Genetic variants for personalised management of very low carbohydrate ketogenic diets
The ketogenic diet (KD) is a low-carbohydrate, high-fat, adequate-protein diet proven to be effective for the reversal of obesity, metabolic syndrome and type 2 diabetes, and holding therapeutic potential for the prevention and treatment of other chronic diseases. Genetic and dynamic markers of KD r...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
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| Series: | BMJ Nutrition, Prevention & Health |
| Online Access: | https://nutrition.bmj.com/content/early/2020/12/10/bmjnph-2020-000167.full |
| _version_ | 1818566135794106368 |
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| author | Lucia Aronica Jeff Volek Angela Poff Dominic P D'agostino |
| author_facet | Lucia Aronica Jeff Volek Angela Poff Dominic P D'agostino |
| author_sort | Lucia Aronica |
| collection | DOAJ |
| description | The ketogenic diet (KD) is a low-carbohydrate, high-fat, adequate-protein diet proven to be effective for the reversal of obesity, metabolic syndrome and type 2 diabetes, and holding therapeutic potential for the prevention and treatment of other chronic diseases. Genetic and dynamic markers of KD response may help to identify individuals most likely to benefit from KD and point to individuals at higher risk for adverse health outcomes. Here, we provide a clinician-friendly review of state-of-the-art research on biomarkers of KD response for a variety of outcomes including weight loss, body composition and cognitive performance drawing data from both intervention trials and case reports of rare inborn errors of metabolism. We also present a selection of the most promising candidate genes to evaluate in future studies and discuss key aspects of study design and variant interpretation that may help accelerate the implementation of these biomarkers in clinical practice. |
| first_indexed | 2024-12-14T01:49:52Z |
| format | Article |
| id | doaj.art-369499d7ac8940e6a5ea5a812fe4da4c |
| institution | Directory Open Access Journal |
| issn | 2516-5542 |
| language | English |
| last_indexed | 2024-12-14T01:49:52Z |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Nutrition, Prevention & Health |
| spelling | doaj.art-369499d7ac8940e6a5ea5a812fe4da4c2022-12-21T23:21:25ZengBMJ Publishing GroupBMJ Nutrition, Prevention & Health2516-554210.1136/bmjnph-2020-000167Genetic variants for personalised management of very low carbohydrate ketogenic dietsLucia Aronica0Jeff Volek1Angela Poff2Dominic P D'agostino3Nutrition Science, Metagenics Inc, Gig Harbor, Washington, USAHuman Sciences, The Ohio State University, Columbus, Ohio, USAMedicine Molecular Pharmacology & Physiology, University of South Florida, Tampa, Florida, USAMedicine Molecular Pharmacology & Physiology, University of South Florida, Tampa, Florida, USAThe ketogenic diet (KD) is a low-carbohydrate, high-fat, adequate-protein diet proven to be effective for the reversal of obesity, metabolic syndrome and type 2 diabetes, and holding therapeutic potential for the prevention and treatment of other chronic diseases. Genetic and dynamic markers of KD response may help to identify individuals most likely to benefit from KD and point to individuals at higher risk for adverse health outcomes. Here, we provide a clinician-friendly review of state-of-the-art research on biomarkers of KD response for a variety of outcomes including weight loss, body composition and cognitive performance drawing data from both intervention trials and case reports of rare inborn errors of metabolism. We also present a selection of the most promising candidate genes to evaluate in future studies and discuss key aspects of study design and variant interpretation that may help accelerate the implementation of these biomarkers in clinical practice.https://nutrition.bmj.com/content/early/2020/12/10/bmjnph-2020-000167.full |
| spellingShingle | Lucia Aronica Jeff Volek Angela Poff Dominic P D'agostino Genetic variants for personalised management of very low carbohydrate ketogenic diets BMJ Nutrition, Prevention & Health |
| title | Genetic variants for personalised management of very low carbohydrate ketogenic diets |
| title_full | Genetic variants for personalised management of very low carbohydrate ketogenic diets |
| title_fullStr | Genetic variants for personalised management of very low carbohydrate ketogenic diets |
| title_full_unstemmed | Genetic variants for personalised management of very low carbohydrate ketogenic diets |
| title_short | Genetic variants for personalised management of very low carbohydrate ketogenic diets |
| title_sort | genetic variants for personalised management of very low carbohydrate ketogenic diets |
| url | https://nutrition.bmj.com/content/early/2020/12/10/bmjnph-2020-000167.full |
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