Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2013-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200109 |
| _version_ | 1811229979328905216 |
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| author | C. Teixeira R. Gomes |
| author_facet | C. Teixeira R. Gomes |
| author_sort | C. Teixeira |
| collection | DOAJ |
| description | Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to human disease by looking into two important parasitic diseases: malaria and leishmaniasis. |
| first_indexed | 2024-04-12T10:22:29Z |
| format | Article |
| id | doaj.art-368eb640951d4bfa9a5554080bd5430a |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-12T10:22:29Z |
| publishDate | 2013-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-368eb640951d4bfa9a5554080bd5430a2022-12-22T03:37:04ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2013-01-01462109116C. TeixeiraR. GomesAnimal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to human disease by looking into two important parasitic diseases: malaria and leishmaniasis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200109Human vaccinesAnimal modelsMalariaLeishmaniasis |
| spellingShingle | C. Teixeira R. Gomes Brazilian Journal of Medical and Biological Research Human vaccines Animal models Malaria Leishmaniasis |
| topic | Human vaccines Animal models Malaria Leishmaniasis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200109 |