Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review
Vitamin D has known immunomodulatory activity and multiple indications exist supporting its potential use against SARS-CoV-2 infection in the setting of the current pandemic. The purpose of this systematic review is to examine the efficacy of vitamin D administered to adult patients following COVID-...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/3/419 |
| _version_ | 1797446338009366528 |
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| author | Angelina Bania Konstantinos Pitsikakis Georgios Mavrovounis Maria Mermiri Eleftherios T. Beltsios Antonis Adamou Vasiliki Konstantaki Demosthenes Makris Vasiliki Tsolaki Konstantinos Gourgoulianis Ioannis Pantazopoulos |
| author_facet | Angelina Bania Konstantinos Pitsikakis Georgios Mavrovounis Maria Mermiri Eleftherios T. Beltsios Antonis Adamou Vasiliki Konstantaki Demosthenes Makris Vasiliki Tsolaki Konstantinos Gourgoulianis Ioannis Pantazopoulos |
| author_sort | Angelina Bania |
| collection | DOAJ |
| description | Vitamin D has known immunomodulatory activity and multiple indications exist supporting its potential use against SARS-CoV-2 infection in the setting of the current pandemic. The purpose of this systematic review is to examine the efficacy of vitamin D administered to adult patients following COVID-19 diagnosis in terms of length of hospital stay, intubation, ICU admission and mortality rates. Therefore, PubMed and Scopus databases were searched for original articles referring to the aforementioned parameters. Of the 1376 identified studies, eleven were finally included. Vitamin D supplements, and especially calcifediol, were shown to be useful in significantly reducing ICU admissions and/or mortality in four of the studies, but not in diminishing the duration of hospitalization of COVID-19 patients. Due to the large variation in vitamin D supplementation schemes no absolute conclusions can be drawn until larger randomized controlled trials are completed. However, calcifediol administered to COVID-19 patients upon diagnosis represents by far the most promising agent and should be the focus of upcoming research efforts. |
| first_indexed | 2024-03-09T13:39:10Z |
| format | Article |
| id | doaj.art-368ead7d98b74b0fb078ae58527b6fc4 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T13:39:10Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-368ead7d98b74b0fb078ae58527b6fc42023-11-30T21:08:12ZengMDPI AGJournal of Personalized Medicine2075-44262022-03-0112341910.3390/jpm12030419Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic ReviewAngelina Bania0Konstantinos Pitsikakis1Georgios Mavrovounis2Maria Mermiri3Eleftherios T. Beltsios4Antonis Adamou5Vasiliki Konstantaki6Demosthenes Makris7Vasiliki Tsolaki8Konstantinos Gourgoulianis9Ioannis Pantazopoulos10Faculty of Medicine, School of Health Sciences, University of Patras, 26504 Rion, GreeceSchool of Medicine, University of Crete, 71003 Heraklion, GreeceDepartment of Emergency Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, GreeceDepartment of Anesthesiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, GreeceDepartment of Emergency Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, GreeceDepartment of Radiology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, GreeceDepartment of Anesthesiology, General Hospital of Limassol, Limassol 4131, CyprusCritical Care Department, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, GreeceCritical Care Department, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, GreeceDepartment of Respiratory Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, GreeceDepartment of Emergency Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41110 Larissa, GreeceVitamin D has known immunomodulatory activity and multiple indications exist supporting its potential use against SARS-CoV-2 infection in the setting of the current pandemic. The purpose of this systematic review is to examine the efficacy of vitamin D administered to adult patients following COVID-19 diagnosis in terms of length of hospital stay, intubation, ICU admission and mortality rates. Therefore, PubMed and Scopus databases were searched for original articles referring to the aforementioned parameters. Of the 1376 identified studies, eleven were finally included. Vitamin D supplements, and especially calcifediol, were shown to be useful in significantly reducing ICU admissions and/or mortality in four of the studies, but not in diminishing the duration of hospitalization of COVID-19 patients. Due to the large variation in vitamin D supplementation schemes no absolute conclusions can be drawn until larger randomized controlled trials are completed. However, calcifediol administered to COVID-19 patients upon diagnosis represents by far the most promising agent and should be the focus of upcoming research efforts.https://www.mdpi.com/2075-4426/12/3/419COVID-19vitamin DhospitalizationICU admissionintubationmortality |
| spellingShingle | Angelina Bania Konstantinos Pitsikakis Georgios Mavrovounis Maria Mermiri Eleftherios T. Beltsios Antonis Adamou Vasiliki Konstantaki Demosthenes Makris Vasiliki Tsolaki Konstantinos Gourgoulianis Ioannis Pantazopoulos Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review Journal of Personalized Medicine COVID-19 vitamin D hospitalization ICU admission intubation mortality |
| title | Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review |
| title_full | Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review |
| title_fullStr | Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review |
| title_full_unstemmed | Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review |
| title_short | Therapeutic Vitamin D Supplementation Following COVID-19 Diagnosis: Where Do We Stand?—A Systematic Review |
| title_sort | therapeutic vitamin d supplementation following covid 19 diagnosis where do we stand a systematic review |
| topic | COVID-19 vitamin D hospitalization ICU admission intubation mortality |
| url | https://www.mdpi.com/2075-4426/12/3/419 |
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