Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change
Abstract Spaceflight associated neuro-ocular syndrome (SANS) is common amongst astronauts on long duration space missions and is associated with signs consistent with elevated cerebrospinal fluid (CSF) pressure. Additionally, CSF pressure has been found to be elevated in a significant proportion of...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
|
| Series: | npj Microgravity |
| Online Access: | https://doi.org/10.1038/s41526-023-00269-0 |
| _version_ | 1797420965336973312 |
|---|---|
| author | W. H. Morgan J. Khoo A. Vukmirovic A. Abdul-Rahman D. An A. Mehnert D. Obreschkow E. Chowdhury D. Y. Yu |
| author_facet | W. H. Morgan J. Khoo A. Vukmirovic A. Abdul-Rahman D. An A. Mehnert D. Obreschkow E. Chowdhury D. Y. Yu |
| author_sort | W. H. Morgan |
| collection | DOAJ |
| description | Abstract Spaceflight associated neuro-ocular syndrome (SANS) is common amongst astronauts on long duration space missions and is associated with signs consistent with elevated cerebrospinal fluid (CSF) pressure. Additionally, CSF pressure has been found to be elevated in a significant proportion of astronauts in whom lumbar puncture was performed after successful mission completion. We have developed a retinal photoplethysmographic technique to measure retinal vein pulsation amplitudes. This technique has enabled the development of a non-invasive CSF pressure measurement apparatus. We tested the system on healthy volunteers in the sitting and supine posture to mimic the range of tilt table extremes and estimated the induced CSF pressure change using measurements from the CSF hydrostatic indifferent point. We found a significant relationship between pulsation amplitude change and estimated CSF pressure change (p < 0.0001) across a range from 2.7 to 7.1 mmHg. The increase in pulse amplitude was highest in the sitting posture with greater estimated CSF pressure increase (p < 0.0001), in keeping with physiologically predicted CSF pressure response. This technique may be useful for non-invasive measurement of CSF pressure fluctuations during long-term space voyages. |
| first_indexed | 2024-03-09T07:09:09Z |
| format | Article |
| id | doaj.art-36878a0870664c1a8457788342f0af40 |
| institution | Directory Open Access Journal |
| issn | 2373-8065 |
| language | English |
| last_indexed | 2024-03-09T07:09:09Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Microgravity |
| spelling | doaj.art-36878a0870664c1a8457788342f0af402023-12-03T09:09:28ZengNature Portfolionpj Microgravity2373-80652023-03-01911510.1038/s41526-023-00269-0Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural changeW. H. Morgan0J. Khoo1A. Vukmirovic2A. Abdul-Rahman3D. An4A. Mehnert5D. Obreschkow6E. Chowdhury7D. Y. Yu8Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western AustraliaLions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western AustraliaLions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western AustraliaLions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western AustraliaLions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western AustraliaLions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western AustraliaInternational Space CentreInternational Space CentreLions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western AustraliaAbstract Spaceflight associated neuro-ocular syndrome (SANS) is common amongst astronauts on long duration space missions and is associated with signs consistent with elevated cerebrospinal fluid (CSF) pressure. Additionally, CSF pressure has been found to be elevated in a significant proportion of astronauts in whom lumbar puncture was performed after successful mission completion. We have developed a retinal photoplethysmographic technique to measure retinal vein pulsation amplitudes. This technique has enabled the development of a non-invasive CSF pressure measurement apparatus. We tested the system on healthy volunteers in the sitting and supine posture to mimic the range of tilt table extremes and estimated the induced CSF pressure change using measurements from the CSF hydrostatic indifferent point. We found a significant relationship between pulsation amplitude change and estimated CSF pressure change (p < 0.0001) across a range from 2.7 to 7.1 mmHg. The increase in pulse amplitude was highest in the sitting posture with greater estimated CSF pressure increase (p < 0.0001), in keeping with physiologically predicted CSF pressure response. This technique may be useful for non-invasive measurement of CSF pressure fluctuations during long-term space voyages.https://doi.org/10.1038/s41526-023-00269-0 |
| spellingShingle | W. H. Morgan J. Khoo A. Vukmirovic A. Abdul-Rahman D. An A. Mehnert D. Obreschkow E. Chowdhury D. Y. Yu Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change npj Microgravity |
| title | Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change |
| title_full | Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change |
| title_fullStr | Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change |
| title_full_unstemmed | Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change |
| title_short | Correlation between retinal vein pulse amplitude, estimated intracranial pressure, and postural change |
| title_sort | correlation between retinal vein pulse amplitude estimated intracranial pressure and postural change |
| url | https://doi.org/10.1038/s41526-023-00269-0 |
| work_keys_str_mv | AT whmorgan correlationbetweenretinalveinpulseamplitudeestimatedintracranialpressureandposturalchange AT jkhoo correlationbetweenretinalveinpulseamplitudeestimatedintracranialpressureandposturalchange AT avukmirovic correlationbetweenretinalveinpulseamplitudeestimatedintracranialpressureandposturalchange AT aabdulrahman correlationbetweenretinalveinpulseamplitudeestimatedintracranialpressureandposturalchange AT dan correlationbetweenretinalveinpulseamplitudeestimatedintracranialpressureandposturalchange AT amehnert correlationbetweenretinalveinpulseamplitudeestimatedintracranialpressureandposturalchange AT dobreschkow correlationbetweenretinalveinpulseamplitudeestimatedintracranialpressureandposturalchange AT echowdhury correlationbetweenretinalveinpulseamplitudeestimatedintracranialpressureandposturalchange AT dyyu correlationbetweenretinalveinpulseamplitudeestimatedintracranialpressureandposturalchange |