Novel Interactions of Myristic Acid and <i>FADS3</i> Variants Predict Atopic Dermatitis among Indonesian Infants
Fatty acids exert a range of different biological activities that could be relevant in the development of atopic dermatitis (AD). This study investigated the association of glycerophospholipid fatty acids (GPL-FA) with AD, and their interactions with single nucleotide polymorphisms (SNP) of the <...
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/21/4676 |
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| author | Conny Tanjung Carla P. Harris Hans Demmelmair Sarah Dwitya Zakiudin Munasir Herawati Sudoyo Marie Standl Damayanti Rusli Sjarif Berthold Koletzko |
| author_facet | Conny Tanjung Carla P. Harris Hans Demmelmair Sarah Dwitya Zakiudin Munasir Herawati Sudoyo Marie Standl Damayanti Rusli Sjarif Berthold Koletzko |
| author_sort | Conny Tanjung |
| collection | DOAJ |
| description | Fatty acids exert a range of different biological activities that could be relevant in the development of atopic dermatitis (AD). This study investigated the association of glycerophospholipid fatty acids (GPL-FA) with AD, and their interactions with single nucleotide polymorphisms (SNP) of the <i>FADS1-3</i> gene cluster. Among 390 infants of the Indonesian ISADI study, GPL-FA were measured in umbilical plasma (P-0y) and in buccal cells at birth (B-0y), and again in buccal cells at AD onset or one year (B-1y). Prospective and cross-sectional associations with AD were assessed by logistic regression. Interactions of GPL-FA with 14 SNP were tested assuming an additive model. AD was diagnosed in 15.4% of participants. In B-1y, C18:2n-6 was inversely associated with AD; and positive associations were observed for C18:1n-9, C20:4n-6, C22:6n-3 and C20:4n-6/C18:2n-6. There were no prospective associations with AD, however, a significant interaction between the SNP rs174449 and B-0y C14:0 (myristic acid) was observed. This study indicates that Indonesian infants with AD have increased rates of endogenous long-chain polyunsaturated fatty acid production, as well as higher C18:1n-9 levels. GPL-FA measured at birth do not predict later AD incidence; however, genotype interactions reveal novel effects of myristic acid, which are modified by a <i>FADS3</i> variant. |
| first_indexed | 2024-03-09T18:45:51Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T18:45:51Z |
| publishDate | 2022-11-01 |
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| series | Nutrients |
| spelling | doaj.art-369a4d78ced848ac936b3fb53ac0cc622023-11-24T06:15:27ZengMDPI AGNutrients2072-66432022-11-011421467610.3390/nu14214676Novel Interactions of Myristic Acid and <i>FADS3</i> Variants Predict Atopic Dermatitis among Indonesian InfantsConny Tanjung0Carla P. Harris1Hans Demmelmair2Sarah Dwitya3Zakiudin Munasir4Herawati Sudoyo5Marie Standl6Damayanti Rusli Sjarif7Berthold Koletzko8Graduate School, Hasanuddin University, Makassar 90245, IndonesiaDepartment of Pediatrics, Dr. von Hauner Children’s Hospital, LMU University Hospitals, LMU-Ludwig Maximilians Universität Munich, 80337 Munich, GermanyDepartment of Pediatrics, Dr. von Hauner Children’s Hospital, LMU University Hospitals, LMU-Ludwig Maximilians Universität Munich, 80337 Munich, GermanyKemayoran Public District Hospital, Central Jakarta, Jakarta 10650, IndonesiaDepartments of Pediatrics, Faculty of Medicine, Universitas Indonesia, Dr. Ciptomangunkusumo National Referral Hospital, Jakarta 10430, IndonesiaEijkman Institute for Molecular Biology, Jakarta 10430, IndonesiaHelmholtz Centre Munich-German Research Center for Environmental Health, Institute of Epidemiology, 85764 Neuherberg, GermanyIMERI Faculty of Medicine, Human Genetic Research Cluster, Universitas Indonesia, Jakarta 10430, IndonesiaDepartment of Pediatrics, Dr. von Hauner Children’s Hospital, LMU University Hospitals, LMU-Ludwig Maximilians Universität Munich, 80337 Munich, GermanyFatty acids exert a range of different biological activities that could be relevant in the development of atopic dermatitis (AD). This study investigated the association of glycerophospholipid fatty acids (GPL-FA) with AD, and their interactions with single nucleotide polymorphisms (SNP) of the <i>FADS1-3</i> gene cluster. Among 390 infants of the Indonesian ISADI study, GPL-FA were measured in umbilical plasma (P-0y) and in buccal cells at birth (B-0y), and again in buccal cells at AD onset or one year (B-1y). Prospective and cross-sectional associations with AD were assessed by logistic regression. Interactions of GPL-FA with 14 SNP were tested assuming an additive model. AD was diagnosed in 15.4% of participants. In B-1y, C18:2n-6 was inversely associated with AD; and positive associations were observed for C18:1n-9, C20:4n-6, C22:6n-3 and C20:4n-6/C18:2n-6. There were no prospective associations with AD, however, a significant interaction between the SNP rs174449 and B-0y C14:0 (myristic acid) was observed. This study indicates that Indonesian infants with AD have increased rates of endogenous long-chain polyunsaturated fatty acid production, as well as higher C18:1n-9 levels. GPL-FA measured at birth do not predict later AD incidence; however, genotype interactions reveal novel effects of myristic acid, which are modified by a <i>FADS3</i> variant.https://www.mdpi.com/2072-6643/14/21/4676atopic dermatitisfatty acids<i>FADS</i> gene variantsmetabolisminfants |
| spellingShingle | Conny Tanjung Carla P. Harris Hans Demmelmair Sarah Dwitya Zakiudin Munasir Herawati Sudoyo Marie Standl Damayanti Rusli Sjarif Berthold Koletzko Novel Interactions of Myristic Acid and <i>FADS3</i> Variants Predict Atopic Dermatitis among Indonesian Infants Nutrients atopic dermatitis fatty acids <i>FADS</i> gene variants metabolism infants |
| title | Novel Interactions of Myristic Acid and <i>FADS3</i> Variants Predict Atopic Dermatitis among Indonesian Infants |
| title_full | Novel Interactions of Myristic Acid and <i>FADS3</i> Variants Predict Atopic Dermatitis among Indonesian Infants |
| title_fullStr | Novel Interactions of Myristic Acid and <i>FADS3</i> Variants Predict Atopic Dermatitis among Indonesian Infants |
| title_full_unstemmed | Novel Interactions of Myristic Acid and <i>FADS3</i> Variants Predict Atopic Dermatitis among Indonesian Infants |
| title_short | Novel Interactions of Myristic Acid and <i>FADS3</i> Variants Predict Atopic Dermatitis among Indonesian Infants |
| title_sort | novel interactions of myristic acid and i fads3 i variants predict atopic dermatitis among indonesian infants |
| topic | atopic dermatitis fatty acids <i>FADS</i> gene variants metabolism infants |
| url | https://www.mdpi.com/2072-6643/14/21/4676 |
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