HMGA Proteins in Hematological Malignancies
The high mobility group AT-Hook (HMGA) proteins are a family of nonhistone chromatin remodeling proteins known as “architectural transcriptional factors”. By binding the minor groove of AT-rich DNA sequences, they interact with the transcription apparatus, altering the chromatin modeling and regulat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/6/1456 |
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| author | Angela Minervini Nicoletta Coccaro Luisa Anelli Antonella Zagaria Giorgina Specchia Francesco Albano |
| author_facet | Angela Minervini Nicoletta Coccaro Luisa Anelli Antonella Zagaria Giorgina Specchia Francesco Albano |
| author_sort | Angela Minervini |
| collection | DOAJ |
| description | The high mobility group AT-Hook (HMGA) proteins are a family of nonhistone chromatin remodeling proteins known as “architectural transcriptional factors”. By binding the minor groove of AT-rich DNA sequences, they interact with the transcription apparatus, altering the chromatin modeling and regulating gene expression by either enhancing or suppressing the binding of the more usual transcriptional activators and repressors, although they do not themselves have any transcriptional activity. Their involvement in both benign and malignant neoplasias is well-known and supported by a large volume of studies. In this review, we focus on the role of the HMGA proteins in hematological malignancies, exploring the mechanisms through which they enhance neoplastic transformation and how this knowledge could be exploited to devise tailored therapeutic strategies. |
| first_indexed | 2024-03-10T19:23:36Z |
| format | Article |
| id | doaj.art-3687d5dd47fc4be5b713f6998bef4b9d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:23:36Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-3687d5dd47fc4be5b713f6998bef4b9d2023-11-20T02:45:16ZengMDPI AGCancers2072-66942020-06-01126145610.3390/cancers12061456HMGA Proteins in Hematological MalignanciesAngela Minervini0Nicoletta Coccaro1Luisa Anelli2Antonella Zagaria3Giorgina Specchia4Francesco Albano5Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, 70124 Bari, ItalyDepartment of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, 70124 Bari, ItalyThe high mobility group AT-Hook (HMGA) proteins are a family of nonhistone chromatin remodeling proteins known as “architectural transcriptional factors”. By binding the minor groove of AT-rich DNA sequences, they interact with the transcription apparatus, altering the chromatin modeling and regulating gene expression by either enhancing or suppressing the binding of the more usual transcriptional activators and repressors, although they do not themselves have any transcriptional activity. Their involvement in both benign and malignant neoplasias is well-known and supported by a large volume of studies. In this review, we focus on the role of the HMGA proteins in hematological malignancies, exploring the mechanisms through which they enhance neoplastic transformation and how this knowledge could be exploited to devise tailored therapeutic strategies.https://www.mdpi.com/2072-6694/12/6/1456HMGA proteinshematologic malignanciesmolecular markerstargeted therapy |
| spellingShingle | Angela Minervini Nicoletta Coccaro Luisa Anelli Antonella Zagaria Giorgina Specchia Francesco Albano HMGA Proteins in Hematological Malignancies Cancers HMGA proteins hematologic malignancies molecular markers targeted therapy |
| title | HMGA Proteins in Hematological Malignancies |
| title_full | HMGA Proteins in Hematological Malignancies |
| title_fullStr | HMGA Proteins in Hematological Malignancies |
| title_full_unstemmed | HMGA Proteins in Hematological Malignancies |
| title_short | HMGA Proteins in Hematological Malignancies |
| title_sort | hmga proteins in hematological malignancies |
| topic | HMGA proteins hematologic malignancies molecular markers targeted therapy |
| url | https://www.mdpi.com/2072-6694/12/6/1456 |
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