Mechanotransduction for Muscle Protein Synthesis via Mechanically Activated Ion Channels
Cell mechanotransduction, the ability to detect physical forces and convert them into a series of biochemical events, is important for a wide range of physiological processes. Cells express an array of mechanosensors transducing physical forces into intracellular signaling cascades, including ion ch...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/2/341 |
| _version_ | 1797619820149080064 |
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| author | Timur M. Mirzoev |
| author_facet | Timur M. Mirzoev |
| author_sort | Timur M. Mirzoev |
| collection | DOAJ |
| description | Cell mechanotransduction, the ability to detect physical forces and convert them into a series of biochemical events, is important for a wide range of physiological processes. Cells express an array of mechanosensors transducing physical forces into intracellular signaling cascades, including ion channels. Ion channels that can be directly activated by mechanical cues are known as mechanically activated (MA), or stretch-activated (SA), channels. In response to repeated exposures to mechanical stimulation in the form of resistance training, enhanced protein synthesis and fiber hypertrophy are elicited in skeletal muscle, whereas a lack of mechanical stimuli due to inactivity/mechanical unloading leads to reduced muscle protein synthesis and fiber atrophy. To date, the role of MA channels in the transduction of mechanical load to intracellular signaling pathways regulating muscle protein synthesis is poorly described. This review article will discuss MA channels in striated muscle, their regulation, and putative roles in the anabolic processes in muscle cells/fibers in response to mechanical stimuli. |
| first_indexed | 2024-03-11T08:33:22Z |
| format | Article |
| id | doaj.art-36885fdbd35c40bd906142a20ef6c715 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:33:22Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-36885fdbd35c40bd906142a20ef6c7152023-11-16T21:39:55ZengMDPI AGLife2075-17292023-01-0113234110.3390/life13020341Mechanotransduction for Muscle Protein Synthesis via Mechanically Activated Ion ChannelsTimur M. Mirzoev0Myology Laboratory, Institute of Biomedical Problems RAS, 123007 Moscow, RussiaCell mechanotransduction, the ability to detect physical forces and convert them into a series of biochemical events, is important for a wide range of physiological processes. Cells express an array of mechanosensors transducing physical forces into intracellular signaling cascades, including ion channels. Ion channels that can be directly activated by mechanical cues are known as mechanically activated (MA), or stretch-activated (SA), channels. In response to repeated exposures to mechanical stimulation in the form of resistance training, enhanced protein synthesis and fiber hypertrophy are elicited in skeletal muscle, whereas a lack of mechanical stimuli due to inactivity/mechanical unloading leads to reduced muscle protein synthesis and fiber atrophy. To date, the role of MA channels in the transduction of mechanical load to intracellular signaling pathways regulating muscle protein synthesis is poorly described. This review article will discuss MA channels in striated muscle, their regulation, and putative roles in the anabolic processes in muscle cells/fibers in response to mechanical stimuli.https://www.mdpi.com/2075-1729/13/2/341mechanotransductionmechanical stimulationmechanically-activated channelsstretch-activated channelsprotein synthesisanabolic signaling |
| spellingShingle | Timur M. Mirzoev Mechanotransduction for Muscle Protein Synthesis via Mechanically Activated Ion Channels Life mechanotransduction mechanical stimulation mechanically-activated channels stretch-activated channels protein synthesis anabolic signaling |
| title | Mechanotransduction for Muscle Protein Synthesis via Mechanically Activated Ion Channels |
| title_full | Mechanotransduction for Muscle Protein Synthesis via Mechanically Activated Ion Channels |
| title_fullStr | Mechanotransduction for Muscle Protein Synthesis via Mechanically Activated Ion Channels |
| title_full_unstemmed | Mechanotransduction for Muscle Protein Synthesis via Mechanically Activated Ion Channels |
| title_short | Mechanotransduction for Muscle Protein Synthesis via Mechanically Activated Ion Channels |
| title_sort | mechanotransduction for muscle protein synthesis via mechanically activated ion channels |
| topic | mechanotransduction mechanical stimulation mechanically-activated channels stretch-activated channels protein synthesis anabolic signaling |
| url | https://www.mdpi.com/2075-1729/13/2/341 |
| work_keys_str_mv | AT timurmmirzoev mechanotransductionformuscleproteinsynthesisviamechanicallyactivatedionchannels |