Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysis
BackgroundThere has existed controversy regarding the use of Ginkgo biloba (GKB) for blood metabolism among type 2 diabetes mellitus(T2DM) patients, and we tried to analyze the effects and safety of GKB on T2DM patients.MethodsWe conducted a literature search between January 2003 and December 2022 o...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1231053/full |
| _version_ | 1797360643757572096 |
|---|---|
| author | Huimin Zou Jingxian Fang Yu Han Xue Hu Jian Meng Fang Huang Hui Xu Chengfei Lu Yiwen Wang Lili Zhang Xiaohong Dong Yanmei Yu Yu Guo Qing Gu Suijun Wang |
| author_facet | Huimin Zou Jingxian Fang Yu Han Xue Hu Jian Meng Fang Huang Hui Xu Chengfei Lu Yiwen Wang Lili Zhang Xiaohong Dong Yanmei Yu Yu Guo Qing Gu Suijun Wang |
| author_sort | Huimin Zou |
| collection | DOAJ |
| description | BackgroundThere has existed controversy regarding the use of Ginkgo biloba (GKB) for blood metabolism among type 2 diabetes mellitus(T2DM) patients, and we tried to analyze the effects and safety of GKB on T2DM patients.MethodsWe conducted a literature search between January 2003 and December 2022 of seven online databases (PubMed, Scopus, Embase, Google Scholar, Web of Sciences, Cochrane Library, and China National Knowledge Infrastructure). A systematic literature review and meta-analysis were performed to compare the effects and safety of GKB among T2DM patients. Four groups of parameters were extracted and analyzed: hemorheology parameters, lipid profile, glycemic control markers, and adverse events.ResultsIn the end, 13 eligible articles with 11 indicators among 1573 patients were included. In the hemorheology parameters section, GKB showed significantly lower plasma viscosity (PV) (SMD=-0.91, 95%CI [-1.45, -0.36], P<0.01) and hematocrit (Hct) (SMD=-0.60, 95%CI [-0.97, -0.24], P<0.01) than the control group. GKB shoed higher velocity of the dorsalis pedis artery (VDPA) (SMD=0.51, 95%CI [0.26, 0.76], P<0.01) and ankle brachial index (ABI) (SMD=0.71, 95%CI [0.32, 1.10], P<0.01) than the control. In both the lipid profile and glycemic control markers sections, we did not find any difference between GKB and control groups, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), hemoglobin A1c (HbA1c), and fasting serum glucose (FSG). In addition, we saw no difference in adverse events (AE). The sensitivity analysis and funnel plot showed that the results in this research were robust and had no publication bias.ConclusionIn conclusion, GKB might safely reduce the risk of peripheral arterial or even systemic cardiovascular disease. However, GKB did not directly improve lipid and blood glucose levels in T2DM patients.Systematic review registrationhttps://inplasy.com/, identifier INPLASY202350096. |
| first_indexed | 2024-03-08T15:42:37Z |
| format | Article |
| id | doaj.art-3689fdcc8cc04d7a9bd2962ac36a69b1 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T15:42:37Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-3689fdcc8cc04d7a9bd2962ac36a69b12024-01-09T14:32:23ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.12310531231053Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysisHuimin ZouJingxian FangYu HanXue HuJian MengFang HuangHui XuChengfei LuYiwen WangLili ZhangXiaohong DongYanmei YuYu GuoQing GuSuijun WangBackgroundThere has existed controversy regarding the use of Ginkgo biloba (GKB) for blood metabolism among type 2 diabetes mellitus(T2DM) patients, and we tried to analyze the effects and safety of GKB on T2DM patients.MethodsWe conducted a literature search between January 2003 and December 2022 of seven online databases (PubMed, Scopus, Embase, Google Scholar, Web of Sciences, Cochrane Library, and China National Knowledge Infrastructure). A systematic literature review and meta-analysis were performed to compare the effects and safety of GKB among T2DM patients. Four groups of parameters were extracted and analyzed: hemorheology parameters, lipid profile, glycemic control markers, and adverse events.ResultsIn the end, 13 eligible articles with 11 indicators among 1573 patients were included. In the hemorheology parameters section, GKB showed significantly lower plasma viscosity (PV) (SMD=-0.91, 95%CI [-1.45, -0.36], P<0.01) and hematocrit (Hct) (SMD=-0.60, 95%CI [-0.97, -0.24], P<0.01) than the control group. GKB shoed higher velocity of the dorsalis pedis artery (VDPA) (SMD=0.51, 95%CI [0.26, 0.76], P<0.01) and ankle brachial index (ABI) (SMD=0.71, 95%CI [0.32, 1.10], P<0.01) than the control. In both the lipid profile and glycemic control markers sections, we did not find any difference between GKB and control groups, including total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), hemoglobin A1c (HbA1c), and fasting serum glucose (FSG). In addition, we saw no difference in adverse events (AE). The sensitivity analysis and funnel plot showed that the results in this research were robust and had no publication bias.ConclusionIn conclusion, GKB might safely reduce the risk of peripheral arterial or even systemic cardiovascular disease. However, GKB did not directly improve lipid and blood glucose levels in T2DM patients.Systematic review registrationhttps://inplasy.com/, identifier INPLASY202350096.https://www.frontiersin.org/articles/10.3389/fendo.2023.1231053/fullGinkgo bilobaGKBtype 2 diabetes mellitusT2DMmeta-analysis |
| spellingShingle | Huimin Zou Jingxian Fang Yu Han Xue Hu Jian Meng Fang Huang Hui Xu Chengfei Lu Yiwen Wang Lili Zhang Xiaohong Dong Yanmei Yu Yu Guo Qing Gu Suijun Wang Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysis Frontiers in Endocrinology Ginkgo biloba GKB type 2 diabetes mellitus T2DM meta-analysis |
| title | Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysis |
| title_full | Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysis |
| title_fullStr | Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysis |
| title_full_unstemmed | Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysis |
| title_short | Effects and safety of Ginkgo biloba on blood metabolism in type 2 diabetes mellitus: a systematic review and meta-analysis |
| title_sort | effects and safety of ginkgo biloba on blood metabolism in type 2 diabetes mellitus a systematic review and meta analysis |
| topic | Ginkgo biloba GKB type 2 diabetes mellitus T2DM meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1231053/full |
| work_keys_str_mv | AT huiminzou effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT jingxianfang effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT yuhan effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT xuehu effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT jianmeng effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT fanghuang effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT huixu effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT chengfeilu effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT yiwenwang effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT lilizhang effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT xiaohongdong effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT yanmeiyu effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT yuguo effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT qinggu effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis AT suijunwang effectsandsafetyofginkgobilobaonbloodmetabolismintype2diabetesmellitusasystematicreviewandmetaanalysis |