Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?
The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in a wide range of tumour types. How do...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-12-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/7/12/2938 |
| _version_ | 1818306835634978816 |
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| author | Samantha Turnbull Emma J. West Karen J. Scott Elizabeth Appleton Alan Melcher Christy Ralph |
| author_facet | Samantha Turnbull Emma J. West Karen J. Scott Elizabeth Appleton Alan Melcher Christy Ralph |
| author_sort | Samantha Turnbull |
| collection | DOAJ |
| description | The last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in a wide range of tumour types. How do we move forward into the clinical setting and translate something which has such potential into meaningful clinical outcomes? Here, we review how the field of oncolytic virotherapy has developed thus far and what the future may hold. |
| first_indexed | 2024-12-13T06:48:48Z |
| format | Article |
| id | doaj.art-3696656bf094438d87d6887fd4f64d83 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-13T06:48:48Z |
| publishDate | 2015-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-3696656bf094438d87d6887fd4f64d832022-12-21T23:56:12ZengMDPI AGViruses1999-49152015-12-017126291631210.3390/v7122938v7122938Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going?Samantha Turnbull0Emma J. West1Karen J. Scott2Elizabeth Appleton3Alan Melcher4Christy Ralph5Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UKLeeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UKLeeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UKLeeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UKLeeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UKLeeds Institute of Cancer and Pathology, University of Leeds, Leeds LS2 9JT, UKThe last few years have seen an increased interest in immunotherapy in the treatment of malignant disease. In particular, there has been significant enthusiasm for oncolytic virotherapy, with a large amount of pre-clinical data showing promise in animal models in a wide range of tumour types. How do we move forward into the clinical setting and translate something which has such potential into meaningful clinical outcomes? Here, we review how the field of oncolytic virotherapy has developed thus far and what the future may hold.http://www.mdpi.com/1999-4915/7/12/2938oncolytic virusimmunotherapyreovirusvacciniaHSVclinical trials |
| spellingShingle | Samantha Turnbull Emma J. West Karen J. Scott Elizabeth Appleton Alan Melcher Christy Ralph Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? Viruses oncolytic virus immunotherapy reovirus vaccinia HSV clinical trials |
| title | Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? |
| title_full | Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? |
| title_fullStr | Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? |
| title_full_unstemmed | Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? |
| title_short | Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? |
| title_sort | evidence for oncolytic virotherapy where have we got to and where are we going |
| topic | oncolytic virus immunotherapy reovirus vaccinia HSV clinical trials |
| url | http://www.mdpi.com/1999-4915/7/12/2938 |
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