Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciency
Fertility in women with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) appears to be reduced, especially in women with the classic salt-wasting type. Several factors have been suggested to contribute to this subfertility such as androgen excess, adrenal progesterone h...
| Glavni autori: | , , , , , , , |
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| Format: | Članak |
| Jezik: | English |
| Izdano: |
Wolters Kluwer Medknow Publications
2013-01-01
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| Serija: | Indian Journal of Endocrinology and Metabolism |
| Teme: | |
| Online pristup: | http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=5;spage=790;epage=793;aulast=Mnif |
| _version_ | 1828778867654918144 |
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| author | Mouna Feki Mnif Mahdi Kamoun Faten Hadj Kacem Fatma Mnif Nadia Charfi Basma Ben Naceur Nabila Rekik Mohamed Abid |
| author_facet | Mouna Feki Mnif Mahdi Kamoun Faten Hadj Kacem Fatma Mnif Nadia Charfi Basma Ben Naceur Nabila Rekik Mohamed Abid |
| author_sort | Mouna Feki Mnif |
| collection | DOAJ |
| description | Fertility in women with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) appears to be reduced, especially in women with the classic salt-wasting type. Several factors have been suggested to contribute to this subfertility such as androgen excess, adrenal progesterone hypersecretion, consequences of genital reconstructive surgery, secondary polycystic ovaries syndrome, and psychosexual factors. In contrast to this subfertility, pregnancies are commonly normal and uneventful. Adequate glucocorticoid therapy and improvement of surgical and psychological management could contribute to optimize fertility in CAH female patients, even among women with the classic variant. This review provides current information regarding the reproductive outcomes of women with CAH due to 21-OHD and the fertility and pregnancy issues in this population. |
| first_indexed | 2024-12-11T16:50:50Z |
| format | Article |
| id | doaj.art-3683a90bc5f045fbabf7a3a75e4b66c5 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-11T16:50:50Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-3683a90bc5f045fbabf7a3a75e4b66c52022-12-22T00:58:06ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002013-01-0117579079310.4103/2230-8210.117196Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciencyMouna Feki MnifMahdi KamounFaten Hadj KacemFatma MnifNadia CharfiBasma Ben NaceurNabila RekikMohamed AbidFertility in women with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) appears to be reduced, especially in women with the classic salt-wasting type. Several factors have been suggested to contribute to this subfertility such as androgen excess, adrenal progesterone hypersecretion, consequences of genital reconstructive surgery, secondary polycystic ovaries syndrome, and psychosexual factors. In contrast to this subfertility, pregnancies are commonly normal and uneventful. Adequate glucocorticoid therapy and improvement of surgical and psychological management could contribute to optimize fertility in CAH female patients, even among women with the classic variant. This review provides current information regarding the reproductive outcomes of women with CAH due to 21-OHD and the fertility and pregnancy issues in this population.http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=5;spage=790;epage=793;aulast=MnifCongenital adrenal hyperplasiafertility21-hydroxylase deficiencypregnancy |
| spellingShingle | Mouna Feki Mnif Mahdi Kamoun Faten Hadj Kacem Fatma Mnif Nadia Charfi Basma Ben Naceur Nabila Rekik Mohamed Abid Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciency Indian Journal of Endocrinology and Metabolism Congenital adrenal hyperplasia fertility 21-hydroxylase deficiency pregnancy |
| title | Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciency |
| title_full | Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciency |
| title_fullStr | Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciency |
| title_full_unstemmed | Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciency |
| title_short | Reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21-hydroxylase defi ciency |
| title_sort | reproductive outcomes of female patients with congenital adrenal hyperplasia due to 21 hydroxylase defi ciency |
| topic | Congenital adrenal hyperplasia fertility 21-hydroxylase deficiency pregnancy |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2013;volume=17;issue=5;spage=790;epage=793;aulast=Mnif |
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