Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-Analysis
BackgroundMetabolic syndrome (MetS) has been related to increased risks of a variety of cancers. However, the association between MetS and the risk of renal cell cancer (RCC) remains not fully determined. This meta-analysis was conducted to investigate whether MetS is independently associated with t...
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| Format: | Article |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.928619/full |
| _version_ | 1811238955046141952 |
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| author | Wurong Du Kaibo Guo Kaibo Guo Huimin Jin Leitao Sun Leitao Sun Shanming Ruan Shanming Ruan Qiaoling Song Qiaoling Song |
| author_facet | Wurong Du Kaibo Guo Kaibo Guo Huimin Jin Leitao Sun Leitao Sun Shanming Ruan Shanming Ruan Qiaoling Song Qiaoling Song |
| author_sort | Wurong Du |
| collection | DOAJ |
| description | BackgroundMetabolic syndrome (MetS) has been related to increased risks of a variety of cancers. However, the association between MetS and the risk of renal cell cancer (RCC) remains not fully determined. This meta-analysis was conducted to investigate whether MetS is independently associated with the risk of RCC in adults.MethodsRelevant observational studies were obtained by searching PubMed, Embase, Cochrane’s Library, and Web of Science databases. Study characteristics and outcome data were extracted independently by two authors. The random-effect model was used for meta-analysis considering the possible influence of between-study heterogeneity. Predefined subgroup analyses were used to evaluate the possible influences of study characteristics on the outcome.ResultsEight studies involving 10,601,006 participants contributed to the meta-analysis. Results showed that MetS was independently associated with a higher risk of RCC in adult population (risk ratio [RR]: 1.62, 95% confidence interval [CI]: 1.41 to 1.87, p<0.001; I2 = 85%). Subgroup analyses showed consistent association in men (RR: 1.52, 95% CI: 1.23 to 1.89, p<0.001) and in women (RR: 1.71, 95% CI: 1.28 to 2.27, p<0.001), in Asians (RR: 1.51, 95% CI: 1.25 to 1.83, p<0.001) and in Caucasians (RR: 1.76, 95% CI: 1.46 to 2.12, p<0.001), and in community derived (RR: 1.56, 95% CI: 1.34 to 1.82, p<0.001) and non-community derived population (RR: 1.87, 95% CI: 1.71 to 2.04, p<0.001). Differences in study design or quality score also did not significantly affect the association (p for subgroup difference both >0.05).ConclusionsMetS may be independently associated with RCC in adult population. |
| first_indexed | 2024-04-12T12:51:23Z |
| format | Article |
| id | doaj.art-3684dc7ea16a440b81b3c39bc575dfdc |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T12:51:23Z |
| publishDate | 2022-06-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-3684dc7ea16a440b81b3c39bc575dfdc2022-12-22T03:32:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.928619928619Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-AnalysisWurong Du0Kaibo Guo1Kaibo Guo2Huimin Jin3Leitao Sun4Leitao Sun5Shanming Ruan6Shanming Ruan7Qiaoling Song8Qiaoling Song9The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Oncology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Oncology, The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaOncology Department, The Second Affiliated Hospital of Zhejiang Chinese Medical University (Xinhua Hospital of Zhejiang Province), Hangzhou, ChinaThe First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaThe First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaThe First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, ChinaEducation Department, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, ChinaBackgroundMetabolic syndrome (MetS) has been related to increased risks of a variety of cancers. However, the association between MetS and the risk of renal cell cancer (RCC) remains not fully determined. This meta-analysis was conducted to investigate whether MetS is independently associated with the risk of RCC in adults.MethodsRelevant observational studies were obtained by searching PubMed, Embase, Cochrane’s Library, and Web of Science databases. Study characteristics and outcome data were extracted independently by two authors. The random-effect model was used for meta-analysis considering the possible influence of between-study heterogeneity. Predefined subgroup analyses were used to evaluate the possible influences of study characteristics on the outcome.ResultsEight studies involving 10,601,006 participants contributed to the meta-analysis. Results showed that MetS was independently associated with a higher risk of RCC in adult population (risk ratio [RR]: 1.62, 95% confidence interval [CI]: 1.41 to 1.87, p<0.001; I2 = 85%). Subgroup analyses showed consistent association in men (RR: 1.52, 95% CI: 1.23 to 1.89, p<0.001) and in women (RR: 1.71, 95% CI: 1.28 to 2.27, p<0.001), in Asians (RR: 1.51, 95% CI: 1.25 to 1.83, p<0.001) and in Caucasians (RR: 1.76, 95% CI: 1.46 to 2.12, p<0.001), and in community derived (RR: 1.56, 95% CI: 1.34 to 1.82, p<0.001) and non-community derived population (RR: 1.87, 95% CI: 1.71 to 2.04, p<0.001). Differences in study design or quality score also did not significantly affect the association (p for subgroup difference both >0.05).ConclusionsMetS may be independently associated with RCC in adult population.https://www.frontiersin.org/articles/10.3389/fonc.2022.928619/fullmetabolic syndromerenal cell cancerrisk factorobesitymeta-analysis |
| spellingShingle | Wurong Du Kaibo Guo Kaibo Guo Huimin Jin Leitao Sun Leitao Sun Shanming Ruan Shanming Ruan Qiaoling Song Qiaoling Song Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-Analysis Frontiers in Oncology metabolic syndrome renal cell cancer risk factor obesity meta-analysis |
| title | Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-Analysis |
| title_full | Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-Analysis |
| title_fullStr | Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-Analysis |
| title_full_unstemmed | Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-Analysis |
| title_short | Association Between Metabolic Syndrome and Risk of Renal Cell Cancer: A Meta-Analysis |
| title_sort | association between metabolic syndrome and risk of renal cell cancer a meta analysis |
| topic | metabolic syndrome renal cell cancer risk factor obesity meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.928619/full |
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