Recent Progress in Biosensors for Detection of Tumor Biomarkers
Cancer is a leading cause of death worldwide, with an increasing mortality rate over the past years. The early detection of cancer contributes to early diagnosis and subsequent treatment. How to detect early cancer has become one of the hot research directions of cancer. Tumor biomarkers, biochemica...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/21/7327 |
| _version_ | 1797467091577602048 |
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| author | Mantong Li Feng Jiang Liangyi Xue Cheng Peng Zhengzheng Shi Zheng Zhang Jia Li Yupeng Pan Xinya Wang Chunqiong Feng Dongfang Qiao Zhenzhong Chen Qizhi Luo Xuncai Chen |
| author_facet | Mantong Li Feng Jiang Liangyi Xue Cheng Peng Zhengzheng Shi Zheng Zhang Jia Li Yupeng Pan Xinya Wang Chunqiong Feng Dongfang Qiao Zhenzhong Chen Qizhi Luo Xuncai Chen |
| author_sort | Mantong Li |
| collection | DOAJ |
| description | Cancer is a leading cause of death worldwide, with an increasing mortality rate over the past years. The early detection of cancer contributes to early diagnosis and subsequent treatment. How to detect early cancer has become one of the hot research directions of cancer. Tumor biomarkers, biochemical parameters for reflecting cancer occurrence and progression have caused much attention in cancer early detection. Due to high sensitivity, convenience and low cost, biosensors have been largely developed to detect tumor biomarkers. This review describes the application of various biosensors in detecting tumor markers. Firstly, several typical tumor makers, such as neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), squamous cell carcinoma antigen (SCCA), carbohydrate, antigen19-9 (CA19-9) and tumor suppressor p53 (TP53), which may be helpful for early cancer detection in the clinic, are briefly described. Then, various biosensors, mainly focusing on electrochemical biosensors, optical biosensors, photoelectrochemical biosensors, piezoelectric biosensors and aptamer sensors, are discussed. Specifically, the operation principles of biosensors, nanomaterials used in biosensors and the application of biosensors in tumor marker detection have been comprehensively reviewed and provided. Lastly, the challenges and prospects for developing effective biosensors for early cancer diagnosis are discussed. |
| first_indexed | 2024-03-09T18:48:43Z |
| format | Article |
| id | doaj.art-36897025718f4379b5f59300d45e83e9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T18:48:43Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-36897025718f4379b5f59300d45e83e92023-11-24T06:02:28ZengMDPI AGMolecules1420-30492022-10-012721732710.3390/molecules27217327Recent Progress in Biosensors for Detection of Tumor BiomarkersMantong Li0Feng Jiang1Liangyi Xue2Cheng Peng3Zhengzheng Shi4Zheng Zhang5Jia Li6Yupeng Pan7Xinya Wang8Chunqiong Feng9Dongfang Qiao10Zhenzhong Chen11Qizhi Luo12Xuncai Chen13Department of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaGuangzhou Institute of Food Inspection, Guangzhou 510080, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaGuangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaDepartment of Forensic Toxicology, School of Forensic Medicine, Southern Medical University, Guangzhou 510515, ChinaCancer is a leading cause of death worldwide, with an increasing mortality rate over the past years. The early detection of cancer contributes to early diagnosis and subsequent treatment. How to detect early cancer has become one of the hot research directions of cancer. Tumor biomarkers, biochemical parameters for reflecting cancer occurrence and progression have caused much attention in cancer early detection. Due to high sensitivity, convenience and low cost, biosensors have been largely developed to detect tumor biomarkers. This review describes the application of various biosensors in detecting tumor markers. Firstly, several typical tumor makers, such as neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), squamous cell carcinoma antigen (SCCA), carbohydrate, antigen19-9 (CA19-9) and tumor suppressor p53 (TP53), which may be helpful for early cancer detection in the clinic, are briefly described. Then, various biosensors, mainly focusing on electrochemical biosensors, optical biosensors, photoelectrochemical biosensors, piezoelectric biosensors and aptamer sensors, are discussed. Specifically, the operation principles of biosensors, nanomaterials used in biosensors and the application of biosensors in tumor marker detection have been comprehensively reviewed and provided. Lastly, the challenges and prospects for developing effective biosensors for early cancer diagnosis are discussed.https://www.mdpi.com/1420-3049/27/21/7327cancertumor biomarkerbiosensordetectionnanomaterial |
| spellingShingle | Mantong Li Feng Jiang Liangyi Xue Cheng Peng Zhengzheng Shi Zheng Zhang Jia Li Yupeng Pan Xinya Wang Chunqiong Feng Dongfang Qiao Zhenzhong Chen Qizhi Luo Xuncai Chen Recent Progress in Biosensors for Detection of Tumor Biomarkers Molecules cancer tumor biomarker biosensor detection nanomaterial |
| title | Recent Progress in Biosensors for Detection of Tumor Biomarkers |
| title_full | Recent Progress in Biosensors for Detection of Tumor Biomarkers |
| title_fullStr | Recent Progress in Biosensors for Detection of Tumor Biomarkers |
| title_full_unstemmed | Recent Progress in Biosensors for Detection of Tumor Biomarkers |
| title_short | Recent Progress in Biosensors for Detection of Tumor Biomarkers |
| title_sort | recent progress in biosensors for detection of tumor biomarkers |
| topic | cancer tumor biomarker biosensor detection nanomaterial |
| url | https://www.mdpi.com/1420-3049/27/21/7327 |
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