission with Immunotherapy in a Patient with Sarcomatoid Renal Cell Carcinoma
Sarcomatoid differentiation is a rare and aggressive histologic subtype with poor prognosis, seen in several malignancies. In sarcomatoid renal cell carcinoma (RCC), the degree of sarcomatoid differentiation and the stage at presentation determines the prognosis. Despite resection, chemotherapy and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Codon Publications
2021-10-01
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| Series: | Journal of Kidney Cancer and VHL |
| Subjects: | |
| Online Access: | https://jkcvhl.com/index.php/jkcvhl/article/view/168 |
| _version_ | 1811191330837102592 |
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| author | Nwabundo Anusim Damilola Gbadebo Olabisi Afolayan-Oloye Ishmael Jaiyesimi |
| author_facet | Nwabundo Anusim Damilola Gbadebo Olabisi Afolayan-Oloye Ishmael Jaiyesimi |
| author_sort | Nwabundo Anusim |
| collection | DOAJ |
| description | Sarcomatoid differentiation is a rare and aggressive histologic subtype with poor prognosis, seen in several malignancies. In sarcomatoid renal cell carcinoma (RCC), the degree of sarcomatoid differentiation and the stage at presentation determines the prognosis. Despite resection, chemotherapy and targeted therapy response is modest, with relapse usually occurring within a few months. We present a case of a gentleman with sarcomatoid RCC managed with pembrolizumab, who has had no evidence of recurrence for over 4 years since the last dose of immunotherapy. RCCs with sarcomatoid differentiation have a high presence of programmed cell death protein 1 and programmed cell death ligand 1 in T cells and tumor cells, respectively, making immunotherapy an attractive option in this setting. Clinical trials are ongoing to further define the benefit of immunotherapy in sarcomatoid RCC. |
| first_indexed | 2024-04-11T15:04:52Z |
| format | Article |
| id | doaj.art-3683277229354733abecfae3b7fc8f54 |
| institution | Directory Open Access Journal |
| issn | 2203-5826 |
| language | English |
| last_indexed | 2024-04-11T15:04:52Z |
| publishDate | 2021-10-01 |
| publisher | Codon Publications |
| record_format | Article |
| series | Journal of Kidney Cancer and VHL |
| spelling | doaj.art-3683277229354733abecfae3b7fc8f542022-12-22T04:16:50ZengCodon PublicationsJournal of Kidney Cancer and VHL2203-58262021-10-018410.15586/jkcvhl.v8i4.168Durable Remission with Immunotherapy in a Patient with Sarcomatoid Renal Cell CarcinomaNwabundo Anusim0Damilola Gbadebo1 Olabisi Afolayan-Oloye2Ishmael Jaiyesimi3Department of Hematology and Oncology, Beaumont Health, Royal Oak, MI, USADepartment of Hematology and Oncology, Beaumont Health, Royal Oak, MI, USADepartment of Hematology and Oncology, Beaumont Health, Royal Oak, MI, USADepartment of Hematology and Oncology, Beaumont Health, Royal Oak, MI, USASarcomatoid differentiation is a rare and aggressive histologic subtype with poor prognosis, seen in several malignancies. In sarcomatoid renal cell carcinoma (RCC), the degree of sarcomatoid differentiation and the stage at presentation determines the prognosis. Despite resection, chemotherapy and targeted therapy response is modest, with relapse usually occurring within a few months. We present a case of a gentleman with sarcomatoid RCC managed with pembrolizumab, who has had no evidence of recurrence for over 4 years since the last dose of immunotherapy. RCCs with sarcomatoid differentiation have a high presence of programmed cell death protein 1 and programmed cell death ligand 1 in T cells and tumor cells, respectively, making immunotherapy an attractive option in this setting. Clinical trials are ongoing to further define the benefit of immunotherapy in sarcomatoid RCC.https://jkcvhl.com/index.php/jkcvhl/article/view/168case study; immunotherapy; renal cell carcinoma; sarcomatoid differentiation |
| spellingShingle | Nwabundo Anusim Damilola Gbadebo Olabisi Afolayan-Oloye Ishmael Jaiyesimi Durable Remission with Immunotherapy in a Patient with Sarcomatoid Renal Cell Carcinoma Journal of Kidney Cancer and VHL case study; immunotherapy; renal cell carcinoma; sarcomatoid differentiation |
| title | Durable Remission with Immunotherapy in a Patient with Sarcomatoid Renal Cell Carcinoma |
| title_full | Durable Remission with Immunotherapy in a Patient with Sarcomatoid Renal Cell Carcinoma |
| title_fullStr | Durable Remission with Immunotherapy in a Patient with Sarcomatoid Renal Cell Carcinoma |
| title_full_unstemmed | Durable Remission with Immunotherapy in a Patient with Sarcomatoid Renal Cell Carcinoma |
| title_short | Durable Remission with Immunotherapy in a Patient with Sarcomatoid Renal Cell Carcinoma |
| title_sort | durable remission with immunotherapy in a patient with sarcomatoid renal cell carcinoma |
| topic | case study; immunotherapy; renal cell carcinoma; sarcomatoid differentiation |
| url | https://jkcvhl.com/index.php/jkcvhl/article/view/168 |
| work_keys_str_mv | AT nwabundoanusim durableremissionwithimmunotherapyinapatientwithsarcomatoidrenalcellcarcinoma AT damilolagbadebo durableremissionwithimmunotherapyinapatientwithsarcomatoidrenalcellcarcinoma AT olabisiafolayanoloye durableremissionwithimmunotherapyinapatientwithsarcomatoidrenalcellcarcinoma AT ishmaeljaiyesimi durableremissionwithimmunotherapyinapatientwithsarcomatoidrenalcellcarcinoma |