Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics
Reactive Oxygen Species or “ROS” encompass several molecules derived from oxygen that can oxidize other molecules and subsequently transition rapidly between species. The key roles of ROS in biological processes are cell signaling, biosynthetic processes, and host defense. In cancer cells, increased...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/9/3100 |
| _version_ | 1797569402830323712 |
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| author | Alia Ghoneum Ammar Yasser Abdulfattah Bailey Olivia Warren Junjun Shu Neveen Said |
| author_facet | Alia Ghoneum Ammar Yasser Abdulfattah Bailey Olivia Warren Junjun Shu Neveen Said |
| author_sort | Alia Ghoneum |
| collection | DOAJ |
| description | Reactive Oxygen Species or “ROS” encompass several molecules derived from oxygen that can oxidize other molecules and subsequently transition rapidly between species. The key roles of ROS in biological processes are cell signaling, biosynthetic processes, and host defense. In cancer cells, increased ROS production and oxidative stress are instigated by carcinogens, oncogenic mutations, and importantly, metabolic reprograming of the rapidly proliferating cancer cells. Increased ROS production activates myriad downstream survival pathways that further cancer progression and metastasis. In this review, we highlight the relation between ROS, the metabolic programing of cancer, and stromal and immune cells with emphasis on and the transcription machinery involved in redox homeostasis, metabolic programing and malignant phenotype. We also shed light on the therapeutic targeting of metabolic pathways generating ROS as we investigate: Orlistat, Biguandes, AICAR, 2 Deoxyglucose, CPI-613, and Etomoxir. |
| first_indexed | 2024-03-10T20:11:13Z |
| format | Article |
| id | doaj.art-36944ced773d47969a80cf52d6580a8a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:11:13Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-36944ced773d47969a80cf52d6580a8a2023-11-19T22:55:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01219310010.3390/ijms21093100Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted TherapeuticsAlia Ghoneum0Ammar Yasser Abdulfattah1Bailey Olivia Warren2Junjun Shu3Neveen Said4Departments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USADepartments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USADepartments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USADepartments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USADepartments of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USAReactive Oxygen Species or “ROS” encompass several molecules derived from oxygen that can oxidize other molecules and subsequently transition rapidly between species. The key roles of ROS in biological processes are cell signaling, biosynthetic processes, and host defense. In cancer cells, increased ROS production and oxidative stress are instigated by carcinogens, oncogenic mutations, and importantly, metabolic reprograming of the rapidly proliferating cancer cells. Increased ROS production activates myriad downstream survival pathways that further cancer progression and metastasis. In this review, we highlight the relation between ROS, the metabolic programing of cancer, and stromal and immune cells with emphasis on and the transcription machinery involved in redox homeostasis, metabolic programing and malignant phenotype. We also shed light on the therapeutic targeting of metabolic pathways generating ROS as we investigate: Orlistat, Biguandes, AICAR, 2 Deoxyglucose, CPI-613, and Etomoxir.https://www.mdpi.com/1422-0067/21/9/3100redox systemsROSoxidative stressmetabolismHIF-1αPGC-1α |
| spellingShingle | Alia Ghoneum Ammar Yasser Abdulfattah Bailey Olivia Warren Junjun Shu Neveen Said Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics International Journal of Molecular Sciences redox systems ROS oxidative stress metabolism HIF-1α PGC-1α |
| title | Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics |
| title_full | Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics |
| title_fullStr | Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics |
| title_full_unstemmed | Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics |
| title_short | Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics |
| title_sort | redox homeostasis and metabolism in cancer a complex mechanism and potential targeted therapeutics |
| topic | redox systems ROS oxidative stress metabolism HIF-1α PGC-1α |
| url | https://www.mdpi.com/1422-0067/21/9/3100 |
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