Attenuated Replication-Competent Herpes Simplex Virus Expressing an ECM-Modifying Transgene Hyaluronan Synthase 2 of Naked Mole Rat in Oncolytic Gene Therapy
Herpes simplex virus (HSV) has proven successful in treating human cancer. Since the approval of talimogene laherparepvec (T-VEC) in 2015, HSV has been thoroughly researched to discover novel mechanisms to combat cancer and treat other diseases. Another HSV-based drug, beremagene geperpavec (B-VEC),...
Main Authors: | Jussi Palomäki, Kiira Kalke, Julius Orpana, Liisa Lund, Fanny Frejborg, Henrik Paavilainen, Hannu Järveläinen, Veijo Hukkanen |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2023-10-01
|
Series: | Microorganisms |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-2607/11/11/2657 |
Similar Items
-
Characterisation of the intestinal epithelium and adult stem cell dynamics in the naked mole rats
by: Montazid, S
Published: (2023) -
Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age
by: J Graham Ruby, et al.
Published: (2018-01-01) -
Unusual occurrence of domestication syndrome amongst African mole-rats: Is the naked mole-rat a domestic animal?
by: Guillermo Serrano Nájera, et al.
Published: (2022-11-01) -
Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization
by: Ekaterina A. Gorshkova, et al.
Published: (2023-04-01) -
The microbiota in the intestinal and respiratory tracts of naked mole-rats revealed by high-throughput sequencing
by: Wei Cong, et al.
Published: (2018-08-01)